In cells

Use between 200 nM and 1 µM.

Use with other available METAP2 inhibitors as proposed in downloadable information.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Inhibitor shows robust efficacy in body weight loss in mouse obesity models. A dose-dependent body weight loss (BWL) was observed when DIO mice were dosed orally for 28 days at 3, 10 and 30 mg/kg qd.