Potency data for probe NVS-MALT1 and control NVS-MALT1-C
In vitro potency
| Target name | Target information | Species | Assay description | Compound conc. | NVS-MALT1 | NVS-MALT1-C | Publication of assay conditions |
|---|---|---|---|---|---|---|---|
| MALT1 | Homo sapiens | Human biochemical (TR-FRET) assay (low salt) | IC50 = 18 nM | ||||
| MALT1 | Homo sapiens | Human biochemical (TR-FRET) assay (high salt) | IC50 = 2.4 nM | IC50 = 190 nM | |||
| FLT3 | Homo sapiens | Kinase panel | 10 µM | IC50 = 3.5 µM |
In cell potency
| Target name | Target information | Species | Assay description | NVS-MALT1 | NVS-MALT1-C | Publication of assay conditions |
|---|---|---|---|---|---|---|
| MALT1 | Homo sapiens | Jurkat IL-2 (IL2-RGA PMA + anti-CD28) | IC50 = 3.4 nM | IC50 = 1.9 µM | ||
| MALT1 | Homo sapiens | IL-2 – PMA + anti-CD28 + 50% Human whole blood | IC50 = 200 nM | |||
| MALT1 | Rattus sp. | IL-2 – PMA + anti-CD28 + 50% Rat whole blood | IC50 = 130 nM |