In cells

Use at a concentration up to 500 nM.

Note: BAY-6672 is sythesized as a hydrochloride hydrate. The structure and MW provided here refer to the saltless structure.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

In vivo efficacy in a pulmonary fibrosis model (10 days silica-induced fibrosis) in mice, oral (gavage) administration (3 -30 mg/ kg bid): Significant reduction of relevant pro-fibrotic and inflammatory biomarkers.