Selectivity data for probe BIBO3304 and control BIBO3457
Coming soon
BIBO3304
Conclusion: Closest off-targets are OPRK1 (30 % ctrl).
| Target protein | HGNC name | Species | Cmp. conc. | % Control | Assay ID |
|---|---|---|---|---|---|
| 5HT1B(H) | HTR1B | Homo sapiens | 10 µM | 60.0 | Cerep_4376 |
| CB1(HU)_AGON | CNR1 | Homo sapiens | 10 µM | 107.0 | Cerep_4708 |
| COX-1 | PTGS1 | Homo sapiens | 10 µM | 81.0 | Cerep_4173 |
| COX-2 | PTGS2 | Homo sapiens | 10 µM | 61.0 | Cerep_4186 |
| KAPPA(KOP)_HU | OPRK1 | Homo sapiens | 10 µM | 30.0 | Cerep_4461 |
| 5HT1A/H | HTR1A | Homo sapiens | 10 µM | 56.0 | Cerep_131 |
| 5HT2AH_AGON | HTR2A | Homo sapiens | 10 µM | 60.0 | Cerep_471 |
| 5HT2B/H AG | HTR2B | Homo sapiens | 10 µM | 57.0 | Cerep_1333 |
| 5HT3/H | HTR3A | Homo sapiens | 10 µM | 91.0 | Cerep_411 |
| A2A/H | ADORA2A | Homo sapiens | 10 µM | 107.0 | Cerep_4 |
| ACE(HU_AMTCH400) | ACE | Homo sapiens | 10 µM | 103.0 | Cerep_3441 |
| ALPHA1AH_ANTAG | ADRA1A | Homo sapiens | 10 µM | 102.0 | Cerep_2338 |
| ALPHA2A/HU | ADRA2A | Homo sapiens | 10 µM | 93.0 | Cerep_13 |
| ANDROGEN/H | AR | Homo sapiens | 10 µM | 91.0 | Cerep_933 |
| BETA1/HUM | ADRB1 | Homo sapiens | 10 µM | 106.0 | Cerep_18 |
| BETA2/HUM | ADRB2 | Homo sapiens | 10 µM | 108.0 | Cerep_20 |
| BZD/CENTR/R | Rattus norvegicus | 10 µM | 83.0 | Cerep_28 | |
| CA+/DHPSI/R | Rattus norvegicus | 10 µM | 70.0 | Cerep_161 | |
| CB2/PERIPH/H | CNR2 | Homo sapiens | 10 µM | 91.0 | Cerep_37 |
| CCKA/H | CCKAR | Homo sapiens | 10 µM | 66.0 | Cerep_39 |
| D1/H | DRD1 | Homo sapiens | 10 µM | 97.0 | Cerep_44 |
| D2SH_AGON | DRD2 | Homo sapiens | 10 µM | 40.0 | Cerep_1322 |
| DATRANS/HUM | SLC6A3 | Homo sapiens | 10 µM | 79.0 | Cerep_52 |
| DELTA2/H | OPRD1 | Homo sapiens | 10 µM | 80.0 | Cerep_114 |
| ETA/H | EDNRA | Homo sapiens | 10 µM | 112.0 | Cerep_54 |
| GCORTICOID/H | NR3C1 | Homo sapiens | 10 µM | 98.0 | Cerep_469 |
| H1/PYRIL/HS | HRH1 | Homo sapiens | 10 µM | 75.0 | Cerep_870 |
| H2/APT/HS | HRH2 | Homo sapiens | 10 µM | 117.0 | Cerep_1208 |
| HERG_DOFETILIDE | KCNH2 | Homo sapiens | 10 µM | 79.0 | Cerep_4094 |
| K+/VOLT/RA | Rattus norvegicus | 10 µM | 100.0 | Cerep_166 | |
| LCK_CE | LCK | Homo sapiens | 10 µM | 86.0 | Old_Cerep_2906 |
| M1/H | CHRM1 | Homo sapiens | 10 µM | 89.0 | Cerep_91 |
| M2/H | CHRM2 | Homo sapiens | 10 µM | 90.0 | Cerep_93 |
| M3/H | CHRM3 | Homo sapiens | 10 µM | 87.0 | Cerep_95 |
| MAO-A_ANTAG | MAOA | Rattus norvegicus | 10 µM | 97.0 | Cerep_443 |
| MU/H | OPRM1 | Homo sapiens | 10 µM | 71.0 | Cerep_118 |
| NA+/SITE2/R | Rattus norvegicus | 10 µM | 94.0 | Old_Cerep_169 | |
| NEUP/H | SLC6A2 | Homo sapiens | 10 µM | 91.0 | Cerep_355 |
| NMDA/R | Rattus norvegicus | 10 µM | 109.0 | Cerep_66 | |
| N_NEURO_A4B2 |
CHRNA4 CHRNB2 |
Homo sapiens | 10 µM | 110.0 | Cerep_3029 |
| PDE3A | PDE3A | Homo sapiens | 10 µM | 84.0 | Cerep_4072 |
| PDE4D2 | PDE4D | Homo sapiens | 10 µM | 91.0 | Cerep_4077 |
| SLC6A4/H | SCL6A4 | Homo sapiens | 10 µM | 84.0 | Cerep_439 |
| V1A/HUM | AVPR1A | Homo sapiens | 10 µM | 29.0 | Cerep_159 |
BIBO3304
Conclusion: Clean panel.
