In cells

Use at concentrations up to 100 nM. Note: BI 207127 is light-sensitive in diluted solutions!

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

The interferon-free combination of our NS3 protease inhibitor faldaprevir with BI 207127 and ribavirin has demonstrated high efficacy and good tolerability in GT1b treatment-naive patients in phase II clinical trials.