Selectivity data for probe JNJ-78911118 and control JNJ-77914993
Coming soon
JNJ-78911118
Shown are supplemental data from PMID: 40361296.
Conclusion: Clean panel.
| Target protein | HGNC name | Species | % effect at 1 µM |
|---|---|---|---|
| AAK1(h) | AAK1 | Homo sapiens | 113.0 |
| Abl(h) | ABL1 | Homo sapiens | 105.0 |
| ACK1(h) | TNK2 | Homo sapiens | 93.0 |
| ACTR2(h) | ACTR2 | Homo sapiens | 97.0 |
| ALK(h) | ALK | Homo sapiens | 125.0 |
| ALK1(h) | ACVRL1 | Homo sapiens | 103.0 |
| ALK2(h) | ACVR1 | Homo sapiens | 95.0 |
| ALK4(h) | ACVR1B | Homo sapiens | 112.0 |
| ALK6(h) | BMPR1B | Homo sapiens | 90.0 |
| AMPKα1(h) | PRKAA1 | Homo sapiens | 106.0 |
| AMPKα2(h) | PRKAA2 | Homo sapiens | 111.0 |
| A-Raf(h) | ARAF | Homo sapiens | 96.0 |
| Arg(h) | ABL2 | Homo sapiens | 101.0 |
| ARK5(h) | NUAK1 | Homo sapiens | 96.0 |
| ASK1(h) | MAP3K5 | Homo sapiens | 106.0 |
| ATM(h) | ATM | Homo sapiens | 104.0 |
| ATR/ATRIP(h) |
ATR ATRIP |
Homo sapiens | 93.0 |
| Aurora-A(h) | AURKA | Homo sapiens | 107.0 |
| Aurora-B(h) | AURKB | Homo sapiens | 84.0 |
| Aurora-C(h) | AURKC | Homo sapiens | 108.0 |
| Axl(h) | AXL | Homo sapiens | 106.0 |
| BIKe(h) | BMP2K | Homo sapiens | 100.0 |
| Blk(h) | BLK | Homo sapiens | 93.0 |
| BMPR2(h) | BMPR2 | Homo sapiens | 105.0 |
| Bmx(h) | BMX | Homo sapiens | 100.0 |
| B-Raf(h) | BRAF | Homo sapiens | 110.0 |
| BRK(h) | PTK6 | Homo sapiens | 92.0 |
| BrSK1(h) | BRSK1 | Homo sapiens | 102.0 |
| BrSK2(h) | BRSK2 | Homo sapiens | 100.0 |
| BTK(h) | BTK | Homo sapiens | 111.0 |
| CaMKI(h) | CAMK1 | Homo sapiens | 106.0 |
| CaMKIIalpha(h) | CAMK2A | Homo sapiens | 102.0 |
| CaMKIIbeta(h) | CAMK2B | Homo sapiens | 97.0 |
| CaMKIIgamma(h) | CAMK2G | Homo sapiens | 94.0 |
| CaMKIIdelta(h) | CAMK2D | Homo sapiens | 111.0 |
| CaMKIbeta(h) | PNCK | Homo sapiens | 113.0 |
| CaMKIV(h) | CAMK4 | Homo sapiens | 89.0 |
| CaMKIgamma(h) | CAMK1G | Homo sapiens | 107.0 |
| CaMKIdelta(h) | CAMK1D | Homo sapiens | 99.0 |
| CaMKK1(h) | CAMKK1 | Homo sapiens | 102.0 |
| CaMKK2(h) | CAMKK2 | Homo sapiens | 111.0 |
| Cdc7/cyclinB1(h) |
CDC7 CCNB1 |
Homo sapiens | 118.0 |
| CDK1/cyclinB(h) |
CDK1 CCNB1 |
Homo sapiens | 101.0 |
| CDK12/cyclinK(h) |
CDK12 CCNK |
Homo sapiens | 99.0 |
| CDK13/cyclinK(h) |
CDK13 CCNK |
Homo sapiens | 95.0 |
| CDK14/cyclinY(h) |
CDK14 CCNY |
Homo sapiens | 109.0 |
| CDK16/cyclinY(h) |
CDK16 CCNY |
Homo sapiens | 83.0 |
| CDK17/cyclinY(h) |
CDK17 CCNY |
Homo sapiens | 94.0 |
| CDK18/cyclinY(h) |
CDK18 CCNY |
Homo sapiens | 79.0 |
| CDK2/cyclinA(h) |
CDK2 CCNA2 |
Homo sapiens | 77.0 |
| CDK2/cyclinE(h) |
CDK2 CCNE1 |
Homo sapiens | 109.0 |
| CDK3/cyclinE(h) |
CDK3 CCNE1 |