| Target protein | HGNC name | Species | % control at 10 µM | % control at 30 µM | % control at 1000 µM | % control at 100 µM | Mode of action | Assay |
|---|---|---|---|---|---|---|---|---|
| 15LO | ALOX15 | Oryctolagus cuniculus | 118.00 | inhibitor | absorption of electromagnetic radiation | |||
| 5HT1/R |
HTR1A HTR1B HTR1D |
Rattus norvegicus | 90.0 | Radioactive Assay | ||||
| 5HT1A/R | HTR1A | Rattus norvegicus | 81.0 | Radioactive Assay | ||||
| 5HT2/R |
HTR2A HTR2C HTR2B |
Rattus norvegicus | 92.0 | Radioactive Assay | ||||
| 5HT3/RB | HTR3A | Oryctolagus cuniculus | 99.0 | Radioactive Assay | ||||
| 5LO | ALOX5 | 97.00 | Radioactive Assay | |||||
| A1/R | ADORA1 | Rattus norvegicus | 99.0 | Radioactive Assay | ||||
| A2A/R | ADORA2A | Rattus norvegicus | 97.0 | Radioactive Assay | ||||
| ACOASYN | ACSS2 | 100.00 | inhibitor | Radioactive Assay | ||||
| ALPHA1/R | ADRA1D | Rattus norvegicus | 91.0 | Others | ||||
| ALPHA1A/R | ADRA1A | Rattus norvegicus | 98.0 | Others | ||||
| ALPHA1B/R | ADRA1B | Rattus norvegicus | 114.0 | Radioactive Assay | ||||
| ALPHA2/R |
ADRA2A ADRA2B ADRA2C |
Rattus norvegicus | 96.0 | Others | ||||
| ALPHA2A/RB | ADRA2A | Oryctolagus cuniculus | 82.0 | Radioactive Assay | ||||
| ALPHA2B/R | ADRA2B | Rattus norvegicus | 91.0 | |||||
| AMPA/RA | GRIA1 | Rattus norvegicus | 96.0 | |||||
| ANF/GP | NPR1 | Cavia porcellus | 97.0 | Radioactive Assay | ||||
| ATII/RB | AGTR2 | Oryctolagus cuniculus | 99.0 | Radioactive Assay | ||||
| B2/GP | BDKRB2 | Cavia porcellus | 115.0 | Radioactive Assay | ||||
| BETA/R | Rattus norvegicus | 106.0 | Radioactive Assay | |||||
| BETA1/RB | ADRB1 | Oryctolagus cuniculus | 82.0 | Radioactive Assay | ||||
| BETA2/R | ADRB2 | Rattus norvegicus | 77.0 | Radioactive Assay | ||||
| BOMBESIN/R | BRS3 | Rattus norvegicus | 100.0 | Radioactive Assay | ||||
| CA+/DHPSI/RA | CACNA1C | Rattus norvegicus | 82.0 | Radioactive Assay | ||||
| CA+/N/RA | CACNA1B | Rattus norvegicus | 110.0 | Radioactive Assay | ||||
| CALCINEUPP2B | PPP3CB | Rattus norvegicus | 90.0 | inhibitor | Radioactive Assay | |||
| CALPAIN | CAPN1 | Homo sapiens | 108.0 | inhibitor | FI - fluorescence intensity | |||
| CANHYDRASE | CA6 | Homo sapiens | 96.0 | inhibitor | absorption of electromagnetic radiation | |||
| CCKA/R | CCKAR | Rattus norvegicus | 87.0 | Radioactive Assay | ||||
| CCKB/M | CCKBR | Mus musculus | 117.0 | |||||
| CGRP/R | CALCRL | Rattus norvegicus | 92.0 | Radioactive Assay | ||||
| CNOS | NOS3 | Rattus norvegicus | 104.0 | inhibitor | Radioactive Assay | |||
