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Selectivity data for probe BAY-826 and control BAY-309


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BAY-826


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
Alpha2C ADRA2C -7.91
5-HT2C HTR2C 34.54
5-HT3 HTR3A 18.44
5-HT5A HTR5A 9.57
Beta2 ADRB2 25.55
DOR OPRD1 18.69
H1 HRH1 25.27
H2 HRH2 25.56
H3 HRH3 -5.88
M1 CHRM1 24.76
M2 CHRM2 10.50
M3 CHRM3 10.53
M4 CHRM4 14.95
M5 CHRM5 16.07
SERT SLC6A4 11.07
Alpha1A ADRA1A -3.02
Alpha1B ADRA1B -0.87
Alpha1D ADRA1D -2.46
Alpha2A ADRA2A 11.07
Alpha2B ADRA2B 18.08
Sigma 1 SIGMAR1 -4.84
Sigma 2 TMEM97 64.40 983.68 average (n=2) 6.02
5-HT1A HTR1A -6.68
5-HT1B HTR1B 14.43
5-HT1D HTR1D 9.27
5-HT1E HTR1E 3.57
5-HT2A HTR2A -4.70
5-HT2B HTR2B -7.00
5-HT6 HTR6 -17.21
5-HT7A HTR7 -3.40
D1 DRD1 4.82
D2 DRD2 8.74
D3 DRD3 -5.85
D4 DRD4 16.38
D5 DRD5 -22.52
DAT SLC6A3 10.65
H4 HRH4 11.88
KOR OPRK1 89.39 124.61 average (n=2) 6.95
MOR OPRM1 20.68
NET SLC6A2 1.95
GABAA/BZP -20.19
GABAA -6.93
GABA/PBR 59.13 217.26 average (n=2) 6.68
Beta1 ADRB1 9.41
Beta3 ADRB3 52.29 7099.67 average (n=2) 5.18

BAY-309


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A 39.89
5-HT1B HTR1B 36.82
5-HT1D HTR1D 15.41
5-HT1E HTR1E 19.93
5-HT2A HTR2A 21.95
5-HT2B HTR2B 60.35 2146.00 5.67
5-HT2C HTR2C 65.95 4863.00 5.31
5-HT3 HTR3A -8.73
5-HT5A HTR5A -4.71
5-HT6 HTR6 5.64
5-HT7A HTR7 6.71
D1 DRD1 20.61
D2 DRD2 62.09 > 10000.00 < 5.00
D3 DRD3 -12.71
D4 DRD4 12.43
D5 DRD5 34.85
SERT SLC6A4 19.22
NET SLC6A2 62.94 > 10000.00 average (n=2) < 5.00
DAT SLC6A3 38.15
MOR OPRM1 59.98 6987.00 5.16
DOR OPRD1 58.45 1733.00 average (n=3) 5.76
KOR OPRK1 64.80 > 10000.00 average (n=3) < 5.00
GABAA -4.43
H2 HRH2 46.15
H3 HRH3 -20.06
Alpha1A ADRA1A 5.89
Alpha1B ADRA1B -8.99
Alpha2A ADRA2A 15.84
Alpha2B ADRA2B 11.94
Alpha2C ADRA2C -5.04
Beta1 ADRB1 -7.94
Beta2 ADRB2 -7.80
M1 CHRM1 9.27
M2 CHRM2 32.68
M3 CHRM3 16.32
M4 CHRM4 14.60
M5 CHRM5 8.74
Beta3 ADRB3 32.29
GABAA/BZP 33.28
GABA/PBR 67.79 10.90 average (n=4) 8.03
Alpha1D ADRA1D 27.73
Sigma 2 TMEM97 68.71 796.12 average (n=3) 6.10
Sigma 1 SIGMAR1 19.34

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
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BAY-826


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 95.9 100
ABL1 ABL1-phosphorylated 74.6 100
ABL2 ABL2 67.8 100
ACVR1 ACVR1 83.3 100
ACVR1B ACVR1B 100.0 100
ACVR2A ACVR2A 100.0 100
ACVR2B ACVR2B 88.7 100
ACVRL1 ACVRL1 78.9 100
COQ8A ADCK3 94.5 100
COQ8B ADCK4 93.2 100
AKT1 AKT1 90.9 100
AKT2 AKT2 88.4 100
AKT3 AKT3 95.6 100
