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SAFit2

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
5-HT1A	HTR1A	-0.30
5-HT1B	HTR1B	0.60
5-HT1D	HTR1D	15.50
5-HT1E	HTR1E	-13.90
5-HT2A	HTR2A	21.90
5-HT2B	HTR2B	8.50
5-HT2C	HTR2C	56.10	> 10000.00
5-HT3	HTR3A	7.60
5-HT5A	HTR5A	25.90
5-HT6	HTR6	9.50
5-HT7A	HTR7	3.00
Alpha1A	ADRA1A	6.70
Alpha1B	ADRA1B	-1.10
Alpha1D	ADRA1D	-11.60
Alpha2A	ADRA2A	23.80
Alpha2B	ADRA2B	7.60
Alpha2C	ADRA2C	49.70
Beta1	ADRB1	-6.50
Beta2	ADRB2	14.50
Beta3	ADRB3	37.10
GABAA/BZP		-9.90
D1	DRD1	24.30
D2	DRD2	50.00	> 10000.00
D3	DRD3	39.70
D4	DRD4	8.10
D5	DRD5	9.20
DAT	SLC6A3	41.00
DOR	OPRD1	13.40
GABAA		17.20
H1	HRH1	37.90
H2	HRH2	30.30
H3	HRH3	12.90
H4	HRH4	71.80	3382.00
KOR	OPRK1	5.90
M1	CHRM1	7.50
M2	CHRM2	7.00
M3	CHRM3	0.40
M4	CHRM4	3.40
M5	CHRM5	20.50
MOR	OPRM1	20.90
NET	SLC6A2	36.90
GABA/PBR		3.10
SERT	SLC6A4	9.50
Sigma 1	SIGMAR1	49.40
Sigma 2	TMEM97	84.90	226.00

ddSAFit2

Compound concentration: 10 µM

Receptor	HGNC target name	Inhibition [%] (Primary experimental value)	Ki [nM] (Secondary experimental value)	pKi
H2	HRH2	50.69	2960.61	5.57
Beta3	ADRB3	35.13
5-HT1B	HTR1B	30.25
5-HT1D	HTR1D	57.05	3130.83 average (n=2)	5.51
5-HT1A	HTR1A	12.19
5-HT1E	HTR1E	12.55
5-HT2A	HTR2A	4.40
5-HT2B	HTR2B	19.40
5-HT2C	HTR2C	-14.49
5-HT3	HTR3A	0.13
5-HT5A	HTR5A	6.87
5-HT6	HTR6	-13.70
5-HT7A	HTR7	-3.87
Alpha1A	ADRA1A	-28.53
Alpha1B	ADRA1B	-5.80
Alpha1D	ADRA1D	-14.48
Alpha2A	ADRA2A	26.62
Alpha2B	ADRA2B	19.68
Alpha2C	ADRA2C	25.16
Beta1	ADRB1	-0.58
Beta2	ADRB2	-10.43
GABAA/BZP		20.56
D1	DRD1	19.05
D2	DRD2	14.68
D3	DRD3	28.12
D4	DRD4	9.71
D5	DRD5	4.07
DAT	SLC6A3	68.41	2175.70	5.66
DOR	OPRD1	4.39
H1	HRH1	14.22
H3	HRH3	10.16
H4	HRH4	49.48
KOR	OPRK1	5.75
M1	CHRM1	4.82
M2	CHRM2	-18.58
M3	CHRM3	-3.44
M4	CHRM4	17.96
M5	CHRM5	-1.68
MOR	OPRM1	4.34
NET	SLC6A2	52.40	> 10000.00	< 5.00
GABA/PBR		-25.27
SERT	SLC6A4	-5.10
Sigma 1	SIGMAR1	58.09	2852.33	5.54
Sigma 2	TMEM97	98.40	409.35	6.39

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