In cells

Use 100 nM or less in cell-based experiments.

We recommend to use the gamma secretase complex probe GSM1 also available from SGC for control experiments.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mouse (3 mg/kg (po)), rat, dog and rhesus monkey; shows good oral bioavailability.