In cells

Use at a concentration up to 30 µM.

We recommend to use the NAM GRIN2A probe JNJ-78911118 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rats with oral (10 mg/kg) and intravenous (1 mg/kg) administration. Shows good oral bioavailability, blood–brain barrier permeability and significant neuroplastic enhancement in the rat hippocampus 24 h after oral administration. Recommended in vivo dose is 30 mg/kg or less.