ALK ALK(L1196M) 99.6 100
PRKAA1 AMPK-alpha1 77.0 100
PRKAA2 AMPK-alpha2 82.7 100
ANKK1 ANKK1 84.5 100
NUAK1 ARK5 100.0 100
MAP3K5 ASK1 100.0 100
MAP3K6 ASK2 100.0 100
AURKA AURKA 75.9 100
AURKB AURKB 98.8 100
AURKC AURKC 100.0 100
AXL AXL 80.5 100
BMP2K BIKE 94.7 100
BLK BLK 100.0 100
BMPR1A BMPR1A 97.2 100
BMPR1B BMPR1B 72.3 100
BMPR2 BMPR2 89.4 100
BMX BMX 76.7 100
BRAF BRAF(V600E) 100.0 100
PTK6 BRK 99.5 100
BRSK1 BRSK1 84.0 100
BRSK2 BRSK2 97.5 100
BTK BTK 100.0 100
BUB1 BUB1 99.8 100
CAMK1 CAMK1 60.4 100
PNCK CAMK1B 83.6 100
CAMK1D CAMK1D 71.6 100
CAMK1G CAMK1G 100.0 100
CAMK2A CAMK2A 95.0 100
CAMK2B CAMK2B 87.5 100
CAMK2D CAMK2D 89.1 100
CAMK2G CAMK2G 93.4 100
CAMK4 CAMK4 93.9 100
CAMKK1 CAMKK1 93.6 100
CAMKK2 CAMKK2 89.0 100
CASK CASK 86.6 100
CDK11B CDC2L1 93.2 100
CDK11A CDC2L2 89.9 100
CDK13 CDC2L5 59.0 100
CDK19 CDK11 90.7 100
CDK2 CDK2 99.0 100
CDK3 CDK3 92.4 100
CDK4 CDK4-cyclinD3 86.2 100
CDK5 CDK5 95.6 100
CDK7 CDK7 70.1 100
CDK8 CDK8 76.7 100
CDK9 CDK9 85.5 100
CDKL1 CDKL1 77.4 100
CDKL2 CDKL2 75.6 100
CDKL3 CDKL3 81.2 100
CDKL5 CDKL5 100.0 100
CHEK1 CHEK1 86.0 100
CHEK2 CHEK2 100.0 100
CIT CIT 69.9 100
CLK1 CLK1 96.2 100
CLK2 CLK2 91.0 100
CLK3 CLK3 87.7 100
CLK4 CLK4 93.3 100
CSF1R CSF1R-autoinhibited 92.9 100
CSK CSK 77.9 100
CSNK1A1 CSNK1A1 67.0 100
CSNK1A1L CSNK1A1L 88.4 100
CSNK1D CSNK1D 100.0 100
CSNK1E CSNK1E 98.7 100
CSNK1G1 CSNK1G1 91.1 100
CSNK1G2 CSNK1G2 77.6 100
CSNK1G3 CSNK1G3 93.7 100
CSNK2A1 CSNK2A1 74.2 100
CSNK2A2 CSNK2A2 82.4 100
MATK CTK 80.4 100
DAPK1 DAPK1 94.1 100
DAPK2 DAPK2 75.8 100
DAPK3 DAPK3 78.1 100
DCLK1 DCAMKL1 73.6 100
DCLK2 DCAMKL2 90.6 100
DCLK3 DCAMKL3 83.5 100
DDR1 DDR1 0.1 100
DDR2 DDR2 1.8 100
MAP3K12 DLK 82.5 100
DMPK DMPK 95.6 100
CDC42BPG DMPK2 88.8 100
STK17A DRAK1 100.0 100
STK17B DRAK2 91.4 100
DYRK1A DYRK1A 82.8 100
DYRK1B DYRK1B 100.0 100
DYRK2 DYRK2 82.5 100
EGFR EGFR(T790M) 61.6 100
EIF2AK1 EIF2AK1 100.0 100
EPHA1 EPHA1 100.0 100
EPHA2 EPHA2 79.6 100
EPHA3 EPHA3 89.8 100
EPHA4 EPHA4 100.0 100
EPHA5 EPHA5 92.4 100
EPHA6 EPHA6 82.6 100
EPHA7 EPHA7 92.0 100
EPHA8 EPHA8 83.5 100
EPHB1 EPHB1 100.0 100
EPHB2 EPHB2 71.4 100
EPHB3 EPHB3 100.0 100
EPHB4 EPHB4 99.6 100
EPHB6 EPHB6 3.0 100
ERBB2 ERBB2 84.2 100
ERBB3 ERBB3 96.2 100
ERBB4 ERBB4 96.3 100
MAPK3 ERK1 95.2 100
MAPK1 ERK2 88.1 100
MAPK6 ERK3 85.8 100
MAPK4 ERK4 86.3 100
MAPK7 ERK5 100.0 100
MAPK15 ERK8 94.1 100
ERN1 ERN1 68.3 100
PTK2 FAK 100.0 100
FER FER 100.0 100
FES FES 84.6 100
FGFR1 FGFR1 85.5 100
FGFR2 FGFR2 84.3 100
FGFR3 FGFR3(G697C) 100.0 100
FGFR4 FGFR4 99.4 100
FGR FGR 84.9 100
