Selectivity data for probe ERKi and control ERKi-NC


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ERKi


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A -1.87
5-HT1B HTR1B 4.23
5-HT1D HTR1D 1.59
5-HT1E HTR1E -10.70
5-HT2A HTR2A 7.44
5-HT2B HTR2B 13.10
5-HT2C HTR2C 26.33
5-HT3 HTR3A 4.36
5-HT5A HTR5A 1.39
5-HT6 HTR6 8.67
5-HT7A HTR7 21.75
D1 DRD1 -3.50
D2 DRD2 -13.07
D3 DRD3 -2.24
D4 DRD4 -1.00
D5 DRD5 21.10
SERT SLC6A4 2.86
NET SLC6A2 -9.99
DAT SLC6A3 46.47
MOR OPRM1 6.82
DOR OPRD1 -18.71
KOR OPRK1 10.30
GABAA -19.87
H1 HRH1 -7.28
H2 HRH2 11.82
H3 HRH3 7.46
H4 HRH4 35.29
Alpha1A ADRA1A 16.07
Alpha1B ADRA1B -2.72
Alpha2A ADRA2A 9.20
Alpha2B ADRA2B -1.50
Alpha2C ADRA2C -8.07
Beta1 ADRB1 6.72
Beta2 ADRB2 1.36
M1 CHRM1 -1.16
M2 CHRM2 -3.22
M3 CHRM3 -5.17
M4 CHRM4 -0.57
M5 CHRM5 35.80
Beta3 ADRB3 24.14
GABAA/BZP 46.21
GABA/PBR 8.66
Alpha1D ADRA1D -15.13
Sigma 2 TMEM97 -10.12
Sigma 1 SIGMAR1 -27.53

ERKi-NC


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A 20.04
5-HT1B HTR1B -11.60
5-HT1D HTR1D 39.91
5-HT1E HTR1E -8.44
5-HT2A HTR2A 7.64
5-HT2B HTR2B 90.90 538.00 6.27
5-HT2C HTR2C 13.56
5-HT3 HTR3A -0.28
5-HT5A HTR5A 9.46
5-HT6 HTR6 -12.88
5-HT7A HTR7 33.36
D1 DRD1 4.28
D2 DRD2 17.74
D3 DRD3 27.93
D4 DRD4 16.64
D5 DRD5 7.56
SERT SLC6A4 -0.79
NET SLC6A2 25.45
DAT SLC6A3 4.79
MOR OPRM1 -6.59
DOR OPRD1 2.71
KOR OPRK1 22.85
GABAA 25.50
H1 HRH1 4.18
H2 HRH2 3.05
H3 HRH3 21.09
H4 HRH4 41.87
Alpha1A ADRA1A -8.50
Alpha1B ADRA1B 1.42
Alpha2A ADRA2A 16.84
Alpha2B ADRA2B -0.47
Alpha2C ADRA2C 11.46
Beta1 ADRB1 28.16
Beta2 ADRB2 -12.79
M1 CHRM1 -12.24
M2 CHRM2 14.15
M3 CHRM3 -1.84
M4 CHRM4 18.71
M5 CHRM5 7.22
Beta3 ADRB3 13.62
GABAA/BZP 20.23
GABA/PBR -1.65
Alpha1D ADRA1D -7.90
Sigma 2 TMEM97 20.78
Sigma 1 SIGMAR1 12.80

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
View assay details

Jump to control KinomeScan data

ERKi


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 52.5 100
ABL1 ABL1-phosphorylated 87.0 100
ABL2 ABL2 83.9 100
ACVR1 ACVR1 98.3 100
ACVR1B ACVR1B 100.0 100
ACVR2A ACVR2A 74.7 100
ACVR2B ACVR2B 87.6 100
ACVRL1 ACVRL1 90.9 100
COQ8A ADCK3 89.6 100
COQ8B ADCK4 86.7 100
AKT1 AKT1 100.0 100
AKT2 AKT2 100.0 100
AKT3 AKT3 73.3 100
ALK ALK(L1196M) 96.9 100
PRKAA1 AMPK-alpha1 91.0 100
PRKAA2 AMPK-alpha2 59.6 100
ANKK1 ANKK1 78.2 100
NUAK1 ARK5 94.9 100
MAP3K5 ASK1 100.0 100
MAP3K6 ASK2 99.3 100
AURKA AURKA 82.0 100
AURKB AURKB 100.0 100
AURKC AURKC 100.0 100
AXL AXL 77.9 100
BMP2K BIKE 91.9 100
BLK BLK 100.0 100
BMPR1A BMPR1A 100.0 100
BMPR1B BMPR1B 69.4 100
BMPR2 BMPR2 70.3 100
