Selectivity data for probe NVS-MALT1 and control NVS-MALT1-C


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NVS-MALT1


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT7A HTR7 -18.19
D1 DRD1 23.71
H1 HRH1 10.17
M3 CHRM3 -8.44
M4 CHRM4 21.29
M5 CHRM5 14.61
Sigma 2 TMEM97 49.09
5-HT1B HTR1B 12.52
5-HT2B HTR2B -3.94
5-HT2C HTR2C -4.22
Alpha1A ADRA1A -7.59
Alpha1B ADRA1B 27.59
Alpha1D ADRA1D -6.69
Alpha2B ADRA2B 0.32
D3 DRD3 -4.43
DAT SLC6A3 -17.37
M1 CHRM1 -12.59
M2 CHRM2 -11.58
5-HT1A HTR1A -16.52
5-HT5A HTR5A -13.28
5-HT6 HTR6 -23.54
Alpha2A ADRA2A 14.56
Alpha2C ADRA2C 4.48
D2 DRD2 4.10
GABAA 27.93
H3 HRH3 -5.74
MOR OPRM1 6.13
NET SLC6A2 -28.35
Sigma 1 SIGMAR1 18.78
D4 DRD4 -10.37
D5 DRD5 9.70
DOR OPRD1 -26.40
KOR OPRK1 31.90
GABA/PBR 11.60
5-HT1D HTR1D -2.45
5-HT1E HTR1E -13.05
5-HT2A HTR2A 2.45
5-HT3 HTR3A -6.20
Beta3 ADRB3 15.39
Beta2 ADRB2 26.71
H2 HRH2 -9.88
H4 HRH4 3.84
SERT SLC6A4 11.32
GABAA/BZP 21.34
Beta1 ADRB1 20.62

NVS-MALT1-C


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
GABAA/BZP 20.76
Beta3 ADRB3 12.94
H2 HRH2 5.46
SERT SLC6A4 14.56
5-HT1D HTR1D -3.07
5-HT1E HTR1E -16.72
5-HT2A HTR2A 4.93
5-HT3 HTR3A -1.20
D4 DRD4 -14.05
D5 DRD5 4.72
DOR OPRD1 -31.36
KOR OPRK1 29.45
GABA/PBR 5.14
5-HT1A HTR1A -11.62
5-HT5A HTR5A -23.61
5-HT6 HTR6 -10.22
Alpha2A ADRA2A 5.10
Alpha2C ADRA2C 1.97
D2 DRD2 -4.30
GABAA 19.24
H3 HRH3 -13.90
MOR OPRM1 6.39
NET SLC6A2 -20.65
Sigma 1 SIGMAR1 56.80 1593.68 5.80
5-HT1B HTR1B 11.39
5-HT2B HTR2B 9.74
5-HT2C HTR2C 3.25
Alpha1A ADRA1A -3.44
Alpha1B ADRA1B 5.97
Alpha1D ADRA1D 3.20
Alpha2B ADRA2B 1.55
D3 DRD3 -5.92
M2 CHRM2 -10.51
5-HT7A HTR7 -27.81 > 10000.00 < 5.00
D1 DRD1 17.93
DAT SLC6A3 -18.05
H1 HRH1 -9.88
H4 HRH4 -8.46
M1 CHRM1 -2.39
M3 CHRM3 -2.58
M4 CHRM4 21.05
M5 CHRM5 7.57
Sigma 2 TMEM97 57.12 889.82 6.05

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
View assay details

Jump to control KinomeScan data

NVS-MALT1


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 84.0 1000
ABL1 ABL1-phosphorylated 59.0 1000
ABL2 ABL2 85.0 1000
ACVR1 ACVR1 94.0 1000
ACVR1B ACVR1B 72.0 1000
ACVR2A ACVR2A 93.0 1000
ACVR2B ACVR2B 66.0 1000
ACVRL1 ACVRL1 100.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 77.0 1000
AKT1 AKT1 100.0 1000
AKT2 AKT2 99.0 1000
AKT3 AKT3 100.0 1000
ALK ALK(L1196M) 100.0 1000
PRKAA1 AMPK-alpha1 99.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 100.0 1000
NUAK1 ARK5 98.0 1000
MAP3K5 ASK1 84.0 1000
MAP3K6 ASK2 100.0 1000
AURKA AURKA 100.0 1000
AURKB AURKB 91.0 1000
AURKC AURKC 77.0 1000
AXL AXL 76.0 1000
BMP2K BIKE 89.0 1000
BLK BLK 87.0 1000
BMPR1A BMPR1A 71.0 1000
BMPR1B BMPR1B 100.0 1000
BMPR2 BMPR2 91.0 1000
BMX BMX 99.0 1000
BRAF BRAF(V600E) 96.0 1000
PTK6 BRK 81.0 1000