FLT1 FLT1 91.5 100
FLT3 FLT3-autoinhibited 84.1 100
FLT4 FLT4 77.6 100
FRK FRK 59.1 100
FYN FYN 97.5 100
GAK GAK 83.3 100
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 100
GRK1 GRK1 71.2 100
GRK2 GRK2 91.8 100
GRK3 GRK3 90.6 100
GRK4 GRK4 100.0 100
GRK7 GRK7 65.6 100
GSK3A GSK3A 100.0 100
GSK3B GSK3B 85.9 100
HASPIN HASPIN 64.0 100
HCK HCK 72.1 100
HIPK1 HIPK1 61.6 100
HIPK2 HIPK2 86.2 100
HIPK3 HIPK3 80.7 100
HIPK4 HIPK4 95.6 100
MAP4K1 HPK1 100.0 100
HUNK HUNK 83.0 100
CILK1 ICK 74.1 100
IGF1R IGF1R 84.7 100
CHUK IKK-alpha 100.0 100
IKBKB IKK-beta 100.0 100
IKBKE IKK-epsilon 59.9 100
INSR INSR 69.0 100
INSRR INSRR 91.8 100
IRAK1 IRAK1 87.3 100
IRAK3 IRAK3 75.2 100
IRAK4 IRAK4 100.0 100
ITK ITK 84.9 100
JAK1 JAK1(JH2domain-pseudokinase) 93.1 100
JAK2 JAK2(JH1domain-catalytic) 81.8 100
JAK3 JAK3(JH1domain-catalytic) 95.3 100
MAPK8 JNK1 76.8 100
MAPK9 JNK2 66.1 100
MAPK10 JNK3 100.0 100
KIT KIT-autoinhibited 76.8 100
LATS1 LATS1 83.9 100
LATS2 LATS2 73.2 100
LCK LCK 41.6 100
LIMK1 LIMK1 83.6 100
LIMK2 LIMK2 89.0 100
STK11 LKB1 75.9 100
STK10 LOK 1.8 100
LRRK2 LRRK2(G2019S) 73.9 100
LTK LTK 32.8 100
LYN LYN 46.0 100
MAP3K13 LZK 97.9 100
MAK MAK 77.2 100
MAP3K1 MAP3K1 78.3 100
MAP3K15 MAP3K15 48.8 100
MAP3K2 MAP3K2 86.4 100
MAP3K3 MAP3K3 67.3 100
MAP3K4 MAP3K4 98.1 100
MAP4K2 MAP4K2 53.1 100
MAP4K3 MAP4K3 89.6 100
MAP4K4 MAP4K4 95.1 100
MAP4K5 MAP4K5 83.4 100
MAPKAPK2 MAPKAPK2 100.0 100
MAPKAPK5 MAPKAPK5 91.7 100
MARK1 MARK1 96.7 100
MARK2 MARK2 100.0 100
MARK3 MARK3 85.1 100
MARK4 MARK4 92.4 100
MAST1 MAST1 100.0 100
MAP2K1 MEK1 76.2 100
MAP2K2 MEK2 74.4 100
MAP2K3 MEK3 81.9 100
MAP2K4 MEK4 74.7 100
MAP2K5 MEK5 91.8 100
MAP2K6 MEK6 100.0 100
MELK MELK 100.0 100
MERTK MERTK 83.6 100
MET MET(Y1235D) 93.4 100
MINK1 MINK 88.9 100
MAP2K7 MKK7 70.8 100
MKNK1 MKNK1 83.8 100
MKNK2 MKNK2 95.0 100
MYLK3 MLCK 100.0 100
MAP3K9 MLK1 79.5 100
MAP3K10 MLK2 100.0 100
MAP3K11 MLK3 100.0 100
CDC42BPA MRCKA 100.0 100
CDC42BPB MRCKB 95.5 100
STK4 MST1 88.5 100
MST1R MST1R 75.6 100
STK3 MST2 85.4 100
STK24 MST3 75.9 100
STK26 MST4 81.8 100
MTOR MTOR 70.1 100
MUSK MUSK 78.6 100
MYLK MYLK 57.7 100
MYLK2 MYLK2 100.0 100
MYLK4 MYLK4 100.0 100
MYO3A MYO3A 94.9 100
MYO3B MYO3B 82.4 100
STK38 NDR1 80.4 100
STK38L NDR2 98.9 100
NEK1 NEK1 100.0 100
NEK10 NEK10 100.0 100
NEK11 NEK11 86.1 100
NEK2 NEK2 98.6 100
NEK3 NEK3 70.7 100
NEK4 NEK4 90.2 100
NEK5 NEK5 87.8 100
NEK6 NEK6 93.9 100
NEK7 NEK7 75.5 100
NEK9 NEK9 72.2 100
MAP3K14 NIK 100.0 100
NIM1K NIM1 98.9 100
NLK NLK 100.0 100
OXSR1 OSR1 87.0 100
MAPK14 p38-alpha 0.0 100
