In cells

Use at concentration of 0.1 μM.

We recommend to use the CCR1 antagonist probe BAY-3153 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Due to reduced rodent potency this compound was not tested in in vivo disease models. However, efficacy in models such as collagen induced arthritis (CIA) in mouse has been demonstrated with cross-reactive tool compound in house. For rats: Vss [L/kg] = 1.1, MRT [h] = 1.9, CL [%QH] = 13, F = 10%