BMX BMX 94.3 100
BRAF BRAF(V600E) 100.0 100
PTK6 BRK 86.6 100
BRSK1 BRSK1 88.4 100
BRSK2 BRSK2 89.3 100
BTK BTK 100.0 100
BUB1 BUB1 96.0 100
CAMK1 CAMK1 67.1 100
PNCK CAMK1B 91.2 100
CAMK1D CAMK1D 83.3 100
CAMK1G CAMK1G 70.6 100
CAMK2A CAMK2A 73.5 100
CAMK2B CAMK2B 75.2 100
CAMK2D CAMK2D 77.7 100
CAMK2G CAMK2G 84.6 100
CAMK4 CAMK4 100.0 100
CAMKK1 CAMKK1 87.5 100
CAMKK2 CAMKK2 75.2 100
CASK CASK 89.7 100
CDK11B CDC2L1 97.4 100
CDK11A CDC2L2 100.0 100
CDK13 CDC2L5 45.7 100
CDK19 CDK11 97.2 100
CDK2 CDK2 75.7 100
CDK3 CDK3 86.1 100
CDK4 CDK4-cyclinD3 83.1 100
CDK5 CDK5 100.0 100
CDK7 CDK7 73.6 100 = 230.0
CDK8 CDK8 76.1 100
CDK9 CDK9 95.4 100
CDKL1 CDKL1 81.1 100
CDKL2 CDKL2 81.0 100
CDKL3 CDKL3 95.6 100
CDKL5 CDKL5 88.3 100
CHEK1 CHEK1 97.1 100
CHEK2 CHEK2 100.0 100
CIT CIT 100.0 100
CLK1 CLK1 72.6 100
CLK2 CLK2 68.5 100
CLK3 CLK3 82.2 100
CLK4 CLK4 66.6 100 = 230.0
CSF1R CSF1R-autoinhibited 87.3 100
CSK CSK 77.1 100
CSNK1A1 CSNK1A1 84.6 100
CSNK1A1L CSNK1A1L 79.8 100
CSNK1D CSNK1D 84.7 100
CSNK1E CSNK1E 95.1 100
CSNK1G1 CSNK1G1 83.0 100
CSNK1G2 CSNK1G2 100.0 100
CSNK1G3 CSNK1G3 87.9 100
CSNK2A1 CSNK2A1 94.0 100
CSNK2A2 CSNK2A2 76.0 100
MATK CTK 72.1 100
DAPK1 DAPK1 90.5 100
DAPK2 DAPK2 66.3 100
DAPK3 DAPK3 77.4 100
DCLK1 DCAMKL1 90.3 100
DCLK2 DCAMKL2 97.7 100
DCLK3 DCAMKL3 97.1 100
DDR1 DDR1 100.0 100
DDR2 DDR2 98.5 100
MAP3K12 DLK 97.4 100
DMPK DMPK 80.5 100
CDC42BPG DMPK2 98.2 100
STK17A DRAK1 88.0 100
STK17B DRAK2 95.8 100
DYRK1A DYRK1A 49.0 100
DYRK1B DYRK1B 95.9 100
DYRK2 DYRK2 59.3 100
EGFR EGFR(T790M) 82.1 100
EIF2AK1 EIF2AK1 92.8 100
EPHA1 EPHA1 100.0 100
EPHA2 EPHA2 100.0 100
EPHA3 EPHA3 79.4 100
EPHA4 EPHA4 100.0 100
EPHA5 EPHA5 87.9 100
EPHA6 EPHA6 100.0 100
EPHA7 EPHA7 91.1 100
EPHA8 EPHA8 89.8 100
EPHB1 EPHB1 91.1 100
EPHB2 EPHB2 83.3 100
EPHB3 EPHB3 94.8 100
EPHB4 EPHB4 87.6 100
EPHB6 EPHB6 75.5 100
ERBB2 ERBB2 100.0 100
ERBB3 ERBB3 99.0 100
ERBB4 ERBB4 97.6 100
MAPK3 ERK1 0.2 100 = 1.5
MAPK1 ERK2 1.0 100 = 4.8
MAPK6 ERK3 95.2 100
MAPK4 ERK4 98.3 100
MAPK7 ERK5 85.5 100
MAPK15 ERK8 37.1 100 = 4.8 = 30.0
ERN1 ERN1 61.6 100
PTK2 FAK 85.7 100
FER FER 100.0 100
FES FES 100.0 100
FGFR1 FGFR1 94.1 100
FGFR2 FGFR2 100.0 100
FGFR3 FGFR3(G697C) 100.0 100
FGFR4 FGFR4 100.0 100
FGR FGR 100.0 100
FLT1 FLT1 100.0 100
FLT3 FLT3-autoinhibited 91.6 100
FLT4 FLT4 100.0 100
FRK FRK 82.2 100
FYN FYN 95.2 100
GAK GAK 100.0 100
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 100
GRK1 GRK1 78.3 100
GRK2 GRK2 79.5 100 = 110.0
GRK3 GRK3 60.8 100 = 140.0
GRK4 GRK4 100.0 100
GRK7 GRK7 81.4 100