BRSK1 BRSK1 78.0 1000
BRSK2 BRSK2 79.0 1000
BTK BTK 100.0 1000
BUB1 BUB1 100.0 1000
CAMK1 CAMK1 66.0 1000
PNCK CAMK1B 100.0 1000
CAMK1D CAMK1D 99.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 83.0 1000
CAMK2B CAMK2B 94.0 1000
CAMK2D CAMK2D 86.0 1000
CAMK2G CAMK2G 77.0 1000
CAMK4 CAMK4 100.0 1000
CAMKK1 CAMKK1 80.0 1000
CAMKK2 CAMKK2 80.0 1000
CASK CASK 100.0 1000
CDK11B CDC2L1 88.0 1000
CDK11A CDC2L2 93.0 1000
CDK13 CDC2L5 100.0 1000
CDK19 CDK11 73.0 1000
CDK2 CDK2 88.0 1000
CDK3 CDK3 90.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 96.0 1000
CDK7 CDK7 100.0 1000
CDK8 CDK8 39.0 1000
CDK9 CDK9 85.0 1000
CDKL1 CDKL1 57.0 1000
CDKL2 CDKL2 90.0 1000
CDKL3 CDKL3 73.0 1000
CDKL5 CDKL5 95.0 1000
CHEK1 CHEK1 91.0 1000
CHEK2 CHEK2 90.0 1000
CIT CIT 94.0 1000
CLK1 CLK1 81.0 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 87.0 1000
CLK4 CLK4 94.0 1000
CSF1R CSF1R-autoinhibited 95.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 51.0 1000
CSNK1A1L CSNK1A1L 65.0 1000
CSNK1D CSNK1D 88.0 1000
CSNK1E CSNK1E 66.0 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 93.0 1000
CSNK1G3 CSNK1G3 72.0 1000
CSNK2A1 CSNK2A1 100.0 1000
CSNK2A2 CSNK2A2 100.0 1000
MATK CTK 99.0 1000
DAPK1 DAPK1 88.0 1000
DAPK2 DAPK2 86.0 1000
DAPK3 DAPK3 91.0 1000
DCLK1 DCAMKL1 72.0 1000
DCLK2 DCAMKL2 90.0 1000
DCLK3 DCAMKL3 100.0 1000
DDR1 DDR1 99.0 1000
DDR2 DDR2 100.0 1000
MAP3K12 DLK 100.0 1000
DMPK DMPK 84.0 1000
CDC42BPG DMPK2 87.0 1000
STK17A DRAK1 87.0 1000
STK17B DRAK2 99.0 1000
DYRK1A DYRK1A 75.0 1000
DYRK1B DYRK1B 78.0 1000
DYRK2 DYRK2 89.0 1000
EGFR EGFR(T790M) 90.0 1000
EIF2AK1 EIF2AK1 100.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 97.0 1000
EPHA4 EPHA4 83.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 84.0 1000
EPHA8 EPHA8 91.0 1000
EPHB1 EPHB1 86.0 1000
EPHB2 EPHB2 76.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 100.0 1000
ERBB2 ERBB2 59.0 1000
ERBB3 ERBB3 100.0 1000
ERBB4 ERBB4 84.0 1000
MAPK3 ERK1 100.0 1000
MAPK1 ERK2 100.0 1000
MAPK6 ERK3 92.0 1000
MAPK4 ERK4 94.0 1000
MAPK7 ERK5 92.0 1000
MAPK15 ERK8 87.0 1000
ERN1 ERN1 91.0 1000
PTK2 FAK 85.0 1000
FER FER 88.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 74.0 1000
FGFR2 FGFR2 91.0 1000
FGFR3 FGFR3(G697C) 86.0 1000
FGFR4 FGFR4 85.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 82.0 1000
FLT3 FLT3-autoinhibited 100.0 1000
FLT4 FLT4 89.0 1000
FRK FRK 80.0 1000
FYN FYN 100.0 1000
GAK GAK 98.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 78.0 1000
GRK1 GRK1 82.0 1000
GRK2 GRK2 84.0 1000
GRK3 GRK3 100.0 1000
GRK4 GRK4 85.0 1000
GRK7 GRK7 100.0 1000
GSK3A GSK3A 86.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 100.0 1000
HIPK1 HIPK1 40.0 1000
HIPK2 HIPK2 100.0 1000
HIPK3 HIPK3 100.0 1000
