Selectivity data for probe BAY-3153 and control BAY-173
Jump to control PDSP data
BAY-3153
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1B | HTR1B | -2.86 | ||
| 5-HT1D | HTR1D | -2.08 | ||
| 5-HT1E | HTR1E | -15.99 | ||
| 5-HT2B | HTR2B | 10.50 | ||
| Alpha1A | ADRA1A | 16.97 | ||
| Alpha1B | ADRA1B | -12.09 | ||
| H1 | HRH1 | 11.15 | ||
| H2 | HRH2 | 27.73 | ||
| D3 | DRD3 | 1.58 | ||
| D4 | DRD4 | 15.47 | ||
| D5 | DRD5 | 2.54 | ||
| DAT | SLC6A3 | 3.92 | ||
| M2 | CHRM2 | 8.64 | ||
| M3 | CHRM3 | 8.61 | ||
| M4 | CHRM4 | -3.29 | ||
| Sigma 1 | SIGMAR1 | 84.98 | 1828.52 | 5.74 |
| 5-HT2C | HTR2C | 4.08 | ||
| 5-HT3 | HTR3A | -1.97 | ||
| 5-HT6 | HTR6 | -8.16 | ||
| Alpha1D | ADRA1D | 7.09 | ||
| Alpha2A | ADRA2A | -10.96 | ||
| Alpha2B | ADRA2B | -19.91 | ||
| Alpha2C | ADRA2C | 2.17 | ||
| Beta2 | ADRB2 | -4.63 | ||
| D1 | DRD1 | 40.33 | ||
| D2 | DRD2 | 7.26 | ||
| DOR | OPRD1 | 10.33 | ||
| KOR | OPRK1 | 53.60 | 3005.38 | 5.52 |
| MOR | OPRM1 | 5.82 | ||
| SERT | SLC6A4 | 33.43 | ||
| H4 | HRH4 | -13.92 | ||
| 5-HT7A | HTR7 | -15.45 | ||
| Beta1 | ADRB1 | -26.17 | ||
| Beta3 | ADRB3 | -5.38 | ||
| GABAA/BZP | -6.17 | |||
| H3 | HRH3 | 17.30 | ||
| M5 | CHRM5 | -4.29 | ||
| NET | SLC6A2 | 1.24 | ||
| GABA/PBR | 54.19 | 1805.09 | 5.74 | |
| 5-HT1A | HTR1A | -9.03 | ||
| GABAA | 18.57 | |||
| 5-HT2A | HTR2A | 6.74 | ||
| 5-HT5A | HTR5A | 1.70 | ||
| Sigma 2 | TMEM97 | 83.60 | 1476.05 | 5.83 |
BAY-173
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| M1 | SLC6A3 | -3.85 | ||
| 5-HT2A | HTR2A | 7.31 | ||
| 5-HT5A | HTR5A | -1.82 | ||
| Sigma 2 | TMEM97 | 76.48 | 2169.70 | 5.66 |
| 5-HT1A | HTR1A | -16.00 | ||
| GABAA | 20.02 | |||
| 5-HT1D | HTR1D | -7.50 | ||
| 5-HT7A | HTR7 | -13.85 | ||
| Beta1 | ADRB1 | 6.12 | ||
| Beta3 | ADRB3 | -9.84 | ||
| GABAA/BZP | 0.65 | |||
| D1 | DRD1 | -16.49 | ||
| H3 | HRH3 | 9.39 | ||
| M5 | CHRM5 | -1.65 | ||
| NET | SLC6A2 | -4.52 | ||
| GABA/PBR | -8.33 | |||
| H4 | HRH4 | -3.31 | ||
| 5-HT1B | HTR1B | -6.45 | ||
| 5-HT1E | HTR1E | -25.43 | ||
| 5-HT2B | HTR2B | 14.76 | ||
| Alpha1A | ADRA1A | 7.02 | ||
| Alpha1B | ADRA1B | 0.94 | ||
| H1 | HRH1 | 14.28 | ||
| H2 | HRH2 | 8.13 | ||
| D3 | DRD3 | 2.75 | ||
| D4 | DRD4 | 51.55 | > 10000.00 | < 5.00 |
| D5 | DRD5 | 6.84 | ||
| M2 | CHRM2 | 1.89 | ||
| M3 | CHRM3 | 24.07 | ||
| M4 | CHRM4 | -6.12 | ||
| Sigma 1 | SIGMAR1 | 69.54 | 8245.18 | 5.08 |
| 5-HT2C | HTR2C | -2.02 | ||
| 5-HT3 | HTR3A | -7.03 | ||
| Alpha1D | ADRA1D | -7.34 | ||
| Alpha2A | ADRA2A | 11.34 | ||
| Alpha2B | ADRA2B | -34.32 | > 10000.00 | < 5.00 |
| Alpha2C | ADRA2C | 14.45 | ||
| Beta2 | ADRB2 | -7.55 | ||
| D2 | DRD2 | -16.50 | ||
| DOR | OPRD1 | -14.99 | ||
| KOR | OPRK1 | 18.73 | ||
| MOR | OPRM1 | 4.45 | ||
| SERT | SLC6A4 | 70.26 | 1460.83 | 5.84 |
| 5-HT6 | HTR6 | 5.38 |