Homo sapiens | 93.0 |
| CDK4/cyclinD3(h) |
CDK4 CCND3 |
Homo sapiens | 105.0 |
| CDK5/p35(h) |
CDK5 CDK5R1 |
Homo sapiens | 103.0 |
| CDK6/cyclinD3(h) |
CDK6 CCND3 |
Homo sapiens | 109.0 |
| CDK7/cyclinH/MAT1(h) |
CDK7 CCNH MNAT1 |
Homo sapiens | 75.0 |
| CDK9/cyclin T1(h) |
CDK9 CCNT1 |
Homo sapiens | 103.0 |
| CDKL1(h) | CDKL1 | Homo sapiens | 93.0 |
| CDKL2(h) | CDKL2 | Homo sapiens | 125.0 |
| CDKL3(h) | CDKL3 | Homo sapiens | 116.0 |
| CDKL4(h) | CDKL4 | Homo sapiens | 111.0 |
| ChaK1(h) | TRPM7 | Homo sapiens | 111.0 |
| CHK1(h) | CHEK1 | Homo sapiens | 80.0 |
| CHK2(h) | CHEK2 | Homo sapiens | 89.0 |
| CK1α(h) | CSNK1A1 | Homo sapiens | 103.0 |
| CK1gamma1(h) | CSNK1G1 | Homo sapiens | 99.0 |
| CK1gamma2(h) | CSNK1G2 | Homo sapiens | 113.0 |
| CK1gamma3(h) | CSNK1G3 | Homo sapiens | 107.0 |
| CK1delta(h) | CSNK1D | Homo sapiens | 112.0 |
| CK1epsilon(h) | CSNK1E | Homo sapiens | 99.0 |
| CK2(h) | Homo sapiens | 88.0 | |
| CK2alpha1(h) | CSNK2A1 | Homo sapiens | 97.0 |
| CK2alpha2(h) | CSNK2A2 | Homo sapiens | 112.0 |
| cKit(h) | KIT | Homo sapiens | 95.0 |
| CLIK1(h) | STK35 | Homo sapiens | 109.0 |
| CLK1(h) | CLK1 | Homo sapiens | 108.0 |
| CLK2(h) | CLK2 | Homo sapiens | 91.0 |
| CLK3(h) | CLK3 | Homo sapiens | 114.0 |
| CLK4(h) | CLK4 | Homo sapiens | 110.0 |
| c-RAF(h) | RAF1 | Homo sapiens | 96.0 |
| CRIK(h) | CIT | Homo sapiens | 103.0 |
| CSK(h) | CSK | Homo sapiens | 86.0 |
| cSRC(h) | SRC | Homo sapiens | 87.0 |
| DAPK1(h) | DAPK1 | Homo sapiens | 101.0 |
| DAPK2(h) | DAPK2 | Homo sapiens | 107.0 |
| DCAMKL1(h) | DCLK1 | Homo sapiens | 95.0 |
| DCAMKL2(h) | DCLK2 | Homo sapiens | 81.0 |
| DCAMKL3(h) | DCLK3 | Homo sapiens | 88.0 |
| DDR1(h) | DDR1 | Homo sapiens | 93.0 |
| DDR2(h) | DDR2 | Homo sapiens | 105.0 |
| DMPK(h) | DMPK | Homo sapiens | 105.0 |
| DNA-PK(h) | PRKDC | Homo sapiens | 93.0 |
| DRAK1(h) | STK17A | Homo sapiens | 99.0 |
| DRAK2(h) | STK17B | Homo sapiens | 92.0 |
| DYRK1A(h) | DYRK1A | Homo sapiens | 105.0 |
| DYRK1B(h) | DYRK1B | Homo sapiens | 98.0 |
| DYRK2(h) | DYRK2 | Homo sapiens | 97.0 |
| DYRK3(h) | DYRK3 | Homo sapiens | 104.0 |
| eEF2K(h) | EEF2K | Homo sapiens | 105.0 |
| EGFR(h) | EGFR | Homo sapiens | 95.0 |
| EphA1(h) | EPHA1 | Homo sapiens | 96.0 |
| EphA2(h) | EPHA2 | Homo sapiens | 97.0 |
| EphA3(h) | EPHA3 | Homo sapiens | 93.0 |
| EphA4(h) | EPHA4 | Homo sapiens | 98.0 |
| EphA5(h) | EPHA5 | Homo sapiens | 84.0 |
| EphA7(h) | EPHA7 | Homo sapiens | 95.0 |
| EphA8(h) | EPHA8 | Homo sapiens | 104.0 |
| EphB1(h) | EPHB1 | Homo sapiens | 89.0 |
| EphB2(h) | EPHB2 | Homo sapiens | 96.0 |
| EphB3(h) | EPHB3 | Homo sapiens | 107.0 |
