In cells

Use at concentration up to 1 µM

We recommend to use the SMARCA2/4, PB1(5) bromodomains of BAF/PBAF probe SGC-SMARCA-BRDVIII also available from SGC for control experiments. Use within recommended dosage limits.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in vivo in 6-7 week old, female nude mice dosed daily with up to 20 mg/kg FHT-2344 by oral gavage; Promotes uveal melanoma tumor regression in 92-1 UM cells.