Usage recommendations for probe MSD-CYP11B2 and control MSD-CYP11B2 Negative control
In cells
Recommended dosing is up to IC90 ~ 25-100 nM.
Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.
In vivo
Good pharmacokinetic profile in rat and rhesus. Tested in rhesus model: IV infusions with up to 0.3 mg/kg, but also suitable for oral dosing; produces significant reductions in rhesus plasma aldosterone levels with no apparent effect on cortisol levels.