| EphB4(h) | EPHB4 | Homo sapiens | 118.0 |
| ErbB2(h) | ERBB2 | Homo sapiens | 98.0 |
| ErbB4(h) | ERBB4 | Homo sapiens | 106.0 |
| FAK(h) | PTK2 | Homo sapiens | 101.0 |
| Fer(h) | FER | Homo sapiens | 93.0 |
| Fes(h) | FES | Homo sapiens | 95.0 |
| FGFR1(h) | FGFR1 | Homo sapiens | 98.0 |
| FGFR2(h) | FGFR2 | Homo sapiens | 98.0 |
| FGFR3(h) | FGFR3 | Homo sapiens | 102.0 |
| FGFR4(h) | FGFR4 | Homo sapiens | 95.0 |
| Fgr(h) | FGR | Homo sapiens | 116.0 |
| Flt1(h) | FLT1 | Homo sapiens | 145.0 |
| Flt3(h) | FLT3 | Homo sapiens | 102.0 |
| Flt4(h) | FLT4 | Homo sapiens | 95.0 |
| Fms(h) | CSF1R | Homo sapiens | 108.0 |
| Fyn(h) | FYN | Homo sapiens | 93.0 |
| GCK(h) | GCK | Homo sapiens | 103.0 |
| GCN2(h) | EIF2AK4 | Homo sapiens | 97.0 |
| GRK1(h) | GRK1 | Homo sapiens | 117.0 |
| GRK2(h) | GRK2 | Homo sapiens | 90.0 |
| GRK3(h) | GRK3 | Homo sapiens | 89.0 |
| GRK5(h) | GRK5 | Homo sapiens | 89.0 |
| GRK6(h) | GRK6 | Homo sapiens | 114.0 |
| GRK7(h) | GRK7 | Homo sapiens | 107.0 |
| GSK3alpha(h) | GSK3A | Homo sapiens | 104.0 |
| GSK3beta(h) | GSK3B | Homo sapiens | 132.0 |
| Haspin(h) | HASPIN | Homo sapiens | 96.0 |
| Hck(h) | HCK | Homo sapiens | 89.0 |
| Hck(h) activated | HCK | Homo sapiens | 111.0 |
| HIPK1(h) | HIPK1 | Homo sapiens | 106.0 |
| HIPK2(h) | HIPK2 | Homo sapiens | 100.0 |
| HIPK3(h) | HIPK3 | Homo sapiens | 84.0 |
| HIPK4(h) | HIPK4 | Homo sapiens | 94.0 |
| HPK1(h) | MAP4K1 | Homo sapiens | 100.0 |
| HRI(h) | EIF2AK1 | Homo sapiens | 119.0 |
| ICK(h) | CILK1 | Homo sapiens | 97.0 |
| IGF1R(h) | IGF1R | Homo sapiens | 109.0 |
| IGF1R(h), activated | IGF1R | Homo sapiens | 99.0 |
| IKKalpha(h) | CHUK | Homo sapiens | 101.0 |
| IKKbeta(h) | IKBKB | Homo sapiens | 96.0 |
| IKKepsilon(h) | IKBKE | Homo sapiens | 113.0 |
| IR(h) | INSR | Homo sapiens | 113.0 |
| IR(h), activated | INSR | Homo sapiens | 93.0 |
| IRAK1(h) | IRAK1 | Homo sapiens | 109.0 |
| IRAK4(h) | IRAK4 | Homo sapiens | 89.0 |
| IRE1(h) | ERN1 | Homo sapiens | 101.0 |
| IRR(h) | INSRR | Homo sapiens | 102.0 |
| Itk(h) | ITK | Homo sapiens | 89.0 |
| JAK1(h) | JAK1 | Homo sapiens | 104.0 |
| JAK2(h) | JAK2 | Homo sapiens | 103.0 |
| JAK3(h) | JAK3 | Homo sapiens | 107.0 |
| JNK1alpha1(h) | MAPK8 | Homo sapiens | 94.0 |
| JNK2alpha2(h) | MAPK9 | Homo sapiens | 109.0 |
| JNK3(h) | MAPK10 | Homo sapiens | 85.0 |
| KDR(h) | KDR | Homo sapiens | 87.0 |
| LATS1(h) | LATS1 | Homo sapiens | 113.0 |
| LATS2(h) | LATS2 | Homo sapiens | 103.0 |
| Lck(h) | LCK | Homo sapiens | 120.0 |
| Lck(h) activated | LCK | Homo sapiens | 112.0 |
| LIMK1(h) | LIMK1 | Homo sapiens | 100.0 |
| LIMK2(h) | LIMK2 | Homo sapiens | 104.0 |
