Potency data for probe MRK-560 and control GSI-NC
In vitro potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| APP | CHAPSO-solubilized SH-SY5Y neuroblastoma P2 cell membranes | Homo sapiens | Radioligand Binding Assay | IC50 = 0.650 nM ± 0.130 nM |
In cell potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| APP | SH-SY5Y (SP4CT) cells | Homo sapiens | Aβ42 inhibition assay | IC50 < 0.500 nM | DOI: 10.1016/j.bmcl.2005.10.009 | |
| APP | SH-SY5Y (SP4CT) cells | Homo sapiens | Aβ40 inhibition assay | IC50 < 0.500 nM | IC50 = 1600 nM | DOI: 10.1016/j.bmcl.2005.10.009 |