Potency data for probe BI 639667 and control BI-9307
In vitro potency
| Target name | Target information | Species | Assay description | BI 639667 | BI-9307 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| CCR1 | Homo sapiens | Scintillation Proximity Assay binding: CCR1 binding affinity | IC50 = 5.4 nM |
In cell potency
| Target name | Target information | Species | Assay description | BI 639667 | BI-9307 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| CCR1 | Homo sapiens | Ca flux: CCR1 molecular potency | IC50 = 24 nM | IC50 > 3000 nM | ||
| CCR1 | Homo sapiens | Chemotaxis: CCR1 cellular potency | IC50 = 2.4 nM | |||
| CCR1 | Homo sapiens | Receptor internalization: Whole blood potency | IC50 = 9 nM |