| LKB1(h) | STK11 | Homo sapiens | 97.0 |
| LOK(h) | STK10 | Homo sapiens | 100.0 |
| LRRK2(h) | LRRK2 | Homo sapiens | 105.0 |
| LTK(h) | LTK | Homo sapiens | 107.0 |
| Lyn(h) | LYN | Homo sapiens | 109.0 |
| MAK(h) | MAK | Homo sapiens | 111.0 |
| MAP4K3(h) | MAP4K3 | Homo sapiens | 94.0 |
| MAP4K4(h) | MAP4K4 | Homo sapiens | 95.0 |
| MAP4K5(h) | MAP4K5 | Homo sapiens | 94.0 |
| MAPK1(h) | MAPK1 | Homo sapiens | 91.0 |
| MAPK2(h) | Homo sapiens | 90.0 | |
| MAPKAP-K2(h) | MAPKAPK2 | Homo sapiens | 95.0 |
| MAPKAP-K3(h) | MAPKAPK3 | Homo sapiens | 89.0 |
| MARK1(h) | MARK1 | Homo sapiens | 106.0 |
| MARK3(h) | MARK3 | Homo sapiens | 109.0 |
| MARK4(h) | MARK4 | Homo sapiens | 95.0 |
| MEK1(h) | MAP2K1 | Homo sapiens | 105.0 |
| MEK2(h) | MAP2K2 | Homo sapiens | 84.0 |
| MEKK2(h) | MAP3K2 | Homo sapiens | 106.0 |
| MEKK3(h) | MAP3K3 | Homo sapiens | 98.0 |
| MELK(h) | MELK | Homo sapiens | 105.0 |
| Mer(h) | MERTK | Homo sapiens | 97.0 |
| Met(h) | MET | Homo sapiens | 98.0 |
| MINK(h) | MINK1 | Homo sapiens | 105.0 |
| MKK3(h) | MAP2K3 | Homo sapiens | 115.0 |
| MKK6(h) | MAP2K6 | Homo sapiens | 111.0 |
| MLCK(h) | MYLK3 | Homo sapiens | 93.0 |
| MLK1(h) | MAP3K9 | Homo sapiens | 87.0 |
| MLK2(h) | MAP3K10 | Homo sapiens | 94.0 |
| MLK3(h) | MAP3K11 | Homo sapiens | 99.0 |
| MLK4(h) | MAP3K21 | Homo sapiens | 85.0 |
| Mnk2(h) | MKNK2 | Homo sapiens | 106.0 |
| MOK(h) | MOK | Homo sapiens | 103.0 |
| MRCKalpha(h) | CDC42BPA | Homo sapiens | 97.0 |
| MRCKbeta(h) | CDC42BPB | Homo sapiens | 108.0 |
| MRCKgamma(h) | CDC42BPG | Homo sapiens | 88.0 |
| MSK1(h) | RPS6KA5 | Homo sapiens | 108.0 |
| MSK2(h) | RPS6KA4 | Homo sapiens | 91.0 |
| MSSK1(h) | SRPK3 | Homo sapiens | 102.0 |
| MST1(h) | STK4 | Homo sapiens | 92.0 |
| MST2(h) | STK3 | Homo sapiens | 93.0 |
| MST3(h) | STK24 | Homo sapiens | 96.0 |
| MST4(h) | STK26 | Homo sapiens | 105.0 |
| mTOR(h) | MTOR | Homo sapiens | 92.0 |
| mTOR/FKBP12(h) |
MTOR FKBP1A |
Homo sapiens | 102.0 |
| MuSK(h) | MUSK | Homo sapiens | 90.0 |
| MYLK2(h) | MYLK2 | Homo sapiens | 105.0 |
| MYO3B(h) | MYO3B | Homo sapiens | 94.0 |
| NDR1(h) | STK38 | Homo sapiens | 110.0 |
| NDR2(h) | STK38L | Homo sapiens | 95.0 |
| NEK1(h) | NEK1 | Homo sapiens | 107.0 |
| NEK11(h) | NEK11 | Homo sapiens | 106.0 |
| NEK2(h) | NEK2 | Homo sapiens | 97.0 |
| NEK3(h) | NEK3 | Homo sapiens | 110.0 |
| NEK4(h) | NEK4 | Homo sapiens | 112.0 |
| NEK6(h) | NEK6 | Homo sapiens | 105.0 |
| NEK7(h) | NEK7 | Homo sapiens | 107.0 |
| NEK9(h) | NEK9 | Homo sapiens | 119.0 |
| NIM1(h) | NIM1K | Homo sapiens | 105.0 |
| NLK(h) | NLK | Homo sapiens | 103.0 |
| NUAK2(h) | NUAK2 | Homo sapiens | 96.0 |
