In cells

Use at concentration up to 2 µM.

Note: There is a dual inhibitor of AAK1 and BMP2K/BIKE available from SGC, SGC-AAK1-1, that, in addition, could be used as control.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in rat (IV 1 mg/kg and PO 10 mg/kg ) and mouse (PO 30 mg/kg)