Physicochemical properties of probe PF-04418948 and control PF-04475866
| PF-04418948 | |
|---|---|
| Melting point | 174 °C |
| pKa | Acidic - 3.47 |
| log D (pH 7.4) | 1.2 |
| TPSA | 76.1 |
| cLogP | 3.1 |
| PF-04475866 | |
|---|---|
| pKa's | Acidic - 3.47 |
| log D (pH 7.4) | 0.6 |
| TPSA | 66.8 |
| cLogP | 3.9 |
Solubility
| PF-04418948: |
aqeuous, pH 6.5: 330 µM
|
| PF-04475866: |
pH 6.5 : 255 µM
|