| D1/HU | DRD1 | Homo sapiens | 95.0 | Radioactive Assay | ||||
| D1/R | DRD1 | Rattus norvegicus | 103.0 | Radioactive Assay | ||||
| D2/RAC/R | DRD2 | Rattus norvegicus | 84.0 | |||||
| D2HSPIP | DRD2 | Homo sapiens | 97.0 | |||||
| D3/HU | DRD3 | Homo sapiens | 98.0 | Not applicable | Scintillation counting | |||
| D5/HU | DRD5 | Homo sapiens | 94.0 | Radioactive Assay | ||||
| DELTA/GP | OPRD1 | Cavia porcellus | 80.0 | Radioactive Assay | ||||
| EGF/HU | EGFR | Homo sapiens | 94.0 | Radioactive Assay | ||||
| EGFRTYRKIN | EGFR | Homo sapiens | 83.0 | inhibitor | Fluorimetry | |||
| ELASTASEPMN | ELANE | Homo sapiens | 94.00 | absorption of electromagnetic radiation | ||||
| ESTROGEN/BO | ESR1 | 85.0 | Radioactive Assay | |||||
| ETA/R | EDNRA | Rattus norvegicus | 88.0 | Radioactive Assay | ||||
| ETB/R | EDNRB | Rattus norvegicus | 98.0 | Radioactive Assay | ||||
| GABAA-AGSI/R | GABRA1 | Rattus norvegicus | 104.0 | agonist | Scintillation counting | |||
| GABAACENTR | GABRA1 | Rattus norvegicus | 89.0 | Radioactive Assay | ||||
| GABAACL+ | GABRA1 | Rattus norvegicus | 84.0 | Radioactive Assay | ||||
| GALANIN/R | GALR1 | Rattus norvegicus | 91.0 | Radioactive Assay | ||||
| GCORTIC/H | NR3C1 | Homo sapiens | 86.0 | Radioactive Assay | ||||
| GLUTAMAT/R | GRM1 | Rattus norvegicus | 95.0 | Radioactive Assay | ||||
| GLYCINSTRS | GLRA1 | 81.0 | Radioactive Assay | |||||
| H1/CENT/GP | HRH1 | Cavia porcellus | 102.0 | Radioactive Assay | ||||
| H3/R | HRH3 | Rattus norvegicus | 104.0 | fluorescence resonance energy transfer | ||||
| HMGCOARED | HMGCR | Rattus norvegicus | 98.00 | inhibitor | Radioactive Assay | |||
| IL-1ALPHA/M | IL1R1 | Mus musculus | 88.0 | Radioactive Assay | ||||
| IL-6/H | IL6R | Homo sapiens | 87.0 | SPA - blue shifted | ||||
| IL-8/H | CXCR2 | Homo sapiens | 100.0 | Radioactive Assay | ||||
| INOS | NOS2 | Mus musculus | 99.0 | absorption of electromagnetic radiation | ||||
| INSULIN/R | INSR | Rattus norvegicus | 98.0 | Radioactive Assay | ||||
| K+/KA/R | KCNA1 | Rattus norvegicus | 99.0 | Radioactive Assay | ||||
| K+/KATP/HA | KCNJ1 | Mullus auratus | 76.0 | Radioactive Assay | ||||
| K+/KV/R | KCNV1 | Rattus norvegicus | 89.0 | Radioactive Assay | ||||
| K+/SKCA | KCNN1 | Rattus norvegicus | 119.0 | Radioactive Assay | ||||
| KAINATE/R | GRIK1 | Rattus norvegicus | 103.0 | Radioactive Assay | ||||
| KAPPA/GP | OPRK1 | Cavia porcellus | 105.0 | Radioactive Assay | ||||
| LTA4HYD | LTA4H | Cavia porcellus | 102.00 | inhibitor | Radioactive Assay | |||
