In cells

Use MRK-ERKi at a concentration of 1 µM in cell-based experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat (1 mg/kg (po); 0.5 mg/kg (iv)) and dog (0.5 mg/kg (po); 0.25 mg/kg (iv))