HIPK4 HIPK4 72.0 1000
MAP4K1 HPK1 100.0 1000
HUNK HUNK 100.0 1000
CILK1 ICK 70.0 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 100.0 1000
IKBKB IKK-beta 100.0 1000
IKBKE IKK-epsilon 100.0 1000
INSR INSR 87.0 1000
INSRR INSRR 94.0 1000
IRAK1 IRAK1 93.0 1000
IRAK3 IRAK3 68.0 1000
IRAK4 IRAK4 88.0 1000
ITK ITK 88.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 100.0 1000
JAK2 JAK2(JH1domain-catalytic) 100.0 1000
JAK3 JAK3(JH1domain-catalytic) 99.0 1000
MAPK8 JNK1 86.0 1000
MAPK9 JNK2 92.0 1000
MAPK10 JNK3 96.0 1000
KIT KIT-autoinhibited 98.0 1000
LATS1 LATS1 88.0 1000
LATS2 LATS2 100.0 1000
LCK LCK 83.0 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 91.0 1000
STK11 LKB1 68.0 1000
STK10 LOK 100.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 98.0 1000
LYN LYN 77.0 1000
MAP3K13 LZK 78.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 100.0 1000
MAP3K15 MAP3K15 100.0 1000
MAP3K2 MAP3K2 100.0 1000
MAP3K3 MAP3K3 73.0 1000
MAP3K4 MAP3K4 89.0 1000
MAP4K2 MAP4K2 100.0 1000
MAP4K3 MAP4K3 99.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 88.0 1000
MAPKAPK2 MAPKAPK2 90.0 1000
MAPKAPK5 MAPKAPK5 100.0 1000
MARK1 MARK1 69.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 100.0 1000
MARK4 MARK4 76.0 1000
MAST1 MAST1 43.0 1000
MAP2K1 MEK1 100.0 1000
MAP2K2 MEK2 96.0 1000
MAP2K3 MEK3 93.0 1000
MAP2K4 MEK4 100.0 1000
MAP2K5 MEK5 60.0 1000
MAP2K6 MEK6 91.0 1000
MELK MELK 59.0 1000
MERTK MERTK 87.0 1000
MET MET(Y1235D) 100.0 1000
MINK1 MINK 100.0 1000
MAP2K7 MKK7 100.0 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 100.0 1000
MYLK3 MLCK 84.0 1000
MAP3K9 MLK1 100.0 1000
MAP3K10 MLK2 71.0 1000
MAP3K11 MLK3 79.0 1000
CDC42BPA MRCKA 86.0 1000
CDC42BPB MRCKB 81.0 1000
STK4 MST1 100.0 1000
MST1R MST1R 100.0 1000
STK3 MST2 92.0 1000
STK24 MST3 83.0 1000
STK26 MST4 100.0 1000
MTOR MTOR 100.0 1000
MUSK MUSK 83.0 1000
MYLK MYLK 95.0 1000
MYLK2 MYLK2 83.0 1000
MYLK4 MYLK4 86.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 82.0 1000
STK38 NDR1 83.0 1000
STK38L NDR2 75.0 1000
NEK1 NEK1 94.0 1000
NEK10 NEK10 100.0 1000
NEK11 NEK11 100.0 1000
NEK2 NEK2 100.0 1000
NEK3 NEK3 40.0 1000
NEK4 NEK4 90.0 1000
NEK5 NEK5 84.0 1000
NEK6 NEK6 97.0 1000
NEK7 NEK7 75.0 1000
NEK9 NEK9 77.0 1000
MAP3K14 NIK 94.0 1000
NIM1K NIM1 79.0 1000
NLK NLK 83.0 1000
OXSR1 OSR1 100.0 1000
MAPK14 p38-alpha 88.0 1000
MAPK11 p38-beta 79.0 1000
MAPK13 p38-delta 100.0 1000
MAPK12 p38-gamma 98.0 1000
PAK1 PAK1 74.0 1000
PAK2 PAK2 76.0 1000
PAK3 PAK3 100.0 1000
PAK4 PAK4 95.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 66.0 1000
CDK17 PCTK2 75.0 1000
CDK18 PCTK3 93.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 100.0 1000
PDPK1 PDPK1 100.0 1000
CDPK1 PFCDPK1(P.falciparum) 97.0 1000
