In cells

Use at concentration < 1 nM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat with 1.2 mg/kg (iv) and 3 mg/kg (po); shows a dose dependent effect on mean arterial blood pressure in Dahl salt sensitive rats.