Physicochemical properties of probe BAY-069 and control BAY-771
| BAY-069 | |
|---|---|
| TPSA | 59 Å2 |
| log D (pH 7.5) | 2.4 |
| pka | 5.7 |
| Ligand-lipophilicity efficiency (LLE) | 4.8 |
| Binding efficiency index (BEI) | 19.4 |
| BAY-771 | |
|---|---|
| TPSA | 59 Å2 |
| log D (pH 7.5) | 2.2 |
Solubility
| BAY-069: |
Water pH 6.5: < 0.1 mg/L,
PBS pH 6.5: 93 mg/L,
Citrate buffer pH 4: 4.4 mg/L,
PEG400/EtOH/H2O 60/10/30: > 830 mg/L,
PEG400/H2O 60/40: > 790 mg/L
|
| BAY-771: |
Water pH 6.5: < 412 mg/L
|