In cells

Use at concentration up to 100 nM. No cytotoxic effects in Hep-G2 cells after 72 h incubation up to 100 µM (CellTiterGlo assay) and in HEK294, MRC9, U2OS cells after 12-48 h at 10 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mice with 3 mg/kg (iv) and 10 mg/kg (po, sc).