Selectivity data for probe BAY-707 and control BAY-604
Jump to control PDSP data
BAY-707
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| 5-HT1A | HTR1A | 69.80 | > 10000.00 | < 5.00 |
| 5-HT1B | HTR1B | -1.66 | ||
| 5-HT1D | HTR1D | -7.56 | ||
| 5-HT1E | HTR1E | 10.59 | ||
| 5-HT2A | HTR2A | -7.89 | ||
| 5-HT2B | HTR2B | 47.12 | ||
| 5-HT2C | HTR2C | -4.02 | ||
| 5-HT3 | HTR3A | -1.37 | ||
| 5-HT5A | HTR5A | -8.05 | ||
| 5-HT6 | HTR6 | -8.52 | ||
| 5-HT7A | HTR7 | -4.45 | ||
| D1 | DRD1 | 1.92 | ||
| D2 | DRD2 | 12.27 | ||
| D3 | DRD3 | -7.82 | ||
| D4 | DRD4 | -3.84 | ||
| D5 | DRD5 | 34.31 | ||
| SERT | SLC6A4 | -17.27 | ||
| NET | SLC6A2 | 40.18 | ||
| DAT | SLC6A3 | 25.50 | ||
| MOR | OPRM1 | 24.84 | ||
| DOR | OPRD1 | -0.04 | ||
| KOR | OPRK1 | 13.08 | ||
| GABAA | 28.21 | |||
| H1 | HRH1 | 4.94 | ||
| H2 | HRH2 | 1.31 | ||
| H3 | HRH3 | 40.48 | ||
| H4 | HRH4 | 0.03 | ||
| Alpha1A | ADRA1A | 1.88 | ||
| Alpha1B | ADRA1B | -2.40 | ||
| Alpha2A | ADRA2A | 18.07 | ||
| Alpha2B | ADRA2B | 34.39 | ||
| Alpha2C | ADRA2C | 3.16 | ||
| Beta1 | ADRB1 | -11.66 | ||
| Beta2 | ADRB2 | -6.09 | ||
| M1 | CHRM1 | 21.68 | ||
| M2 | CHRM2 | -1.26 | ||
| M3 | CHRM3 | -11.60 | ||
| M4 | CHRM4 | -13.82 | ||
| M5 | CHRM5 | -4.95 | ||
| Beta3 | ADRB3 | 14.34 | ||
| GABAA/BZP | 57.31 | 1527.00 | 5.80 | |
| GABA/PBR | 30.11 | |||
| Alpha1D | ADRA1D | 8.58 | ||
| Sigma 2 | TMEM97 | 34.60 | ||
| Sigma 1 | SIGMAR1 | 24.30 |
BAY-604
Compound concentration: 10 µM| Receptor | HGNC target name | Inhibition [%] (Primary experimental value) | Ki [nM] (Secondary experimental value) | pKi |
|---|---|---|---|---|
| GABA/PBR | 17.17 | |||
| Beta1 | ADRB1 | -10.13 | ||
| Beta3 | ADRB3 | -9.19 | ||
| GABAA/BZP | 84.23 | 224.22 average (n=2) | 6.72 | |
| DAT | SLC6A3 | -25.15 | ||
| Alpha1A | ADRA1A | 3.94 | ||
| Alpha1B | ADRA1B | 5.71 | ||
| Alpha1D | ADRA1D | -8.10 | ||
| Alpha2A | ADRA2A | 16.92 | ||
| Alpha2B | ADRA2B | -2.44 | ||
| 5-HT1A | HTR1A | -1.88 | ||
| 5-HT1B | HTR1B | -8.46 | ||
| 5-HT2A | HTR2A | -1.68 | ||
| 5-HT2B | HTR2B | 2.79 | ||
| 5-HT6 | HTR6 | 31.93 | ||
| 5-HT7A | HTR7 | -1.21 | ||
| D2 | DRD2 | -1.89 | ||
| D3 | DRD3 | 12.13 | ||
| 5-HT1D | HTR1D | -0.31 | ||
| 5-HT1E | HTR1E | 9.36 | ||
| 5-HT2C | HTR2C | 46.24 | ||
| 5-HT3 | HTR3A | 18.55 | ||
| 5-HT5A | HTR5A | -16.79 | ||
| Beta2 | ADRB2 | 27.31 | ||
| D1 | DRD1 | 14.19 | ||
| DOR | OPRD1 | 2.73 | ||
| H1 | HRH1 | 26.01 | ||
| H2 | HRH2 | -3.91 | ||
| H3 | HRH3 | -6.16 | ||
| M1 | CHRM1 | 11.90 | ||
| M2 | CHRM2 | 7.19 | ||
| M3 | CHRM3 | 38.05 | ||
| M4 | CHRM4 | 5.75 | ||
| M5 | CHRM5 | -0.90 | ||
| SERT | SLC6A4 | -11.38 | ||
| Sigma 1 | SIGMAR1 | 24.46 | ||
| Sigma 2 | TMEM97 | 30.40 | ||
| D4 | DRD4 | 77.62 | 735.98 average (n=2) | 6.15 |
| D5 | DRD5 | -20.58 | ||
| H4 | HRH4 | 5.51 | ||
| KOR | OPRK1 | 14.59 | ||
| MOR | OPRM1 | 0.08 | ||
| NET | SLC6A2 | 5.35 | ||
| Alpha2C | ADRA2C | -1.28 | ||
| GABAA | -1.39 |