| OSR1(h) | OXSR1 | Homo sapiens | 102.0 |
| p70S6K(h) | Homo sapiens | 99.0 | |
| PAK1(h) | PAK1 | Homo sapiens | 101.0 |
| PAK2(h) | PAK2 | Homo sapiens | 92.0 |
| PAK3(h) | PAK3 | Homo sapiens | 105.0 |
| PAK4(h) | PAK4 | Homo sapiens | 138.0 |
| PAK5(h) | PAK5 | Homo sapiens | 106.0 |
| PAK6(h) | PAK6 | Homo sapiens | 99.0 |
| PAR-1Balpha(h) | MARK2 | Homo sapiens | 99.0 |
| PASK(h) | PASK | Homo sapiens | 106.0 |
| PDGFRalpha(h) | PDGFRA | Homo sapiens | 97.0 |
| PDGFRbeta(h) | PDGFRB | Homo sapiens | 90.0 |
| PDHK2(h) | PDK2 | Homo sapiens | 105.0 |
| PDHK4(h) | PDK4 | Homo sapiens | 95.0 |
| PDK1(h) | PDK1 | Homo sapiens | 97.0 |
| PEK(h) | EIF2AK3 | Homo sapiens | 107.0 |
| PhKgamma1(h) | PHKG1 | Homo sapiens | 112.0 |
| PhKgamma2(h) | PHKG2 | Homo sapiens | 95.0 |
| PI3 Kinase (p110alpha/p85alpha)(h) |
PIK3CA PIK3R1 |
Homo sapiens | 100.0 |
| PI3 Kinase (p110beta/p85alpha)(h) |
PIK3CB PIK3R1 |
Homo sapiens | 93.0 |
| PI3 Kinase (p110delta/p85alpha)(h) |
PIK3CD PIK3R1 |
Homo sapiens | 103.0 |
| PI3 Kinase (p120gamma)(h) | PIK3CG | Homo sapiens | 94.0 |
| PI3KC2alpha(h) | PIK3C2A | Homo sapiens | 100.0 |
| PI3KC2gamma(h) | PIK3C2G | Homo sapiens | 103.0 |
| Pim-1(h) | PIM1 | Homo sapiens | 76.0 |
| Pim-2(h) | PIM2 | Homo sapiens | 115.0 |
| Pim-3(h) | PIM3 | Homo sapiens | 94.0 |
| PIP4K2alpha(h) | PIP4K2A | Homo sapiens | 106.0 |
| PIP5K1alpha(h) | PIP5K1A | Homo sapiens | 105.0 |
| PIP5K1gamma(h) | PIP5K1C | Homo sapiens | 97.0 |
| PKA(h) | Homo sapiens | 114.0 | |
| PKACbeta(h) | PRKACB | Homo sapiens | 94.0 |
| PKBalpha(h) | AKT1 | Homo sapiens | 93.0 |
| PKBbeta(h) | AKT2 | Homo sapiens | 86.0 |
| PKBgamma(h) | AKT3 | Homo sapiens | 103.0 |
| PKCalpha(h) | PRKCA | Homo sapiens | 110.0 |
| PKCbetaII(h) | PRKCB | Homo sapiens | 93.0 |
| PKCgamma(h) | PRKCG | Homo sapiens | 105.0 |
| PKCdelta(h) | PRKCD | Homo sapiens | 108.0 |
| PKCepsilon(h) | PRKCE | Homo sapiens | 104.0 |
| PKCzeta(h) | PRKCZ | Homo sapiens | 101.0 |
| PKCeta(h) | PRKCH | Homo sapiens | 120.0 |
| PKCtheta(h) | PRKCQ | Homo sapiens | 103.0 |
| PKCiota(h) | PRKCI | Homo sapiens | 91.0 |
| PKCmu(h) | PRKD1 | Homo sapiens | 104.0 |
| PKD2(h) | PRKD2 | Homo sapiens | 96.0 |
| PKD3(h) | PRKD3 | Homo sapiens | 102.0 |
| PKG1alpha(h) | PRKG1 | Homo sapiens | 126.0 |
| PKG1beta(h) | PRKG1 | Homo sapiens | 92.0 |
| PKR(h) | EIF2AK2 | Homo sapiens | 117.0 |
| Plk1(h) | PLK1 | Homo sapiens | 98.0 |
| Plk3(h) | PLK3 | Homo sapiens | 98.0 |
| Plk4(h) | PLK4 | Homo sapiens | 105.0 |
| PRAK(h) | MAPKAPK5 | Homo sapiens | 138.0 |
| PRK1(h) | PKN1 | Homo sapiens | 113.0 |
| PRK2(h) | PKN2 | Homo sapiens | 81.0 |
| PRKG2(h) | PRKG2 | Homo sapiens | 92.0 |
