Potency data for probe WEB2086 and control WEB2387
In vitro potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| PTAFR | Homo sapiens | PAF Receptor Binding | KD = 660 nM |
In cell potency
| Target name | Target information | Species | Assay description | Probe result (SD) | Control result (SD) | Publication of assay conditions |
|---|---|---|---|---|---|---|
| PTAFR | Human platelets | Homo sapiens | Competition with [3H]PAF binding to human platelets | Ki = 9.900 nM | PMID: 3342883 | |
| PTAFR | Human platelets | Homo sapiens | Inhibition of PAF-induced human platelet aggregation: Platelet-rich plasma isolated from human venous blood was collected, and aggregation was induced by addition of PAF. The aggregation inhibitory effect of the antagonists was determined by adding various concentrations to the reaction mixture one minute prior to the addition of PAF. | IC50 = 170 nM (n=4) | IC50 = 8790 nM (n=4) | PMID: 3598913 |
| PTAFR | Human neutrophils | Homo sapiens | Inhibition of PAF-induced human neutrophil aggregation | IC50 = 360 nM (n=4) | PMID: 3598913 |