In cells

Use at a concentration up to 10 µM.

We recommend to use the PAM GRIN2A probe TP-050 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat: Doses of 100 mpk PO and 60 mpk SC give up to 80% receptor occupancy (RO) in rat with > 70% RO maintained for 1 hour; oral bioavailability in rat; brain penetrant.