MAPK11 p38-beta 93.4 100
MAPK13 p38-delta 65.6 100
MAPK12 p38-gamma 61.2 100
PAK1 PAK1 82.2 100
PAK2 PAK2 89.8 100
PAK3 PAK3 26.1 100
PAK4 PAK4 70.4 100
PAK6 PAK6 70.1 100
PAK5 PAK7 83.5 100
CDK16 PCTK1 92.5 100
CDK17 PCTK2 99.3 100
CDK18 PCTK3 98.4 100
PDGFRA PDGFRA 67.4 100
PDGFRB PDGFRB 74.8 100
PDPK1 PDPK1 100.0 100
CDPK1 PFCDPK1(P.falciparum) 88.9 100
PK5 PFPK5(P.falciparum) 90.9 100
CDK15 PFTAIRE2 76.0 100
CDK14 PFTK1 100.0 100
PHKG1 PHKG1 80.1 100
PHKG2 PHKG2 78.3 100
PIK3C2B PIK3C2B 93.4 100
PIK3C2G PIK3C2G 60.7 100
PIK3CA PIK3CA(Q546K) 100.0 100
PIK3CB PIK3CB 89.1 100
PIK3CD PIK3CD 76.9 100
PIK3CG PIK3CG 98.5 100
PI4KB PIK4CB 64.7 100
PIKFYVE PIKFYVE 74.9 100
PIM1 PIM1 92.0 100
PIM2 PIM2 100.0 100
PIM3 PIM3 83.1 100
PIP5K1A PIP5K1A 95.0 100
PIP5K1C PIP5K1C 70.2 100
PIP4K2B PIP5K2B 52.2 100
PIP4K2C PIP5K2C 89.9 100
PRKACA PKAC-alpha 95.6 100
PRKACB PKAC-beta 100.0 100
PKMYT1 PKMYT1 100.0 100
PKN1 PKN1 96.7 100
PKN2 PKN2 100.0 100
PKNB PKNB(M.tuberculosis) 62.5 100
PLK1 PLK1 100.0 100
PLK2 PLK2 83.3 100
PLK3 PLK3 81.8 100
PLK4 PLK4 64.1 100
PRKCD PRKCD 93.1 100
PRKCE PRKCE 100.0 100
PRKCH PRKCH 99.5 100
PRKCI PRKCI 100.0 100
PRKCQ PRKCQ 100.0 100
PRKD1 PRKD1 81.2 100
PRKD2 PRKD2 100.0 100
PRKD3 PRKD3 97.0 100
PRKG1 PRKG1 100.0 100
PRKG2 PRKG2 82.7 100
EIF2AK2 PRKR 96.4 100
PRKX PRKX 68.5 100
PRPF4B PRP4 80.6 100
PTK2B PYK2 81.4 100
SIK3 QSK 75.3 100
RAF1 RAF1 83.8 100
RET RET(V804M) 94.5 100
RIOK1 RIOK1 100.0 100
RIOK2 RIOK2 74.2 100
RIOK3 RIOK3 100.0 100
RIPK1 RIPK1 91.5 100
RIPK2 RIPK2 84.5 100
RIPK4 RIPK4 62.9 100
DSTYK RIPK5 71.1 100
ROCK1 ROCK1 74.9 100
ROCK2 ROCK2 66.2 100
ROS1 ROS1 100.0 100
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 79.3 100
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 65.1 100
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 65.1 100
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 74.9 100
RPS6KB1 S6K1 93.0 100
SBK1 SBK1 82.2 100
SGK1 SGK 100.0 100
SBK3 SgK110 100.0 100
SGK2 SGK2 100.0 100
SGK3 SGK3 81.5 100
SIK1 SIK 86.3 100
SIK2 SIK2 94.2 100
SLK SLK 48.5 100
NUAK2 SNARK 86.1 100
SNRK SNRK 100.0 100
SRC SRC 92.6 100
SRMS SRMS 67.4 100
SRPK1 SRPK1 67.4 100
SRPK2 SRPK2 60.1 100
SRPK3 SRPK3 100.0 100
STK16 STK16 64.3 100
STK33 STK33 100.0 100
STK35 STK35 92.0 100
STK36 STK36 80.8 100
STK39 STK39 64.6 100
SYK SYK 100.0 100
MAP3K7 TAK1 66.2 100
TAOK1 TAOK1 45.2 100
TAOK2 TAOK2 48.2 100
TAOK3 TAOK3 47.1 100
TBK1 TBK1 62.8 100
TEC TEC 88.4 100
TESK1 TESK1 85.1 100
TGFBR1 TGFBR1 98.2 100
TGFBR2 TGFBR2 78.6 100
TIE1 TIE1 15.9 100
TEK TIE2 3.1 100
