Physicochemical properties of probe BAY-439 and control BAY-163
| BAY-439 | |
|---|---|
| TPSA | 80.5 Å2 |
| log D (pH 7.5) | 2.3 |
| Binding efficiency index (BEI) | 22.5 |
| Ligand-lipophilicity efficiency (LLE) | 5.9 |
| BAY-163 | |
|---|---|
| TPSA | 57.7 Å2 |
| log D (pH 7.5) | 3.1 |
Solubility
| BAY-439: |
Aqueous pH 6.5: 15 mg/L,
Aqueous pH 4: > 865 mg/L,
FaSSIF: 35 mg/L,
FeSSIF: 464 mg/L
|
| BAY-163: |
Aqueous pH 6.5: 11 mg/L,
Aqueous pH 4: > 500 mg/L
|