GSK3A GSK3A 88.0 100
GSK3B GSK3B 100.0 100
HASPIN HASPIN 53.7 100 = 130.0
HCK HCK 94.6 100
HIPK1 HIPK1 83.1 100
HIPK2 HIPK2 85.6 100
HIPK3 HIPK3 96.2 100
HIPK4 HIPK4 77.5 100
MAP4K1 HPK1 96.9 100
HUNK HUNK 100.0 100
CILK1 ICK 80.9 100
IGF1R IGF1R 97.9 100
CHUK IKK-alpha 100.0 100
IKBKB IKK-beta 100.0 100
IKBKE IKK-epsilon 66.7 100
INSR INSR 74.7 100
INSRR INSRR 82.9 100
IRAK1 IRAK1 54.8 100
IRAK3 IRAK3 80.0 100
IRAK4 IRAK4 76.1 100
ITK ITK 83.2 100
JAK1 JAK1(JH2domain-pseudokinase) 77.0 100
JAK2 JAK2(JH1domain-catalytic) 93.7 100
JAK3 JAK3(JH1domain-catalytic) 64.5 100
MAPK8 JNK1 93.7 100
MAPK9 JNK2 79.5 100
MAPK10 JNK3 68.1 100 = 4.8
KIT KIT-autoinhibited 89.5 100
LATS1 LATS1 59.3 100
LATS2 LATS2 29.0 100 = 55.0
LCK LCK 94.8 100
LIMK1 LIMK1 94.1 100
LIMK2 LIMK2 100.0 100
STK11 LKB1 91.2 100
STK10 LOK 84.8 100
LRRK2 LRRK2(G2019S) 82.7 100
LTK LTK 98.5 100
LYN LYN 84.5 100
MAP3K13 LZK 100.0 100
MAK MAK 97.9 100
MAP3K1 MAP3K1 100.0 100
MAP3K15 MAP3K15 100.0 100
MAP3K2 MAP3K2 87.3 100
MAP3K3 MAP3K3 82.1 100
MAP3K4 MAP3K4 100.0 100
MAP4K2 MAP4K2 78.3 100
MAP4K3 MAP4K3 84.5 100
MAP4K4 MAP4K4 88.5 100
MAP4K5 MAP4K5 86.8 100
MAPKAPK2 MAPKAPK2 100.0 100
MAPKAPK5 MAPKAPK5 80.0 100
MARK1 MARK1 97.0 100
MARK2 MARK2 100.0 100
MARK3 MARK3 100.0 100
MARK4 MARK4 96.0 100
MAST1 MAST1 93.9 100
MAP2K1 MEK1 79.8 100
MAP2K2 MEK2 84.8 100
MAP2K3 MEK3 77.0 100
MAP2K4 MEK4 89.2 100
MAP2K5 MEK5 89.1 100
MAP2K6 MEK6 81.4 100
MELK MELK 58.7 100
MERTK MERTK 100.0 100
MET MET(Y1235D) 90.5 100
MINK1 MINK 90.1 100
MAP2K7 MKK7 89.4 100
MKNK1 MKNK1 89.6 100
MKNK2 MKNK2 90.6 100
MYLK3 MLCK 100.0 100
MAP3K9 MLK1 95.7 100
MAP3K10 MLK2 100.0 100
MAP3K11 MLK3 100.0 100
CDC42BPA MRCKA 86.5 100
CDC42BPB MRCKB 99.8 100
STK4 MST1 100.0 100
MST1R MST1R 94.4 100
STK3 MST2 90.2 100
STK24 MST3 100.0 100
STK26 MST4 94.9 100
MTOR MTOR 71.8 100
MUSK MUSK 86.8 100
MYLK MYLK 83.5 100
MYLK2 MYLK2 100.0 100
MYLK4 MYLK4 99.5 100
MYO3A MYO3A 100.0 100
MYO3B MYO3B 82.5 100
STK38 NDR1 75.2 100
STK38L NDR2 72.7 100
NEK1 NEK1 74.1 100
NEK10 NEK10 100.0 100
NEK11 NEK11 83.4 100
NEK2 NEK2 100.0 100
NEK3 NEK3 79.6 100
NEK4 NEK4 86.6 100
NEK5 NEK5 97.6 100
NEK6 NEK6 98.9 100
NEK7 NEK7 76.9 100
NEK9 NEK9 77.5 100
MAP3K14 NIK 100.0 100
NIM1K NIM1 100.0 100
NLK NLK 100.0 100
OXSR1 OSR1 69.8 100
MAPK14 p38-alpha 100.0 100 = 4.8
MAPK11 p38-beta 100.0 100 = 4.8
MAPK13 p38-delta 100.0 100 = 4.8
MAPK12 p38-gamma 80.7 100 = 4.8
PAK1 PAK1 79.1 100
PAK2 PAK2 86.3 100
PAK3 PAK3 100.0 100
PAK4 PAK4 93.7 100
PAK6 PAK6 63.5 100
PAK5 PAK7 88.7 100
CDK16 PCTK1 82.2 100
