Physicochemical properties of probe BAY-784 and control BAY-786
| BAY-784 | |
|---|---|
| c log D (pH 7.5) | 3.6 |
| log D (pH 7.5) | 4.1 |
| Ligand-lipophilicity efficiency (LLE) | 4.0 |
| BAY-786 | |
|---|---|
| TPSA | 114 Å2 |
| Calculated log D (pH 7.5) | 2.5 |
Solubility
| BAY-784: |
Aqueous pH 7: 1µg/mL,
EtOH: 9 mg/mL,
Aqueous pH 6.5: 7.1 mg/mL
|
| BAY-786: |
pH 6.5 sol. from DMSO: < 0.1 mg/L
|