In cells

Recommended dosing is up to IC₉₀ ~  25-100 nM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Good pharmacokinetic profile in rat and rhesus. Tested in rhesus model: IV infusions with up to 0.3 mg/kg, but also suitable for oral dosing; produces significant reductions in rhesus plasma aldosterone levels with no apparent effect on cortisol levels.