CDK17 PCTK2 95.9 100
CDK18 PCTK3 100.0 100
PDGFRA PDGFRA 87.3 100
PDGFRB PDGFRB 95.8 100
PDPK1 PDPK1 100.0 100
CDPK1 PFCDPK1(P.falciparum) 82.9 100
PK5 PFPK5(P.falciparum) 80.1 100
CDK15 PFTAIRE2 80.6 100
CDK14 PFTK1 100.0 100
PHKG1 PHKG1 84.1 100
PHKG2 PHKG2 78.8 100
PIK3C2B PIK3C2B 85.7 100
PIK3C2G PIK3C2G 68.3 100
PIK3CA PIK3CA(Q546K) 100.0 100
PIK3CB PIK3CB 81.5 100
PIK3CD PIK3CD 81.9 100
PIK3CG PIK3CG 96.4 100
PI4KB PIK4CB 82.1 100
PIKFYVE PIKFYVE 76.7 100
PIM1 PIM1 90.3 100
PIM2 PIM2 100.0 100
PIM3 PIM3 82.9 100
PIP5K1A PIP5K1A 84.5 100
PIP5K1C PIP5K1C 89.9 100
PIP4K2B PIP5K2B 45.0 100
PIP4K2C PIP5K2C 95.0 100
PRKACA PKAC-alpha 91.8 100
PRKACB PKAC-beta 77.0 100
PKMYT1 PKMYT1 99.6 100
PKN1 PKN1 89.3 100
PKN2 PKN2 83.4 100
PKNB PKNB(M.tuberculosis) 85.0 100
PLK1 PLK1 58.4 100
PLK2 PLK2 95.1 100
PLK3 PLK3 89.0 100
PLK4 PLK4 71.6 100
PRKCD PRKCD 94.9 100
PRKCE PRKCE 85.0 100
PRKCH PRKCH 90.1 100
PRKCI PRKCI 100.0 100
PRKCQ PRKCQ 100.0 100
PRKD1 PRKD1 100.0 100
PRKD2 PRKD2 97.5 100
PRKD3 PRKD3 100.0 100
PRKG1 PRKG1 52.4 100
PRKG2 PRKG2 76.1 100
EIF2AK2 PRKR 78.1 100
PRKX PRKX 46.1 100
PRPF4B PRP4 89.7 100
PTK2B PYK2 75.0 100
SIK3 QSK 79.6 100
RAF1 RAF1 100.0 100
RET RET(V804M) 100.0 100
RIOK1 RIOK1 100.0 100
RIOK2 RIOK2 84.6 100
RIOK3 RIOK3 100.0 100
RIPK1 RIPK1 100.0 100
RIPK2 RIPK2 90.3 100
RIPK4 RIPK4 76.0 100
DSTYK RIPK5 91.6 100
ROCK1 ROCK1 64.7 100 = 98.0
ROCK2 ROCK2 44.7 100 = 82.0
ROS1 ROS1 100.0 100
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 72.5 100
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 82.7 100
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 70.0 100
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 94.1 100
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 96.8 100
RPS6KB1 S6K1 90.0 100
SBK1 SBK1 53.3 100
SGK1 SGK 62.5 100
SBK3 SgK110 100.0 100
SGK2 SGK2 66.7 100
SGK3 SGK3 83.2 100
SIK1 SIK 100.0 100
SIK2 SIK2 85.7 100
SLK SLK 92.6 100
NUAK2 SNARK 76.0 100
SNRK SNRK 100.0 100
SRC SRC 94.6 100
SRMS SRMS 87.1 100
SRPK1 SRPK1 85.5 100
SRPK2 SRPK2 61.2 100
SRPK3 SRPK3 100.0 100
STK16 STK16 60.3 100
STK33 STK33 100.0 100
STK35 STK35 91.1 100
STK36 STK36 88.4 100
STK39 STK39 100.0 100
SYK SYK 100.0 100
MAP3K7 TAK1 82.6 100
TAOK1 TAOK1 66.4 100
TAOK2 TAOK2 74.7 100
TAOK3 TAOK3 73.0 100
TBK1 TBK1 84.8 100
TEC TEC 93.6 100
TESK1 TESK1 100.0 100
TGFBR1 TGFBR1 100.0 100
TGFBR2 TGFBR2 40.8 100 = 54.0
TIE1 TIE1 71.2 100
TEK TIE2 100.0 100
TLK1 TLK1 80.3 100
TLK2 TLK2 86.9 100
TNIK TNIK 95.8 100
TNK1 TNK1 98.1 100
TNK2 TNK2 94.8 100
TNNI3K TNNI3K 94.6 100