PK5 PFPK5(P.falciparum) 100.0 1000
CDK15 PFTAIRE2 74.0 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 93.0 1000
PHKG2 PHKG2 96.0 1000
PIK3C2B PIK3C2B 97.0 1000
PIK3C2G PIK3C2G 88.0 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 65.0 1000
PIK3CD PIK3CD 98.0 1000
PIK3CG PIK3CG 83.0 1000
PI4KB PIK4CB 82.0 1000
PIKFYVE PIKFYVE 54.0 1000
PIM1 PIM1 88.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 86.0 1000
PIP5K1A PIP5K1A 100.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 100.0 1000
PIP4K2C PIP5K2C 91.0 1000
PRKACA PKAC-alpha 90.0 1000
PRKACB PKAC-beta 81.0 1000
PKMYT1 PKMYT1 85.0 1000
PKN1 PKN1 100.0 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 87.0 1000
PLK1 PLK1 77.0 1000
PLK2 PLK2 100.0 1000
PLK3 PLK3 86.0 1000
PLK4 PLK4 100.0 1000
PRKCD PRKCD 79.0 1000
PRKCE PRKCE 100.0 1000
PRKCH PRKCH 86.0 1000
PRKCI PRKCI 72.0 1000
PRKCQ PRKCQ 93.0 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 83.0 1000
PRKD3 PRKD3 85.0 1000
PRKG1 PRKG1 85.0 1000
PRKG2 PRKG2 100.0 1000
EIF2AK2 PRKR 96.0 1000
PRKX PRKX 88.0 1000
PRPF4B PRP4 100.0 1000
PTK2B PYK2 83.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 97.0 1000
RET RET(V804M) 94.0 1000
RIOK1 RIOK1 85.0 1000
RIOK2 RIOK2 90.0 1000
RIOK3 RIOK3 82.0 1000
RIPK1 RIPK1 91.0 1000
RIPK2 RIPK2 74.0 1000
RIPK4 RIPK4 76.0 1000
DSTYK RIPK5 100.0 1000
ROCK1 ROCK1 100.0 1000
ROCK2 ROCK2 100.0 1000
ROS1 ROS1 77.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 88.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 91.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 87.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 79.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 91.0 1000
RPS6KB1 S6K1 100.0 1000
SBK1 SBK1 100.0 1000
SGK1 SGK 94.0 1000
SBK3 SgK110 84.0 1000
SGK2 SGK2 91.0 1000
SGK3 SGK3 100.0 1000
SIK1 SIK 87.0 1000
SIK2 SIK2 87.0 1000
SLK SLK 81.0 1000
NUAK2 SNARK 100.0 1000
SNRK SNRK 100.0 1000
SRC SRC 99.0 1000
SRMS SRMS 95.0 1000
SRPK1 SRPK1 96.0 1000
SRPK2 SRPK2 100.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 75.0 1000
STK33 STK33 51.0 1000
STK35 STK35 80.0 1000
STK36 STK36 91.0 1000
STK39 STK39 50.0 1000
SYK SYK 82.0 1000
MAP3K7 TAK1 89.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 88.0 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 59.0 1000
TEC TEC 84.0 1000
TESK1 TESK1 85.0 1000
TGFBR1 TGFBR1 94.0 1000
TGFBR2 TGFBR2 100.0 1000
TIE1 TIE1 92.0 1000
TEK TIE2 84.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 92.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 100.0 1000
TNK2 TNK2 100.0 1000
TNNI3K TNNI3K 73.0 1000
NTRK1 TRKA 80.0 1000
NTRK2 TRKB 100.0 1000
NTRK3 TRKC 100.0 1000
TRPM6 TRPM6 100.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 81.0 1000
