In cells

Use at concentrations up to 100 nM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

BI-2540 shows low clearance and good bioavailability upon p.o. dosing in rats. Tested: i.v. 2 mg/kg, p.o. 10 mg/kg