NTRK1 TRKA 90.0 100
NTRK2 TRKB 63.6 100
NTRK3 TRKC 76.7 100
TRPM6 TRPM6 96.4 100
TSSK1B TSSK1B 94.6 100
TSSK3 TSSK3 91.1 100
TTK TTK 85.2 100
TXK TXK 100.0 100
TYK2 TYK2(JH2domain-pseudokinase) 97.8 100
TYRO3 TYRO3 100.0 100
ULK1 ULK1 48.6 100 = 140.0
ULK2 ULK2 79.7 100
ULK3 ULK3 68.1 100
KDR VEGFR2 100.0 100
PIK3C3 VPS34 71.2 100
VRK2 VRK2 76.3 100
WEE1 WEE1 98.9 100
WEE2 WEE2 77.6 100
WNK1 WNK1 90.8 100
WNK2 WNK2 100.0 100
WNK3 WNK3 47.3 100
WNK4 WNK4 100.0 100
STK32A YANK1 100.0 100
STK32B YANK2 96.6 100
STK32C YANK3 100.0 100
YES1 YES 96.9 100
STK25 YSK1 61.5 100
MAP3K19 YSK4 86.2 100
MAP3K20 ZAK 100.0 100
ZAP70 ZAP70 95.8 100

ERKi-NC


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 72.8 1000
ABL2 ABL2 100.0 1000
ACVR1 ACVR1 81.8 1000
ACVR1B ACVR1B 76.1 1000
ACVR2A ACVR2A 85.6 1000
ACVR2B ACVR2B 86.2 1000
ACVRL1 ACVRL1 92.3 1000
COQ8A ADCK3 96.3 1000
COQ8B ADCK4 99.8 1000
AKT1 AKT1 90.0 1000
AKT2 AKT2 100.0 1000
AKT3 AKT3 100.0 1000
ALK ALK(L1196M) 100.0 1000
PRKAA1 AMPK-alpha1 100.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 100.0 1000
NUAK1 ARK5 100.0 1000
MAP3K5 ASK1 100.0 1000
MAP3K6 ASK2 67.4 1000
AURKA AURKA 100.0 1000
AURKB AURKB 79.8 1000
AURKC AURKC 100.0 1000
AXL AXL 100.0 1000
BMP2K BIKE 100.0 1000
BLK BLK 100.0 1000
BMPR1A BMPR1A 74.6 1000
BMPR1B BMPR1B 100.0 1000
BMPR2 BMPR2 100.0 1000
BMX BMX 91.7 1000
BRAF BRAF(V600E) 100.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 100.0 1000
BRSK2 BRSK2 88.0 1000
BTK BTK 92.0 1000
BUB1 BUB1 100.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 98.5 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 100.0 1000
CAMK2B CAMK2B 100.0 1000
CAMK2D CAMK2D 81.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 96.4 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 85.4 1000
CASK CASK 60.8 1000
CDK11B CDC2L1 94.2 1000
CDK11A CDC2L2 95.4 1000
CDK13 CDC2L5 79.0 1000
CDK19 CDK11 71.3 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 100.0 1000
CDK7 CDK7 100.0 1000
CDK8 CDK8 100.0 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 78.8 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 100.0 1000
CDKL5 CDKL5 100.0 1000
CHEK1 CHEK1 100.0 1000
CHEK2 CHEK2 95.9 1000
CIT CIT 99.9 1000
CLK1 CLK1 94.4 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 78.8 1000
CSF1R CSF1R-autoinhibited 94.8 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 56.5 1000
CSNK1A1L CSNK1A1L 100.0 1000
CSNK1D CSNK1D 100.0 1000
CSNK1E CSNK1E 96.1 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 100.0 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 100.0 1000
