Potency data for probe UCSF924 and control UCSF924NC
In vitro potency
| Target name | Target information | Species | Assay description | UCSF924 | UCSF924NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| DRD4 | Homo sapiens | Radioligand binding assay (DRD4) | Ki = 3 nM | Ki = 7.5 µM | PMID: 29051383 | |
| DRD2 | Homo sapiens | Radioligand binding assay (DRD2) | Ki > 10 µM | Ki > 10 µM | PMID: 29051383 |
In cell potency
| Target name | Target information | Species | Assay description | UCSF924 | UCSF924NC | Publication of assay conditions |
|---|---|---|---|---|---|---|
| DRD3 | Homo sapiens | Radioligand binding assay (DRD3) | Ki > 10 µM | Ki > 10 µM | PMID: 29051383 | |
| DRD4 | DRD4 transiently expressing HEK293T cells | Homo sapiens | Split luciferase based cAMP receptor assay | EC50 = 4.2 nM | EC50 = not detectable | PMID: 29051383 |
| DRD4 | Homo sapiens | BRET-Gi dissociation assay | EC50 = 0.2 nM | PMID: 29051383 |