Physicochemical properties of probe JNJ-3738 and control JNJ-6240
| JNJ-3738 | |
|---|---|
| TPSA | 116 Å2 |
| measured log D (pH 7.4) | 1.8 |
| clogP | 2.8 |
| pKa1 | 6.1 |
| pKa2 | 2.6 |
| JNJ-6240 | |
|---|---|
| clogP | 2.1 |
Solubility
| JNJ-3738: |
Aqueous pH 7: 15 µM,
Aqueous pH 2: > 500 µM,
FASSIF: 340 µM,
FESSIF: 397 µM
|
| JNJ-6240: |
Aqueous pH 7: 8.3 µM,
Aqueous pH 2: 399 µM
|