| LTB4GP | LTB4R | Cavia porcellus | 86.0 | Radioactive Assay | ||||
| LTC4SYN | LTC4S | Cavia porcellus | 97.00 | inhibitor | Radioactive Assay | |||
| LTD4/GP | CYSLTR1 | Cavia porcellus | 109.0 | Radioactive Assay | ||||
| M1/R | CHRM1 | Rattus norvegicus | 73.0 | Radioactive Assay | ||||
| M2/R | CHRM2 | Rattus norvegicus | 98.0 | Radioactive Assay | ||||
| M3/R | CHRM3 | Rattus norvegicus | 85.0 | Radioactive Assay | ||||
| M4/RB | CHRM4 | Oryctolagus cuniculus | 110.0 | Radioactive Assay | ||||
| MU/GP | OPRM1 | Cavia porcellus | 104.0 | Radioactive Assay | ||||
| MUSCARIN/NS | 87.0 | Radioactive Assay | ||||||
| NA+/SITE2/RA | SCN1B | Rattus norvegicus | 102.0 | Radioactive Assay | ||||
| NACH/CENT/R | CHRNB2 | Rattus norvegicus | 98.0 | Radioactive Assay | ||||
| NEUTRALENDOP | MME | Homo sapiens | 102.0 | absorption of electromagnetic radiation | ||||
| NK1/GP | TACR1 | Cavia porcellus | 106.0 | Radioactive Assay | ||||
| NMDAAGSI/R | Rattus norvegicus | 89.0 | agonist | Radioactive Assay | ||||
| NMDAGLSI/R | GRIN1 | Rattus norvegicus | 87.0 | Radioactive Assay | ||||
| NMDAPHSI/R | GRIN2A | Rattus norvegicus | 77.0 | Radioactive Assay | ||||
| OPIAT/NS | 114.0 | Radioactive Assay | ||||||
| P56TYRKINLCK | LCK | Homo sapiens | 97.0 | inhibitor | FI - fluorescence intensity | |||
| P59TYRKINFYN | FYN | Homo sapiens | 84.0 | inhibitor | FI - fluorescence intensity | |||
| PAF/RB | PTAFR | Oryctolagus cuniculus | 91.0 | Radioactive Assay | ||||
| PHORBOLE/M | Mus musculus | 95.0 | inhibitor | Radioactive Assay | ||||
| PKCALPHA | PRKCA | Homo sapiens | 80.0 | inhibitor | Radioactive Assay | |||
| PKCBETA | PRKCB | Homo sapiens | 89.0 | inhibitor | Radioactive Assay | |||
| PKCGAMMA | PRKCG | Homo sapiens | 92.0 | inhibitor | Radioactive Assay | |||
| PROGEST/BO | PGR | Bos taurus | 114.0 | Radioactive Assay | ||||
| SIGMA/NS/GP | Cavia porcellus | 100.0 | Radioactive Assay | |||||
| SIGMA2/GP | TMEM97 | Cavia porcellus | 109.0 | Radioactive Assay | ||||
| SOMATOS/MO | SSTR5 | Mus musculus | 103.0 | Radioactive Assay | ||||
| TESTOST/R | AR | Rattus norvegicus | 88.0 | Radioactive Assay | ||||
| TNFA/HU/HELA | TNF | Homo sapiens | 114.0 | Radioactive Assay | ||||
| TRH/R | TRHR | Rattus norvegicus | 84.0 | Radioactive Assay | ||||
| TXA2/RB | TBXA2R | Oryctolagus cuniculus | 109.0 | Radioactive Assay | ||||
| V1/RA | AVPR1A | Rattus norvegicus | 98.0 | Radioactive Assay | ||||
| VIP1/GP | VIPR1 | Cavia porcellus | 88.0 | Radioactive Assay | ||||
| Y2/RB | NPY2R | Oryctolagus cuniculus | 62.0 | Radioactive Assay |