TTK TTK 77.0 1000
TXK TXK 87.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 100.0 1000
TYRO3 TYRO3 100.0 1000
ULK1 ULK1 100.0 1000
ULK2 ULK2 96.0 1000
ULK3 ULK3 94.0 1000
KDR VEGFR2 100.0 1000
PIK3C3 VPS34 100.0 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 88.0 1000
WEE2 WEE2 88.0 1000
WNK1 WNK1 100.0 1000
WNK2 WNK2 98.0 1000
WNK3 WNK3 95.0 1000
WNK4 WNK4 99.0 1000
STK32A YANK1 100.0 1000
STK32B YANK2 89.0 1000
STK32C YANK3 99.0 1000
YES1 YES 99.0 1000
STK25 YSK1 87.0 1000
MAP3K19 YSK4 91.0 1000
MAP3K20 ZAK 100.0 1000
ZAP70 ZAP70 100.0 1000

NVS-MALT1-C


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 96.0 1000
ABL1 ABL1-phosphorylated 59.0 1000
ABL2 ABL2 84.0 1000
ACVR1 ACVR1 85.0 1000
ACVR1B ACVR1B 100.0 1000
ACVR2A ACVR2A 100.0 1000
ACVR2B ACVR2B 100.0 1000
ACVRL1 ACVRL1 100.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 96.0 1000
AKT1 AKT1 89.0 1000
AKT2 AKT2 91.0 1000
AKT3 AKT3 65.0 1000
ALK ALK(L1196M) 94.0 1000
PRKAA1 AMPK-alpha1 92.0 1000
PRKAA2 AMPK-alpha2 78.0 1000
ANKK1 ANKK1 100.0 1000
NUAK1 ARK5 99.0 1000
MAP3K5 ASK1 81.0 1000
MAP3K6 ASK2 100.0 1000
AURKA AURKA 100.0 1000
AURKB AURKB 74.0 1000
AURKC AURKC 85.0 1000
AXL AXL 77.0 1000
BMP2K BIKE 91.0 1000
BLK BLK 56.0 1000
BMPR1A BMPR1A 100.0 1000
BMPR1B BMPR1B 100.0 1000
BMPR2 BMPR2 84.0 1000
BMX BMX 83.0 1000
BRAF BRAF(V600E) 85.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 93.0 1000
BRSK2 BRSK2 90.0 1000
BTK BTK 100.0 1000
BUB1 BUB1 100.0 1000
CAMK1 CAMK1 82.0 1000
PNCK CAMK1B 100.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 83.0 1000
CAMK2B CAMK2B 96.0 1000
CAMK2D CAMK2D 100.0 1000
CAMK2G CAMK2G 84.0 1000
CAMK4 CAMK4 100.0 1000
CAMKK1 CAMKK1 98.0 1000
CAMKK2 CAMKK2 100.0 1000
CASK CASK 100.0 1000
CDK11B CDC2L1 100.0 1000
CDK11A CDC2L2 100.0 1000
CDK13 CDC2L5 100.0 1000
CDK19 CDK11 81.0 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 88.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 99.0 1000
CDK7 CDK7 100.0 1000
CDK8 CDK8 96.0 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 74.0 1000
CDKL2 CDKL2 88.0 1000
CDKL3 CDKL3 73.0 1000
CDKL5 CDKL5 89.0 1000
CHEK1 CHEK1 95.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 97.0 1000
CLK1 CLK1 82.0 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 87.0 1000
CLK4 CLK4 92.0 1000
CSF1R CSF1R-autoinhibited 88.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 72.0 1000
CSNK1A1L CSNK1A1L 84.0 1000
CSNK1D CSNK1D 100.0 1000
CSNK1E CSNK1E 59.0 1000
CSNK1G1 CSNK1G1 99.0 1000
CSNK1G2 CSNK1G2 84.0 1000
CSNK1G3 CSNK1G3 71.0 1000
CSNK2A1 CSNK2A1 100.0 1000
CSNK2A2 CSNK2A2 100.0 1000
MATK CTK 98.0 1000
DAPK1 DAPK1 89.0 1000
DAPK2 DAPK2 41.0 1000
DAPK3 DAPK3 47.0 1000
DCLK1 DCAMKL1 75.0 1000
