In cells

Use between 1 nM to 1 µM.

Use the recommended concentration to avoid off-target toxicity and/or off-target activity. Using concentrations that are higher than recommended could lead to false positive or confounding results.

In vivo

NUDT1 inhibition in mono- or combination-therapies has no effect on in vivo tumor growth. Dosage up to 100 mg/kg tolerated with no significant body weight loss in mice.