TLK1 TLK1 89.1 100
TLK2 TLK2 100.0 100
TNIK TNIK 97.4 100
TNK1 TNK1 87.6 100
TNK2 TNK2 83.6 100
TNNI3K TNNI3K 85.8 100
NTRK1 TRKA 74.8 100
NTRK2 TRKB 54.8 100
NTRK3 TRKC 60.4 100
TRPM6 TRPM6 80.2 100
TSSK1B TSSK1B 100.0 100
TSSK3 TSSK3 76.9 100
TTK TTK 72.0 100
TXK TXK 98.3 100
TYK2 TYK2(JH2domain-pseudokinase) 87.3 100
TYRO3 TYRO3 72.4 100
ULK1 ULK1 100.0 100
ULK2 ULK2 100.0 100
ULK3 ULK3 100.0 100
KDR VEGFR2 76.2 100
PIK3C3 VPS34 84.9 100
VRK2 VRK2 79.8 100
WEE1 WEE1 100.0 100
WEE2 WEE2 77.4 100
WNK1 WNK1 97.3 100
WNK2 WNK2 100.0 100
WNK3 WNK3 61.9 100
WNK4 WNK4 100.0 100
STK32A YANK1 100.0 100
STK32B YANK2 94.3 100
STK32C YANK3 83.4 100
YES1 YES 70.7 100
STK25 YSK1 79.1 100
MAP3K19 YSK4 99.5 100
MAP3K20 ZAK 97.5 100
ZAP70 ZAP70 79.9 100

BAY-309


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 73.6 1000
ABL2 ABL2 100.0 1000
ACVR1 ACVR1 100.0 1000
ACVR1B ACVR1B 100.0 1000
ACVR2A ACVR2A 100.0 1000
ACVR2B ACVR2B 100.0 1000
ACVRL1 ACVRL1 100.0 1000
COQ8A ADCK3 82.8 1000
COQ8B ADCK4 100.0 1000
AKT1 AKT1 100.0 1000
AKT2 AKT2 82.5 1000
AKT3 AKT3 100.0 1000
ALK ALK(L1196M) 100.0 1000
PRKAA1 AMPK-alpha1 100.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 100.0 1000
NUAK1 ARK5 51.3 1000
MAP3K5 ASK1 100.0 1000
MAP3K6 ASK2 62.7 1000
AURKA AURKA 84.9 1000
AURKB AURKB 82.0 1000
AURKC AURKC 86.7 1000
AXL AXL 100.0 1000
BMP2K BIKE 65.9 1000
BLK BLK 100.0 1000
BMPR1A BMPR1A 94.4 1000
BMPR1B BMPR1B 100.0 1000
BMPR2 BMPR2 59.3 1000
BMX BMX 100.0 1000
BRAF BRAF(V600E) 24.4 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 100.0 1000
BRSK2 BRSK2 100.0 1000
BTK BTK 83.8 1000
BUB1 BUB1 100.0 1000
CAMK1 CAMK1 77.9 1000
PNCK CAMK1B 100.0 1000
CAMK1D CAMK1D 94.9 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 100.0 1000
CAMK2B CAMK2B 100.0 1000
CAMK2D CAMK2D 80.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 80.5 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 99.6 1000
CASK CASK 68.1 1000
CDK11B CDC2L1 100.0 1000
CDK11A CDC2L2 95.4 1000
CDK13 CDC2L5 64.2 1000
CDK19 CDK11 84.1 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 100.0 1000
CDK7 CDK7 100.0 1000
CDK8 CDK8 86.2 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 84.5 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 100.0 1000
CDKL5 CDKL5 100.0 1000
CHEK1 CHEK1 72.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 60.7 1000
CLK1 CLK1 100.0 1000
CLK2 CLK2 100.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 100.0 1000
CSF1R CSF1R-autoinhibited 89.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 50.7 1000