DCLK2 DCAMKL2 95.0 1000
DCLK3 DCAMKL3 100.0 1000
DDR1 DDR1 100.0 1000
DDR2 DDR2 100.0 1000
MAP3K12 DLK 100.0 1000
DMPK DMPK 91.0 1000
CDC42BPG DMPK2 86.0 1000
STK17A DRAK1 90.0 1000
STK17B DRAK2 98.0 1000
DYRK1A DYRK1A 92.0 1000
DYRK1B DYRK1B 75.0 1000
DYRK2 DYRK2 95.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 100.0 1000
EPHA1 EPHA1 97.0 1000
EPHA2 EPHA2 83.0 1000
EPHA3 EPHA3 90.0 1000
EPHA4 EPHA4 100.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 87.0 1000
EPHA8 EPHA8 91.0 1000
EPHB1 EPHB1 92.0 1000
EPHB2 EPHB2 92.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 100.0 1000
ERBB2 ERBB2 70.0 1000
ERBB3 ERBB3 100.0 1000
ERBB4 ERBB4 77.0 1000
MAPK3 ERK1 86.0 1000
MAPK1 ERK2 100.0 1000
MAPK6 ERK3 91.0 1000
MAPK4 ERK4 100.0 1000
MAPK7 ERK5 100.0 1000
MAPK15 ERK8 81.0 1000
ERN1 ERN1 100.0 1000
PTK2 FAK 90.0 1000
FER FER 89.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 91.0 1000
FGFR2 FGFR2 84.0 1000
FGFR3 FGFR3(G697C) 84.0 1000
FGFR4 FGFR4 92.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 85.0 1000
FLT3 FLT3-autoinhibited 94.0 1000
FLT4 FLT4 84.0 1000
FRK FRK 91.0 1000
FYN FYN 95.0 1000
GAK GAK 93.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 68.0 1000
GRK1 GRK1 86.0 1000
GRK2 GRK2 92.0 1000
GRK3 GRK3 91.0 1000
GRK4 GRK4 100.0 1000
GRK7 GRK7 100.0 1000
GSK3A GSK3A 94.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 100.0 1000
HIPK1 HIPK1 56.0 1000
HIPK2 HIPK2 100.0 1000
HIPK3 HIPK3 100.0 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 100.0 1000
HUNK HUNK 100.0 1000
CILK1 ICK 96.0 1000
IGF1R IGF1R 97.0 1000
CHUK IKK-alpha 100.0 1000
IKBKB IKK-beta 100.0 1000
IKBKE IKK-epsilon 100.0 1000
INSR INSR 95.0 1000
INSRR INSRR 89.0 1000
IRAK1 IRAK1 82.0 1000
IRAK3 IRAK3 86.0 1000
IRAK4 IRAK4 89.0 1000
ITK ITK 94.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 89.0 1000
JAK2 JAK2(JH1domain-catalytic) 98.0 1000
JAK3 JAK3(JH1domain-catalytic) 98.0 1000
MAPK8 JNK1 69.0 1000
MAPK9 JNK2 76.0 1000
MAPK10 JNK3 78.0 1000
KIT KIT-autoinhibited 85.0 1000
LATS1 LATS1 98.0 1000
LATS2 LATS2 88.0 1000
LCK LCK 84.0 1000
LIMK1 LIMK1 92.0 1000
LIMK2 LIMK2 87.0 1000
STK11 LKB1 78.0 1000
STK10 LOK 98.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 95.0 1000
LYN LYN 97.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 96.0 1000
MAP3K15 MAP3K15 100.0 1000
MAP3K2 MAP3K2 100.0 1000
MAP3K3 MAP3K3 100.0 1000
MAP3K4 MAP3K4 89.0 1000
MAP4K2 MAP4K2 100.0 1000
MAP4K3 MAP4K3 94.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 100.0 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 100.0 1000
MARK1 MARK1 81.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 100.0 1000
MARK4 MARK4 89.0 1000
MAST1 MAST1 29.0 1000
MAP2K1 MEK1 100.0 1000
MAP2K2 MEK2 97.0 1000