CSNK2A2 CSNK2A2 100.0 1000
MATK CTK 100.0 1000
DAPK1 DAPK1 100.0 1000
DAPK2 DAPK2 100.0 1000
DAPK3 DAPK3 100.0 1000
DCLK1 DCAMKL1 71.1 1000
DCLK2 DCAMKL2 100.0 1000
DCLK3 DCAMKL3 84.5 1000
DDR1 DDR1 74.7 1000
DDR2 DDR2 94.3 1000
MAP3K12 DLK 67.9 1000
DMPK DMPK 100.0 1000
CDC42BPG DMPK2 100.0 1000
STK17A DRAK1 100.0 1000
STK17B DRAK2 100.0 1000
DYRK1A DYRK1A 100.0 1000
DYRK1B DYRK1B 57.6 1000
DYRK2 DYRK2 100.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 100.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 100.0 1000
EPHA4 EPHA4 61.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 89.0 1000
EPHA7 EPHA7 97.3 1000
EPHA8 EPHA8 100.0 1000
EPHB1 EPHB1 100.0 1000
EPHB2 EPHB2 100.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 100.0 1000
ERBB2 ERBB2 100.0 1000
ERBB3 ERBB3 60.6 1000
ERBB4 ERBB4 100.0 1000
MAPK3 ERK1 17.0 1000
MAPK1 ERK2 50.0 1000
MAPK6 ERK3 100.0 1000
MAPK4 ERK4 84.7 1000
MAPK7 ERK5 87.9 1000
MAPK15 ERK8 100.0 1000
ERN1 ERN1 100.0 1000
PTK2 FAK 100.0 1000
FER FER 88.8 1000
FES FES 100.0 1000
FGFR1 FGFR1 78.0 1000
FGFR2 FGFR2 62.0 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 100.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 100.0 1000
FLT3 FLT3-autoinhibited 100.0 1000
FLT4 FLT4 100.0 1000
FRK FRK 100.0 1000
FYN FYN 70.9 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 77.2 1000
GRK1 GRK1 59.5 1000
GRK2 GRK2 79.3 1000
GRK3 GRK3 88.7 1000
GRK4 GRK4 85.2 1000
GRK7 GRK7 100.0 1000
GSK3A GSK3A 100.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 72.1 1000
HCK HCK 100.0 1000
HIPK1 HIPK1 48.9 1000
HIPK2 HIPK2 83.9 1000
HIPK3 HIPK3 85.1 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 93.8 1000
HUNK HUNK 100.0 1000
CILK1 ICK 71.4 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 100.0 1000
IKBKB IKK-beta 100.0 1000
IKBKE IKK-epsilon 100.0 1000
INSR INSR 100.0 1000
INSRR INSRR 100.0 1000
IRAK1 IRAK1 100.0 1000
IRAK3 IRAK3 99.3 1000
IRAK4 IRAK4 100.0 1000
ITK ITK 100.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 42.4 1000
JAK2 JAK2(JH1domain-catalytic) 100.0 1000
JAK3 JAK3(JH1domain-catalytic) 100.0 1000
MAPK8 JNK1 63.3 1000
MAPK9 JNK2 100.0 1000
MAPK10 JNK3 74.6 1000
KIT KIT-autoinhibited 71.5 1000
LATS1 LATS1 100.0 1000
LATS2 LATS2 100.0 1000
LCK LCK 81.5 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 96.0 1000
STK11 LKB1 100.0 1000
STK10 LOK 95.5 1000
LRRK2 LRRK2(G2019S) 88.8 1000
LTK LTK 100.0 1000
LYN LYN 100.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 84.1 1000
MAP3K1 MAP3K1 95.1 1000
