Selectivity data for probe A-446 and control A-426
Jump to control PDSP data
A-446
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1A | HTR1A | 1.90 | ||
| 5-HT1E | HTR1E | -1.42 | ||
| 5-HT2A | HTR2A | -2.63 | ||
| 5-HT2B | HTR2B | 1.83 | ||
| 5-HT2C | HTR2C | -13.68 | ||
| 5-HT3 | HTR3A | 1.72 | ||
| 5-HT5A | HTR5A | 4.08 | ||
| 5-HT6 | HTR6 | -4.23 | ||
| 5-HT7A | HTR7 | -46.40 | > 10000.00 | < 5.00 |
| Alpha1A | ADRA1A | -20.80 | ||
| Alpha1B | ADRA1B | -23.40 | ||
| Alpha1D | ADRA1D | -19.53 | ||
| Alpha2A | ADRA2A | 12.16 | ||
| Alpha2B | ADRA2B | -6.10 | ||
| Alpha2C | ADRA2C | 13.95 | ||
| Beta1 | ADRB1 | 1.03 | ||
| Beta2 | ADRB2 | -8.05 | ||
| GABAA/BZP | -15.88 | |||
| D1 | DRD1 | -24.26 | ||
| D2 | DRD2 | -11.58 | ||
| D3 | DRD3 | -3.72 | ||
| D4 | DRD4 | -7.36 | ||
| D5 | DRD5 | -17.99 | ||
| DAT | SLC6A3 | 33.45 | ||
| DOR | OPRD1 | -2.96 | ||
| H1 | HRH1 | 21.34 | ||
| H3 | HRH3 | -23.66 | ||
| H4 | HRH4 | 18.33 | ||
| KOR | OPRK1 | 2.85 | ||
| M1 | CHRM1 | 14.57 | ||
| M2 | CHRM2 | -14.38 | ||
| M3 | CHRM3 | 9.66 | ||
| M4 | CHRM4 | -9.24 | ||
| M5 | CHRM5 | 15.03 | ||
| MOR | OPRM1 | -3.29 | ||
| NET | SLC6A2 | -11.65 | ||
| GABA/PBR | -168.18 | > 10000.00 | < 5.00 | |
| SERT | SLC6A4 | -31.32 | ||
| Sigma 1 | SIGMAR1 | 9.03 | ||
| Sigma 2 | TMEM97 | 6.42 | ||
| 5-HT1B | HTR1B | 11.22 | ||
| 5-HT1D | HTR1D | 55.12 | 6453.57 | 5.19 |
| Beta3 | ADRB3 | -10.06 | ||
| H2 | HRH2 | -5.22 |