CSNK1A1L CSNK1A1L 100.0 1000
CSNK1D CSNK1D 100.0 1000
CSNK1E CSNK1E 75.7 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 95.4 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 66.7 1000
CSNK2A2 CSNK2A2 100.0 1000
MATK CTK 100.0 1000
DAPK1 DAPK1 100.0 1000
DAPK2 DAPK2 100.0 1000
DAPK3 DAPK3 100.0 1000
DCLK1 DCAMKL1 66.2 1000
DCLK2 DCAMKL2 100.0 1000
DCLK3 DCAMKL3 100.0 1000
DDR1 DDR1 0.0 1000 = 2.1
DDR2 DDR2 18.2 1000 = 63.0
MAP3K12 DLK 67.7 1000
DMPK DMPK 100.0 1000
CDC42BPG DMPK2 100.0 1000
STK17A DRAK1 100.0 1000
STK17B DRAK2 100.0 1000
DYRK1A DYRK1A 100.0 1000
DYRK1B DYRK1B 61.2 1000
DYRK2 DYRK2 100.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 100.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 100.0 1000
EPHA4 EPHA4 76.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 91.2 1000
EPHA8 EPHA8 100.0 1000
EPHB1 EPHB1 100.0 1000
EPHB2 EPHB2 100.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 100.0 1000
ERBB2 ERBB2 100.0 1000
ERBB3 ERBB3 49.4 1000
ERBB4 ERBB4 98.1 1000
MAPK3 ERK1 86.8 1000
MAPK1 ERK2 61.7 1000
MAPK6 ERK3 100.0 1000
MAPK4 ERK4 50.4 1000
MAPK7 ERK5 90.0 1000
MAPK15 ERK8 100.0 1000
ERN1 ERN1 99.2 1000
PTK2 FAK 96.4 1000
FER FER 59.4 1000
FES FES 100.0 1000
FGFR1 FGFR1 100.0 1000
FGFR2 FGFR2 81.7 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 100.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 100.0 1000
FLT3 FLT3-autoinhibited 100.0 1000
FLT4 FLT4 82.3 1000
FRK FRK 100.0 1000
FYN FYN 81.3 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 1000
GRK1 GRK1 50.4 1000
GRK2 GRK2 74.5 1000
GRK3 GRK3 74.8 1000
GRK4 GRK4 100.0 1000
GRK7 GRK7 100.0 1000
GSK3A GSK3A 100.0 1000
GSK3B GSK3B 85.4 1000
HASPIN HASPIN 70.9 1000
HCK HCK 98.7 1000
HIPK1 HIPK1 49.1 1000
HIPK2 HIPK2 85.0 1000
HIPK3 HIPK3 88.8 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 82.1 1000
HUNK HUNK 77.6 1000
CILK1 ICK 64.2 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 71.1 1000
IKBKB IKK-beta 65.5 1000
IKBKE IKK-epsilon 100.0 1000
INSR INSR 100.0 1000
INSRR INSRR 100.0 1000
IRAK1 IRAK1 96.0 1000
IRAK3 IRAK3 100.0 1000
IRAK4 IRAK4 98.4 1000
ITK ITK 100.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 28.7 1000
JAK2 JAK2(JH1domain-catalytic) 85.3 1000
JAK3 JAK3(JH1domain-catalytic) 96.9 1000
MAPK8 JNK1 55.9 1000
MAPK9 JNK2 76.9 1000
MAPK10 JNK3 64.9 1000
KIT KIT-autoinhibited 70.3 1000
LATS1 LATS1 100.0 1000
LATS2 LATS2 100.0 1000
LCK LCK 96.6 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 95.3 1000
STK11 LKB1 100.0 1000
STK10 LOK 26.8 1000
LRRK2 LRRK2(G2019S) 81.3 1000
