Physicochemical properties of probe BI-3812 and control BI-5273
| BI-3812 | |
|---|---|
| Lipophilic ligand efficiency.(LLE) (calc., based on ULight IC50) | ≥ 7.9 |
| Ligand efficiency (LE) (calc., based on ULight IC50) | ≥ 0.30 kcal/mol |
| BI-5273 | |
|---|---|
| log P | 84.0 |
Solubility
| BI-3812: |
Aqueous pH 6.8: < 1 µg/mL,
FeSSiF pH 5.5 (Fed State Simulated Intestinal Fluid): 107 µg/mL,
FaSSiF pH 6.5 (Fated State Simulated Intestinal Fluid): 110 µg/mL
|
| BI-5273: |
Aqueous pH 6.8: 22 µg/mL,
Aqueous pH 6.8: 22 µg/mL
|