Physicochemical properties of probe MRK-560 and control GSI-NC
| MRK-560 | |
|---|---|
| TPSA | 80.3 |
| HPLC logD | 3.8 |
| calc fsp3 | 0.4 |
| calc cLogP ACD V12 | 4.8 |
| GSI-NC | |
|---|---|
| HPLC logD | 4.6 |
Solubility
| MRK-560: |
aqueous, pH 2.0: < 5 µM,
aqueous, pH 7.0: < 5 µM
|
| GSI-NC: |
aqueous, pH 2.0: 128 µM,
aqueous, pH 7.0: 21 µM,
FASSIF pH 6.5: 170 µM
|