LTK LTK 100.0 1000
LYN LYN 100.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 90.0 1000
MAP3K15 MAP3K15 100.0 1000
MAP3K2 MAP3K2 52.7 1000
MAP3K3 MAP3K3 87.9 1000
MAP3K4 MAP3K4 53.6 1000
MAP4K2 MAP4K2 100.0 1000
MAP4K3 MAP4K3 100.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 100.0 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 100.0 1000
MARK1 MARK1 100.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 100.0 1000
MARK4 MARK4 84.8 1000
MAST1 MAST1 100.0 1000
MAP2K1 MEK1 100.0 1000
MAP2K2 MEK2 93.3 1000
MAP2K3 MEK3 62.1 1000
MAP2K4 MEK4 76.0 1000
MAP2K5 MEK5 35.9 1000
MAP2K6 MEK6 100.0 1000
MELK MELK 100.0 1000
MERTK MERTK 100.0 1000
MET MET(Y1235D) 100.0 1000
MINK1 MINK 82.0 1000
MAP2K7 MKK7 89.7 1000
MKNK1 MKNK1 100.0 1000
MKNK2 MKNK2 85.2 1000
MYLK3 MLCK 100.0 1000
MAP3K9 MLK1 77.7 1000
MAP3K10 MLK2 100.0 1000
MAP3K11 MLK3 100.0 1000
CDC42BPA MRCKA 88.5 1000
CDC42BPB MRCKB 100.0 1000
STK4 MST1 100.0 1000
MST1R MST1R 71.0 1000
STK3 MST2 100.0 1000
STK24 MST3 100.0 1000
STK26 MST4 100.0 1000
MTOR MTOR 99.2 1000
MUSK MUSK 82.0 1000
MYLK MYLK 91.8 1000
MYLK2 MYLK2 100.0 1000
MYLK4 MYLK4 91.4 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 73.8 1000
STK38 NDR1 92.3 1000
STK38L NDR2 100.0 1000
NEK1 NEK1 100.0 1000
NEK10 NEK10 37.6 1000
NEK11 NEK11 57.5 1000
NEK2 NEK2 90.8 1000
NEK3 NEK3 50.5 1000
NEK4 NEK4 92.9 1000
NEK5 NEK5 86.8 1000
NEK6 NEK6 97.0 1000
NEK7 NEK7 100.0 1000
NEK9 NEK9 100.0 1000
MAP3K14 NIK 73.8 1000
NIM1K NIM1 100.0 1000
NLK NLK 100.0 1000
OXSR1 OSR1 100.0 1000
MAPK14 p38-alpha 100.0 1000
MAPK11 p38-beta 98.1 1000
MAPK13 p38-delta 79.6 1000
MAPK12 p38-gamma 41.7 1000
PAK1 PAK1 90.9 1000
PAK2 PAK2 100.0 1000
PAK3 PAK3 100.0 1000
PAK4 PAK4 91.8 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 100.0 1000
CDK17 PCTK2 83.8 1000
CDK18 PCTK3 80.6 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 100.0 1000
PDPK1 PDPK1 92.0 1000
CDPK1 PFCDPK1(P.falciparum) 95.1 1000
PK5 PFPK5(P.falciparum) 71.8 1000
CDK15 PFTAIRE2 59.9 1000
CDK14 PFTK1 93.8 1000
PHKG1 PHKG1 100.0 1000
PHKG2 PHKG2 100.0 1000
PIK3C2B PIK3C2B 100.0 1000
PIK3C2G PIK3C2G 100.0 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 100.0 1000
PIK3CD PIK3CD 100.0 1000
PIK3CG PIK3CG 100.0 1000
PI4KB PIK4CB 78.6 1000
PIKFYVE PIKFYVE 100.0 1000
PIM1 PIM1 95.6 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 100.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 100.0 1000
PIP4K2C PIP5K2C 99.1 1000
PRKACA PKAC-alpha 100.0 1000
PRKACB PKAC-beta 100.0 1000
PKMYT1 PKMYT1 100.0 1000
