Potency data for probe MSC-4381 and control MSC-0516
In vitro potency
| Target name | Target information | Species | Assay description | MSC-4381 | MSC-0516 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| SLC16A3 | Homo sapiens | Fluorescence Cross Correlation Spectroscopy (FCCS) human | Ki = 11 nM (n=3) | PMID: 34382802 | ||
| SLC16A3 | Mus musculus | Fluorescence Cross Correlation Spectroscopy (FCCS) mouse | Ki = 252 nM |
In cell potency
| Target name | Target information | Species | Assay description | MSC-4381 | MSC-0516 | Publication of assay conditions |
|---|---|---|---|---|---|---|
| SLC16A3 | MDA-MB-231 (MCT4+/1-) cells | Homo sapiens | Lactate efflux inhibition assay (MDA-MB-231) | IC50 = 1 nM | IC50 = 506 nM | PMID: 34382802 |
| SLC16A1 | SNU-398 (MCT1+/4-) cells | Homo sapiens | Lactate efflux inhibition assay (SNU-398) | IC50 > 4 µM | IC50 > 4 µM | PMID: 34382802 |
| SLC16A7,SLC16A8 | RT4 (MCT2+/3+) cells | Homo sapiens | Lactate efflux inhibition assay (RT4) | IC50 = 638 nM | IC50 > 4 nM | PMID: 34382802 |
| SLC16A1,SLC16A3 | MiaPaCa2 (MCT1+/4+) cells | Homo sapiens | Lactate efflux inhibition assay (MiaPaCa2 ) | IC50 > 4 µM | IC50 > 4 µM | PMID: 34382802 |