Physicochemical properties of probe PF-04554878 and control PF-00911705
| PF-04554878 | |
|---|---|
| Melting point | 240-255°C |
| pKa's | basic pKa = 3.88 |
| log D (pH 7.4) | 2.3 |
| TPSA | 142.1 |
| cLogP | 1.6 |
| PF-00911705 | |
|---|---|
| pKa's | basic 3.88 |
| log D (pH 7.4) | 2.5 |
| TPSA | 142.1 |
| cLogP | 1.8 |
Solubility
| PF-04554878: |
aqeuous, pH 6.5: 3.7 µM
|
| PF-00911705: |
pH 6.5 : 14.4 µM
|