PKN1 PKN1 100.0 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 63.7 1000
PLK1 PLK1 95.3 1000
PLK2 PLK2 100.0 1000
PLK3 PLK3 69.4 1000
PLK4 PLK4 96.9 1000
PRKCD PRKCD 95.8 1000
PRKCE PRKCE 91.2 1000
PRKCH PRKCH 100.0 1000
PRKCI PRKCI 80.4 1000
PRKCQ PRKCQ 60.3 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 100.0 1000
PRKD3 PRKD3 100.0 1000
PRKG1 PRKG1 100.0 1000
PRKG2 PRKG2 100.0 1000
EIF2AK2 PRKR 72.7 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 99.7 1000
PTK2B PYK2 100.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 29.4 1000
RET RET(V804M) 74.2 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 49.7 1000
RIOK3 RIOK3 85.9 1000
RIPK1 RIPK1 80.7 1000
RIPK2 RIPK2 88.6 1000
RIPK4 RIPK4 34.1 1000
DSTYK RIPK5 72.8 1000
ROCK1 ROCK1 74.8 1000
ROCK2 ROCK2 87.6 1000
ROS1 ROS1 92.8 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 89.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KB1 S6K1 66.2 1000
SBK1 SBK1 100.0 1000
SGK1 SGK 81.3 1000
SBK3 SgK110 100.0 1000
SGK2 SGK2 100.0 1000
SGK3 SGK3 72.1 1000
SIK1 SIK 100.0 1000
SIK2 SIK2 100.0 1000
SLK SLK 95.2 1000
NUAK2 SNARK 100.0 1000
SNRK SNRK 100.0 1000
SRC SRC 100.0 1000
SRMS SRMS 86.9 1000
SRPK1 SRPK1 100.0 1000
SRPK2 SRPK2 100.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 53.9 1000
STK33 STK33 87.8 1000
STK35 STK35 100.0 1000
STK36 STK36 93.1 1000
STK39 STK39 100.0 1000
SYK SYK 95.5 1000
MAP3K7 TAK1 100.0 1000
TAOK1 TAOK1 100.0 1000
TAOK2 TAOK2 91.3 1000
TAOK3 TAOK3 100.0 1000
TBK1 TBK1 49.7 1000
TEC TEC 100.0 1000
TESK1 TESK1 91.7 1000
TGFBR1 TGFBR1 74.3 1000
TGFBR2 TGFBR2 94.5 1000
TIE1 TIE1 34.2 1000
TEK TIE2 84.2 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 94.3 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 95.0 1000
TNK2 TNK2 100.0 1000
TNNI3K TNNI3K 100.0 1000
NTRK1 TRKA 40.2 1000
NTRK2 TRKB 40.0 1000
NTRK3 TRKC 27.2 1000
TRPM6 TRPM6 97.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 100.0 1000
TTK TTK 44.8 1000
TXK TXK 56.2 1000
TYK2 TYK2(JH2domain-pseudokinase) 100.0 1000
TYRO3 TYRO3 88.4 1000
ULK1 ULK1 100.0 1000
ULK2 ULK2 73.7 1000
ULK3 ULK3 75.2 1000
KDR VEGFR2 68.3 1000
PIK3C3 VPS34 76.6 1000
VRK2 VRK2 100.0 1000
WEE1 WEE1 100.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 100.0 1000
WNK2 WNK2 100.0 1000
WNK3 WNK3 100.0 1000
WNK4 WNK4 100.0 1000
STK32A YANK1 100.0 1000
STK32B YANK2 100.0 1000
STK32C YANK3 75.8 1000
YES1 YES 100.0 1000
STK25 YSK1 59.5 1000
MAP3K19 YSK4 100.0 1000
MAP3K20 ZAK 84.4 1000
ZAP70 ZAP70 100.0 1000

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