In cells

Use at concentration < 10 nM. Covers IC₅₀ to IC₉₀ range and maintains selectivity vs other MMPs.

Note: Control compound may contain tiny amounts of active enantiomer. In this case MMP12 IC₅₀ = 80 nM was observed.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mice with 5 mg/kg orally or 0.3 mg/kg (i.v.).