| PrKX(h) | PRKX | Homo sapiens | 108.0 |
| PRP4(h) | PRPF4B | Homo sapiens | 92.0 |
| PTK5(h) | FRK | Homo sapiens | 97.0 |
| Pyk2(h) | PTK2B | Homo sapiens | 107.0 |
| Ret(h) | RET | Homo sapiens | 113.0 |
| RIPK1(h) | RIPK1 | Homo sapiens | 109.0 |
| RIPK2(h) | RIPK2 | Homo sapiens | 107.0 |
| ROCK-I(h) | ROCK1 | Homo sapiens | 88.0 |
| ROCK-II(h) | ROCK2 | Homo sapiens | 93.0 |
| Ron(h) | MST1R | Homo sapiens | 99.0 |
| Ros(h) | ROS1 | Homo sapiens | 122.0 |
| Rse(h) | TYRO3 | Homo sapiens | 94.0 |
| Rsk1(h) | RPS6KA1 | Homo sapiens | 94.0 |
| Rsk2(h) | RPS6KA3 | Homo sapiens | 86.0 |
| Rsk3(h) | RPS6KA2 | Homo sapiens | 95.0 |
| Rsk4(h) | RPS6KA6 | Homo sapiens | 104.0 |
| SAPK2a(h) | MAPK14 | Homo sapiens | 95.0 |
| SAPK2b(h) | MAPK11 | Homo sapiens | 106.0 |
| SAPK3(h) | MAPK12 | Homo sapiens | 112.0 |
| SAPK4(h) | MAPK13 | Homo sapiens | 108.0 |
| SBK1(h) | SBK1 | Homo sapiens | 84.0 |
| SGK(h) | SGK1 | Homo sapiens | 79.0 |
| SGK2(h) | SGK2 | Homo sapiens | 122.0 |
| SGK3(h) | SGK3 | Homo sapiens | 90.0 |
| SIK(h) | SIK1 | Homo sapiens | 84.0 |
| SIK2(h) | SIK2 | Homo sapiens | 91.0 |
| SIK3(h) | SIK3 | Homo sapiens | 90.0 |
| SLK(h) | SLK | Homo sapiens | 78.0 |
| Snk(h) | PLK2 | Homo sapiens | 100.0 |
| SNRK(h) | SNRK | Homo sapiens | 103.0 |
| SRMS(h) | SRMS | Homo sapiens | 88.0 |
| SRPK1(h) | SRPK1 | Homo sapiens | 104.0 |
| SRPK2(h) | SRPK2 | Homo sapiens | 102.0 |
| STK16(h) | STK16 | Homo sapiens | 103.0 |
| STK25(h) | STK25 | Homo sapiens | 94.0 |
| STK32A(h) | STK32A | Homo sapiens | 91.0 |
| STK32B(h) | STK32B | Homo sapiens | 104.0 |
| STK32C(h) | STK32C | Homo sapiens | 93.0 |
| STK33(h) | STK33 | Homo sapiens | 99.0 |
| STK39(h) | STK39 | Homo sapiens | 99.0 |
| Syk(h) | SYK | Homo sapiens | 121.0 |
| TAF1L(h) | TAF1L | Homo sapiens | 98.0 |
| TAK1(h) | MAP3K7 | Homo sapiens | 94.0 |
| TAO1(h) | TAOK1 | Homo sapiens | 110.0 |
| TAO2(h) | TAOK2 | Homo sapiens | 103.0 |
| TAO3(h) | TAOK3 | Homo sapiens | 114.0 |
| TBK1(h) | TBK1 | Homo sapiens | 108.0 |
| Tec(h) activated | TEC | Homo sapiens | 104.0 |
| TGFBR1(h) | TGFBR1 | Homo sapiens | 90.0 |
| TGFBR2(h) | TGFBR2 | Homo sapiens | 110.0 |
| Tie2 (h) | TEK | Homo sapiens | 78.0 |
| TLK1(h) | TLK1 | Homo sapiens | 85.0 |
| TLK2(h) | TLK2 | Homo sapiens | 91.0 |
| TNIK(h) | TNIK | Homo sapiens | 89.0 |
| TRB2(h) | TRIB2 | Homo sapiens | 85.0 |
| TrkA(h) | NTRK1 | Homo sapiens | 121.0 |
| TrkB(h) | NTRK2 | Homo sapiens | 106.0 |
| TrkC(h) | NTRK3 | Homo sapiens | 85.0 |
| TSSK1(h) | TSSK1B | Homo sapiens | 92.0 |
| TSSK2(h) | TSSK2 | Homo sapiens | 104.0 |
| TSSK3(h) | TSSK3 | Homo sapiens | 105.0 |
| TSSK4(h) | TSSK4 | Homo sapiens | 86.0 |