MAP2K3 MEK3 90.0 1000
MAP2K4 MEK4 100.0 1000
MAP2K5 MEK5 91.0 1000
MAP2K6 MEK6 92.0 1000
MELK MELK 52.0 1000
MERTK MERTK 79.0 1000
MET MET(Y1235D) 85.0 1000
MINK1 MINK 100.0 1000
MAP2K7 MKK7 100.0 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 85.0 1000
MYLK3 MLCK 87.0 1000
MAP3K9 MLK1 81.0 1000
MAP3K10 MLK2 77.0 1000
MAP3K11 MLK3 85.0 1000
CDC42BPA MRCKA 94.0 1000
CDC42BPB MRCKB 89.0 1000
STK4 MST1 100.0 1000
MST1R MST1R 100.0 1000
STK3 MST2 100.0 1000
STK24 MST3 89.0 1000
STK26 MST4 100.0 1000
MTOR MTOR 100.0 1000
MUSK MUSK 88.0 1000
MYLK MYLK 98.0 1000
MYLK2 MYLK2 88.0 1000
MYLK4 MYLK4 83.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 100.0 1000
STK38 NDR1 88.0 1000
STK38L NDR2 75.0 1000
NEK1 NEK1 100.0 1000
NEK10 NEK10 100.0 1000
NEK11 NEK11 100.0 1000
NEK2 NEK2 94.0 1000
NEK3 NEK3 61.0 1000
NEK4 NEK4 90.0 1000
NEK5 NEK5 88.0 1000
NEK6 NEK6 100.0 1000
NEK7 NEK7 91.0 1000
NEK9 NEK9 90.0 1000
MAP3K14 NIK 90.0 1000
NIM1K NIM1 85.0 1000
NLK NLK 84.0 1000
OXSR1 OSR1 100.0 1000
MAPK14 p38-alpha 83.0 1000
MAPK11 p38-beta 86.0 1000
MAPK13 p38-delta 100.0 1000
MAPK12 p38-gamma 92.0 1000
PAK1 PAK1 83.0 1000
PAK2 PAK2 81.0 1000
PAK3 PAK3 100.0 1000
PAK4 PAK4 100.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 72.0 1000
CDK17 PCTK2 100.0 1000
CDK18 PCTK3 99.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 100.0 1000
PDPK1 PDPK1 97.0 1000
CDPK1 PFCDPK1(P.falciparum) 78.0 1000
PK5 PFPK5(P.falciparum) 100.0 1000
CDK15 PFTAIRE2 94.0 1000
CDK14 PFTK1 99.0 1000
PHKG1 PHKG1 96.0 1000
PHKG2 PHKG2 44.0 1000
PIK3C2B PIK3C2B 89.0 1000
PIK3C2G PIK3C2G 88.0 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 72.0 1000
PIK3CD PIK3CD 87.0 1000
PIK3CG PIK3CG 87.0 1000
PI4KB PIK4CB 100.0 1000
PIKFYVE PIKFYVE 65.0 1000
PIM1 PIM1 100.0 1000
PIM2 PIM2 95.0 1000
PIM3 PIM3 97.0 1000
PIP5K1A PIP5K1A 89.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 100.0 1000
PIP4K2C PIP5K2C 58.0 1000
PRKACA PKAC-alpha 87.0 1000
PRKACB PKAC-beta 89.0 1000
PKMYT1 PKMYT1 99.0 1000
PKN1 PKN1 99.0 1000
PKN2 PKN2 88.0 1000
PKNB PKNB(M.tuberculosis) 100.0 1000
PLK1 PLK1 87.0 1000
PLK2 PLK2 100.0 1000
PLK3 PLK3 84.0 1000
PLK4 PLK4 100.0 1000
PRKCD PRKCD 90.0 1000
PRKCE PRKCE 94.0 1000
PRKCH PRKCH 78.0 1000
PRKCI PRKCI 76.0 1000
PRKCQ PRKCQ 98.0 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 86.0 1000
PRKD3 PRKD3 93.0 1000
PRKG1 PRKG1 92.0 1000
PRKG2 PRKG2 100.0 1000
EIF2AK2 PRKR 88.0 1000
PRKX PRKX 84.0 1000
PRPF4B PRP4 91.0 1000
PTK2B PYK2 100.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 100.0 1000
RET RET(V804M) 87.0 1000
RIOK1 RIOK1 91.0 1000
RIOK2 RIOK2 89.0 1000
RIOK3 RIOK3 90.0 1000
RIPK1 RIPK1 84.0 1000
RIPK2 RIPK2 83.0 1000
RIPK4 RIPK4 100.0 1000
DSTYK RIPK5 100.0 1000
