In cells

Use at 1 µM and not higher than 10 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

Tested in mouse and rat (3 mpk po; 1 mpk iv) and in dog (0.3 mpk po; 0.1 mpk iv). NVS-MALT1 is fully efficacious in rat Sheep Red Blood Cell (SRBC) model at 3 mg/kg, p.o.