Physicochemical properties of probe GNE-2256 and control GNE-6689
| GNE-2256 | |
|---|---|
| TPSA | 112 Å2 |
| log D (pH 7.5) | 2.0 |
| Ligand-lipophilicity efficiency (LLE) (calc.) | 8.4 |
| cLog P | 0.5 |
| GNE-6689 | |
|---|---|
| log D (pH 7.5) | 0.4 |
Solubility
| GNE-2256: |
Kinetic solubility: 24 µM
|
| GNE-6689: |
Kinetic solubility: 200 µM
|