In cells

Use at concentration up to 1 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mouse (IV 0.5 mpk (20% HPCD), PO 5 mpk (20% HPCD)), rat (IV 1 mpk (20% HPCD), PO 5 mpk (20% HPCD)) and dog (IV 1 mpk (20% HPCD), PO 5 mpk (20% HPCD)); leads to tumor growth inhibition in AML xenograft (Kasumi-1) at 10 mpk QD