ROCK1 ROCK1 100.0 1000
ROCK2 ROCK2 100.0 1000
ROS1 ROS1 82.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 70.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 99.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 89.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 98.0 1000
RPS6KB1 S6K1 90.0 1000
SBK1 SBK1 100.0 1000
SGK1 SGK 89.0 1000
SBK3 SgK110 81.0 1000
SGK2 SGK2 99.0 1000
SGK3 SGK3 100.0 1000
SIK1 SIK 85.0 1000
SIK2 SIK2 92.0 1000
SLK SLK 83.0 1000
NUAK2 SNARK 100.0 1000
SNRK SNRK 100.0 1000
SRC SRC 98.0 1000
SRMS SRMS 100.0 1000
SRPK1 SRPK1 95.0 1000
SRPK2 SRPK2 99.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 51.0 1000
STK35 STK35 90.0 1000
STK36 STK36 94.0 1000
STK39 STK39 50.0 1000
SYK SYK 90.0 1000
MAP3K7 TAK1 84.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 94.0 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 77.0 1000
TEC TEC 82.0 1000
TESK1 TESK1 83.0 1000
TGFBR1 TGFBR1 95.0 1000
TGFBR2 TGFBR2 100.0 1000
TIE1 TIE1 96.0 1000
TEK TIE2 90.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 100.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 87.0 1000
TNK2 TNK2 84.0 1000
TNNI3K TNNI3K 91.0 1000
NTRK1 TRKA 93.0 1000
NTRK2 TRKB 100.0 1000
NTRK3 TRKC 100.0 1000
TRPM6 TRPM6 100.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 79.0 1000
TTK TTK 100.0 1000
TXK TXK 84.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 100.0 1000
TYRO3 TYRO3 99.0 1000
ULK1 ULK1 100.0 1000
ULK2 ULK2 92.0 1000
ULK3 ULK3 97.0 1000
KDR VEGFR2 95.0 1000
PIK3C3 VPS34 100.0 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 92.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 98.0 1000
WNK2 WNK2 100.0 1000
WNK3 WNK3 84.0 1000
WNK4 WNK4 99.0 1000
STK32A YANK1 100.0 1000
STK32B YANK2 95.0 1000
STK32C YANK3 82.0 1000
YES1 YES 100.0 1000
STK25 YSK1 84.0 1000
MAP3K19 YSK4 77.0 1000
MAP3K20 ZAK 100.0 1000
ZAP70 ZAP70 100.0 1000

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NVS-MALT1

Percent protease inhibition was determined at 10 µM probe concentration.

Conclusion: No cross reactivity among proteases owing to allosteric mechanism.

Target protein HGNC name Species % Inhibition at 10 µM
Cathepsin B (h) CTSB Homo sapiens -4.0
Cathepsin D (h) CTSD Homo sapiens 0.0
Cathepsin G (h) CTSG Homo sapiens 7.0
Cathepsin K (h) CTSK Homo sapiens 2.0
Cathepsin L (h) CTSL Homo sapiens -3.0
Cathepsin S (h) CTSS Homo sapiens 7.0
Caspase 3 (h) CASP3 Homo sapiens -1.0
Chymase (h) CMA1 Homo sapiens -3.0
Neutrophil elastase 2 (h) ELANE Homo sapiens -1.0
Factor VIIa (h) F7 Homo sapiens -1.0
Factor Xa (h) F10 Homo sapiens -9.0
MMP-8 (h) MMP8 Homo sapiens 0.0
Thrombin (h) F2 Homo sapiens 0.0
Trypsin (h) Homo sapiens 0.8
Plasma Kallikrein KLKB1 Homo sapiens 5.0