Potency data for probe BIBO3304 and control BIBO3457
No in vitro potency data available.
In cell potency
| Target name | Target information | Species | Assay description | BIBO3304 | BIBO3457 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| NPY1R | human NPY1R stably expressed in baby hamster kidney (BHK) cells | Homo sapiens | Radioligand binding assay (NPY1R, BHK) | IC50 = 0.69 nM ± 0.160 nM | IC50 > 10 µM | PMID: 9806339 |
| NPY1R | endogenous from SK-N-MC cells | Homo sapiens | Radioligand binding assay (NPY1R, SK-N-MC) | IC50 = 0.38 nM ± 0.060 nM | IC50 = 1.3 µM ± 0.070 µM | PMID: 9806339 |
| NPY1R | rat NPY1R expressed inHEK93 cells | Rattus norvegicus | Radioligand binding assay (NPY1R, HEK293, rat) | IC50 = 0.72 nM ± 0.420 nM | IC50 > 1 µM | PMID: 9806339 |
| NPY2R | human expressed in SMS-KAN cells | Homo sapiens | Radioligand binding assay (NPY2R, SMS-KAN cells) | IC50 > 10 µM | IC50 > 10 µM | PMID: 9806339 |
| NPY2R | human expressed in BHK cells | Homo sapiens | Radioligand binding assay (NPY2R, BHK) | IC50 > 1 µM | IC50 > 10 µM | PMID: 9806339 |
| NPY2R | rat hippocampus | Rattus norvegicus | Radioligand binding assay (NPY2R, rat hippocampus) | IC50 > 10 µM | PMID: 9806339 | |
| NPY4R | human expressed in CHO cells | Homo sapiens | Radioligand binding assay (human NPY4R, CHO cells) | IC50 = 12.3 µM ± 5.000 µM | IC50 = 24 µM ± 6.500 µM | PMID: 9806339 |
| NPY4R | rat expressed in CHO cells | Rattus norvegicus | Radioligand binding assay (rat NPY4R, CHO cells) | IC50 > 10 µM | IC50 > 10 µM | PMID: 9806339 |
| NPY5R | human expressed in HEK293 cells | Homo sapiens | Radioligand binding assay (human NPY5R, HEK293) | IC50 > 10 µM | IC50 = 28 µM ± 4.000 µM | PMID: 9806339 |
| NPY5R | rat expressed in CHO cells | Rattus norvegicus | Radioligand binding assay (rat NPY5R, CHO cells) | IC50 = 21 µM ± 4.500 µM | IC50 = 23 µM ± 2.000 µM | PMID: 9806339 |