Potency data for probe BAY-6672 and control BAY-403
In vitro potency
| Target name | Target information | Species | Assay description | BAY-6672 | BAY-403 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| PTGFR | Homo sapiens | Panlabs binding assay | IC50 = 22 nM | IC50 > 10 µM | PMID: 32969660 |
In cell potency
| Target name | Target information | Species | Assay description | Compound conc. | BAY-6672 | BAY-403 | Publication of assay conditions |
|---|---|---|---|---|---|---|---|
| PTGFR | Homo sapiens | Bayer inhouse assay (human) | IC50 = 11 nM ± 3.000 nM (n=2) | IC50 = 1.2 µM | PMID: 32969660 | ||
| PTGFR | Mus musculus | Bayer inhouse assay (mouse) | IC50 = 5 nM | PMID: 32969660 | |||
| PTGFR | Rattus sp. | Bayer inhouse assay (rat) | IC50 = 11 nM | PMID: 32969660 | |||
| Wistar rat tissue | Rattus sp. | Wistar rat tissue assay of PGF2alpha-induced contraction of (nonpregnant) uterus at Panlabs | IC50 = 52 nM | PMID: 32969660 | |||
| Lung fibroblasts (mouse 3T3 cells) | Mus musculus | Functional cellular assay: cytokine-induced neutrophil-attracting chemokine (KC) inhibition: profibrotic PGF2α-induced cytokine production | IC50 = 12 nM | PMID: 32969660 | |||
| Lung fibroblasts (mouse 3T3 cells) | Mus musculus | Functional cellular assay: MCP-1 inhibition: profibrotic PGF2α-induced cytokine production | IC50 = 18 nM | PMID: 32969660 | |||
| TBXA2R | HEK293 cells | Homo sapiens | Eurofins-Panlabs cell assay (ID:338490): https://www.eurofinsdiscoveryservices.com/catalogmanagement/viewitem/TP-TXA2-Human-Prostanoid-GPCR-Cell-Based-Agonist-Antagonist-IP1-Assay-Panlabs/338490 | 10 µM | IC50 = 2.21 µM |