In cells

Use at concentration up to 10 µM.

We recommend to use the OGA inhibitor JNJ-65355394 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mice with 30 mg/kg (oral administration); shows a good pharmacokinetic profile with brain penetration. The in vivo efficacy was not tested.