In cells

Use at concentration up to 10 µM.

We recommend to use the OGA inhibitor TP-040 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

JNJ-65355394 blocks OGA in vivo in mouse brain after single po gavage administration (100 mg/kg).