Physicochemical properties of probe MSC-4381 and control MSC-0516
| MSC-4381 | |
|---|---|
| TPSA | 136 Å2 |
| log D (pH 7.5) | 1.5 |
| cLogP | 3.5 |
| pKa | 4.6 |
| MSC-0516 | |
|---|---|
| TPSA | 130 Å2 |
| Melting point | 193 - 196 °C |
| cLogP | 2.8 |
Solubility
| MSC-4381: |
Thermodynamic solubilty PBS (pH 7.4): 58 µg/mL,
Thermodynamic solubilty SGF (pH 1.2): 12 µg/mL,
Thermodynamic solubilty FaSSIF (pH 6.5): 268 µg/mL,
Thermodynamic solubilty FeSSIF (pH 5): 232 µg/mL,
Kinetic solubilty (Ham‘s F-12, 10 % FCS, 1 % DMSO): 25 µM,
Kinetic solubilty (PBS (pH 7.4; 2h)): 121 µM
|
| MSC-0516: |
Thermodynamic solubilty PBS (pH 7.4): 678 µg/mL,
Thermodynamic solubilty SGF (pH 1.2): > 1000 µg/mL,
Thermodynamic solubilty FaSSIF (pH 6.5): 285 µg/mL,
Thermodynamic solubilty FeSSIF (pH 5): 25 µg/mL
|