MAP3K15 MAP3K15 100.0 1000
MAP3K2 MAP3K2 98.4 1000
MAP3K3 MAP3K3 100.0 1000
MAP3K4 MAP3K4 53.1 1000
MAP4K2 MAP4K2 100.0 1000
MAP4K3 MAP4K3 100.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 99.6 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 100.0 1000
MARK1 MARK1 78.7 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 89.6 1000
MARK4 MARK4 100.0 1000
MAST1 MAST1 100.0 1000
MAP2K1 MEK1 97.6 1000
MAP2K2 MEK2 90.7 1000
MAP2K3 MEK3 76.3 1000
MAP2K4 MEK4 88.9 1000
MAP2K5 MEK5 17.6 1000
MAP2K6 MEK6 100.0 1000
MELK MELK 100.0 1000
MERTK MERTK 100.0 1000
MET MET(Y1235D) 100.0 1000
MINK1 MINK 77.7 1000
MAP2K7 MKK7 94.1 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 82.6 1000
MYLK3 MLCK 100.0 1000
MAP3K9 MLK1 100.0 1000
MAP3K10 MLK2 100.0 1000
MAP3K11 MLK3 87.7 1000
CDC42BPA MRCKA 93.5 1000
CDC42BPB MRCKB 100.0 1000
STK4 MST1 100.0 1000
MST1R MST1R 85.5 1000
STK3 MST2 82.2 1000
STK24 MST3 98.0 1000
STK26 MST4 100.0 1000
MTOR MTOR 93.1 1000
MUSK MUSK 100.0 1000
MYLK MYLK 100.0 1000
MYLK2 MYLK2 76.6 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 67.6 1000
STK38 NDR1 81.4 1000
STK38L NDR2 100.0 1000
NEK1 NEK1 100.0 1000
NEK10 NEK10 53.8 1000
NEK11 NEK11 57.7 1000
NEK2 NEK2 96.9 1000
NEK3 NEK3 46.8 1000
NEK4 NEK4 83.9 1000
NEK5 NEK5 84.3 1000
NEK6 NEK6 100.0 1000
NEK7 NEK7 98.0 1000
NEK9 NEK9 100.0 1000
MAP3K14 NIK 85.0 1000
NIM1K NIM1 100.0 1000
NLK NLK 66.3 1000
OXSR1 OSR1 100.0 1000
MAPK14 p38-alpha 100.0 1000
MAPK11 p38-beta 100.0 1000
MAPK13 p38-delta 85.0 1000
MAPK12 p38-gamma 48.4 1000
PAK1 PAK1 100.0 1000
PAK2 PAK2 94.3 1000
PAK3 PAK3 100.0 1000
PAK4 PAK4 90.2 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 100.0 1000
CDK17 PCTK2 78.0 1000
CDK18 PCTK3 100.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 100.0 1000
PDPK1 PDPK1 86.3 1000
CDPK1 PFCDPK1(P.falciparum) 77.4 1000
PK5 PFPK5(P.falciparum) 91.1 1000
CDK15 PFTAIRE2 97.4 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 96.3 1000
PHKG2 PHKG2 100.0 1000
PIK3C2B PIK3C2B 100.0 1000
PIK3C2G PIK3C2G 93.1 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 100.0 1000
PIK3CD PIK3CD 100.0 1000
PIK3CG PIK3CG 100.0 1000
PI4KB PIK4CB 100.0 1000
PIKFYVE PIKFYVE 100.0 1000
PIM1 PIM1 78.2 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 100.0 1000
PIP5K1C PIP5K1C 99.3 1000
PIP4K2B PIP5K2B 99.5 1000
PIP4K2C PIP5K2C 100.0 1000
PRKACA PKAC-alpha 87.7 1000
PRKACB PKAC-beta 91.5 1000
PKMYT1 PKMYT1 100.0 1000
PKN1 PKN1 93.1 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 100.0 1000
PLK1 PLK1 92.1 1000