| TTBK1(h) | TTBK1 | Homo sapiens | 101.0 |
| TTBK2(h) | TTBK2 | Homo sapiens | 109.0 |
| TTK(h) | TTK | Homo sapiens | 98.0 |
| Txk(h) | TXK | Homo sapiens | 72.0 |
| TYK2(h) | TYK2 | Homo sapiens | 109.0 |
| ULK1(h) | ULK1 | Homo sapiens | 109.0 |
| ULK2(h) | ULK2 | Homo sapiens | 113.0 |
| ULK3(h) | ULK3 | Homo sapiens | 96.0 |
| VRK1(h) | VRK1 | Homo sapiens | 103.0 |
| VRK2(h) | VRK2 | Homo sapiens | 92.0 |
| Wee1(h) | WEE1 | Homo sapiens | 105.0 |
| Wee1B(h) | WEE2 | Homo sapiens | 104.0 |
| WNK1(h) | WNK1 | Homo sapiens | 87.0 |
| WNK2(h) | WNK2 | Homo sapiens | 102.0 |
| WNK3(h) | WNK3 | Homo sapiens | 88.0 |
| WNK4(h) | WNK4 | Homo sapiens | 118.0 |
| Yes(h) | YES1 | Homo sapiens | 100.0 |
| ZAK(h) | MAP3K20 | Homo sapiens | 105.0 |
| ZAP-70(h) | ZAP70 | Homo sapiens | 129.0 |
| ZIPK(h) | DAPK3 | Homo sapiens | 108.0 |
JNJ-78911118
The panel was screened with 10 µM compound. Shown are supplemental data from PMID: 40361296.
Conclusion: Clean panel.
| Target protein | HGNC name | Species | % specific binding at 10 µM | Reference compound | Source |
|---|---|---|---|---|---|
| glyine | Rattus sp. | 33.3 | strychnine | Spinal Cord | |
| h5HT1A | HTR1A | Homo sapiens | 5.5 | 8OHDPAT | HEK |
| h5HT1B | HTR1B | Homo sapiens | 1.1 | GR125743 | RBL |
| h5-HT2A | HTR2A | Homo sapiens | 48.7 | DOI | HEK293 |
| h5HT2B | HTR2B | Homo sapiens | 16.8 | IDOI | CHO |
| h5HT2C | HTR2C | Homo sapiens | 44.4 | MES | HEK293 |
| h5HT3 | HTR3A | Homo sapiens | 5.1 | BRL43694 | CHO |
| h5HT5A | HTR5A | Homo sapiens | -16.0 | LSD | HEK293 |
| h5HT6 | HTR6 | Homo sapiens | 6.6 | LSD | CHO |
| h5HT7 | HTR7 | Homo sapiens | 16.9 | LSD | CHO |
| h5HTT | SLC6A4 | Homo sapiens | 11.7 | IMIP | CHO |
| hA1 | ADORA1 | Homo sapiens | 13.0 | DPCPX | CHO |
| hA2A | ADORA2A | Homo sapiens | -4.5 | CGS21680 | HEK293 |
| hA3 | ADORA3 | Homo sapiens | 41.3 | ABMECA | HEK293 |
| hAb1 | ADRB1 | Homo sapiens | 2.7 | CGP12177 | HEK293 |
| hAb2 | ADRB2 | Homo sapiens | -6.1 | CGP12177 | CHO |
| hACHE | ACHE | Homo sapiens | -0.4 | Atch | HEK293 |
| hAR | AR | Homo sapiens | -1.1 | Metrienolone | LNCaP |
| hBK2 | BDKRB2 | Homo sapiens | 11.3 | BK | CHO |
| hCB1 | CNR1 | Homo sapiens | 13.3 | CP 55940 | Chem |
| hCB2 | CNR2 | Homo sapiens | 25.2 | WIN552122 | CHO |
| hCCK2 | CCKBR | Homo sapiens | 7.9 | CCK8 | CHO |
| hCCKA | CCKAR | Homo sapiens | 15.1 | ICCK8 | CHO |
| hCOX1 | PTGS1 | Homo sapiens | 7.6 | baculovirus system | |
| hCOX2 | PTGS2 | Homo sapiens | 1.2 | baculovirus system | |
| hD1 | DRD1 | Homo sapiens | 6.8 | SCH23390 | CHO |
| hD2S | DRD2 | Homo sapiens | 3.4 | OHDPAT | HEK293 |
| hDAT | SLC6A3 | Homo sapiens | 6.5 | BTCP | CHO |