PLK2 PLK2 100.0 1000
PLK3 PLK3 68.7 1000
PLK4 PLK4 100.0 1000
PRKCD PRKCD 63.8 1000
PRKCE PRKCE 100.0 1000
PRKCH PRKCH 95.4 1000
PRKCI PRKCI 85.5 1000
PRKCQ PRKCQ 100.0 1000
PRKD1 PRKD1 89.4 1000
PRKD2 PRKD2 100.0 1000
PRKD3 PRKD3 100.0 1000
PRKG1 PRKG1 90.7 1000
PRKG2 PRKG2 100.0 1000
EIF2AK2 PRKR 71.8 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 100.0 1000
PTK2B PYK2 100.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 90.2 1000
RET RET(V804M) 81.7 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 100.0 1000
RIOK3 RIOK3 90.7 1000
RIPK1 RIPK1 100.0 1000
RIPK2 RIPK2 77.0 1000
RIPK4 RIPK4 100.0 1000
DSTYK RIPK5 100.0 1000
ROCK1 ROCK1 66.0 1000
ROCK2 ROCK2 88.4 1000
ROS1 ROS1 85.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 80.7 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 95.3 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 82.7 1000
RPS6KB1 S6K1 58.3 1000
SBK1 SBK1 100.0 1000
SGK1 SGK 97.4 1000
SBK3 SgK110 100.0 1000
SGK2 SGK2 100.0 1000
SGK3 SGK3 93.6 1000
SIK1 SIK 100.0 1000
SIK2 SIK2 94.0 1000
SLK SLK 76.0 1000
NUAK2 SNARK 100.0 1000
SNRK SNRK 100.0 1000
SRC SRC 100.0 1000
SRMS SRMS 84.0 1000
SRPK1 SRPK1 100.0 1000
SRPK2 SRPK2 100.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 100.0 1000
STK35 STK35 100.0 1000
STK36 STK36 97.3 1000
STK39 STK39 80.9 1000
SYK SYK 100.0 1000
MAP3K7 TAK1 100.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 82.3 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 48.3 1000
TEC TEC 100.0 1000
TESK1 TESK1 100.0 1000
TGFBR1 TGFBR1 60.8 1000
TGFBR2 TGFBR2 76.1 1000
TIE1 TIE1 86.8 1000
TEK TIE2 71.1 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 88.4 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 87.8 1000
TNK2 TNK2 100.0 1000
TNNI3K TNNI3K 100.0 1000
NTRK1 TRKA 81.0 1000
NTRK2 TRKB 68.5 1000
NTRK3 TRKC 85.4 1000
TRPM6 TRPM6 92.7 1000
TSSK1B TSSK1B 99.0 1000
TSSK3 TSSK3 100.0 1000
TTK TTK 80.3 1000
TXK TXK 51.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 100.0 1000
TYRO3 TYRO3 59.2 1000
ULK1 ULK1 100.0 1000
ULK2 ULK2 100.0 1000
ULK3 ULK3 98.9 1000
KDR VEGFR2 100.0 1000
PIK3C3 VPS34 97.0 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 100.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 100.0 1000
WNK2 WNK2 90.7 1000
WNK3 WNK3 100.0 1000
WNK4 WNK4 100.0 1000
STK32A YANK1 100.0 1000
STK32B YANK2 100.0 1000
STK32C YANK3 74.0 1000
YES1 YES 100.0 1000
STK25 YSK1 100.0 1000
MAP3K19 YSK4 100.0 1000
MAP3K20 ZAK 74.7 1000
ZAP70 ZAP70 77.9 1000

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