| hEP2 | PTGER2 | Homo sapiens | 30.2 | PGE2 | HEK2923 |
| hEP4 | PTGER4 | Homo sapiens | 5.4 | PGE2 | HEK2923 |
| hETA | EDNRA | Homo sapiens | 7.9 | IET1 | CHO |
| hGR | NR3C1 | Homo sapiens | -7.2 | DEX | IM9 |
| hH1 | HRH1 | Homo sapiens | -0.5 | PYR | HEK293 |
| hH2 | HRH2 | Homo sapiens | 10.2 | IAPT | CHO |
| hIP1 | Homo sapiens | -7.0 | Oloprost | HEK293 | |
| hLck | LCK | Homo sapiens | 3.6 | insect cells | |
| hM1 | CHRM1 | Homo sapiens | 38.9 | PZP | CHO |
| hM2 | CHRM2 | Homo sapiens | 32.2 | AFDX | CHO |
| hM3 | CHRM3 | Homo sapiens | 38.6 | 4DAMP | CHO |
| hM4 | CHRM4 | Homo sapiens | 38.1 | 4DAMP | CHO |
| hM5 | CHRM5 | Homo sapiens | 14.7 | 4DAMP | CHO |
| hMAO | MAOA | Homo sapiens | 6.2 | A | placenta |
| hMT1 | MTNR1A | Homo sapiens | 56.1 | IML | CHO |
| hN muscle-typealpha | Homo sapiens | 14.4 | bungarotoxin | TE671 | |
| hNET | SLC6A2 | Homo sapiens | 2.5 | NIS | CHO |
| hNK1 | TACR1 | Homo sapiens | 15.1 | SP | U373MG |
| hNK2 | TACR2 | Homo sapiens | 14.7 | INKA | CHO |
| hNK3 | TACR3 | Homo sapiens | 16.7 | SR142801 | CHO |
| hNneuronala4b2 | Homo sapiens | 3.2 | CYS | SHSY5Y | |
| hNT1 | NTSR1 | Homo sapiens | 1.3 | NT | CHO |
| hOP1 | OPRD1 | Homo sapiens | 13.3 | Dadle | CHO |
| hOP2 | OPRK1 | Homo sapiens | 35.6 | U69593 | RBL |
| hOP3 | OPRM1 | Homo sapiens | 23.9 | DAMGO | HEK293 |
| hPDE3A | PDE3A | Homo sapiens | -6.9 | Sf9 cells | |
| hPDE4D2 | PDE4D | Homo sapiens | -0.8 | Sf9 cells | |
| hPR | PGR | Homo sapiens | 0.0 | progesterone | T47D |
| hSigma | Homo sapiens | 9.2 | Jurkat | ||
| hTSPO | TSPO | Homo sapiens | 33.1 | PK 11195 | U-118 MG |
| hV1a | AVPR1A | Homo sapiens | -2.5 | AVP | CHO |
| mSST | Mus musculus | -4.8 | ISST | AtT20 | |
| PPAR1C | PPARG | Homo sapiens | -1.4 | ROS | Ecoli |
| rAa1 | ADRA1A | Rattus sp. | -11.0 | PRA | CX |
| rAa2 | ADRA2A | Rattus sp. | -2.3 | RX821002 | CX |
| rBZD | Rattus sp. | -14.6 | FLUI | CX | |
| rCLCH | Rattus sp. | 12.7 | TBPS | CX | |
| rGABA | Rattus sp. | -12.0 | GABA | CX | |
| rGlutamate (ionotropic) AMPA | Rattus sp. | -1.5 | AMPA | Cortex | |
| rGlutamate (ionotropic) Kainic acid | Rattus sp. | 14.9 | kainic acid | Cortex | |
| rGlutamate (ionotropic) MDL | Rattus sp. | 38.2 | MDL | Brain | |
| rK-ATP potassium channel | Rattus sp. | -4.8 | kainic acid | Brain | |
| rKCH | Rattus sp. | -4.6 | IaDEN | CX | |
| rNeuropeptide YY | Rattus sp. | -2.7 | Brain | ||
| rNMDA | Rattus sp. | 40.0 | CGP39653 | CX | |
| rP2X | Rattus sp. | 0.7 | MeATP | Bladder | |
| rPCP | Rattus sp. | 8.0 | TCP | CX | |
| rSKCaCH | Rattus sp. | 0.5 | IAPA | CX | |
| rSLC6/GABA | Rattus sp. | -5.2 | GABA | brain |