Selectivity data for probe BAY-985 and control BAY-440


Jump to control PDSP data

BAY-985


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT2C HTR2C 11.40
5-HT3 HTR3A 31.94
5-HT5A HTR5A 11.90
Beta2 ADRB2 33.33
DOR OPRD1 29.03
H1 HRH1 35.00
H2 HRH2 3.55
H3 HRH3 -3.83
M1 CHRM1 15.13
M2 CHRM2 32.87
M3 CHRM3 -8.40
M4 CHRM4 24.70
M5 CHRM5 18.71
SERT SLC6A4 21.55
Alpha1A ADRA1A 11.94
Alpha1B ADRA1B 2.95
Alpha1D ADRA1D 20.24
Alpha2A ADRA2A 24.18
Alpha2B ADRA2B 24.70
Sigma 1 SIGMAR1 3.18
Sigma 2 TMEM97 54.15 1155.57 average (n=2) 5.95
5-HT1A HTR1A 6.47
5-HT1B HTR1B 11.52
5-HT1D HTR1D 23.22
5-HT1E HTR1E 13.58
5-HT2A HTR2A -11.09
5-HT2B HTR2B 60.04 1305.20 average (n=2) 5.89
5-HT6 HTR6 -4.38
5-HT7A HTR7 16.56
D1 DRD1 1.63
D2 DRD2 5.66
D3 DRD3 35.48
D4 DRD4 8.17
D5 DRD5 10.19
DAT SLC6A3 30.51
H4 HRH4 -0.75
KOR OPRK1 4.24
MOR OPRM1 25.96
NET SLC6A2 -20.01
GABAA/BZP 22.99
GABAA 5.57
GABA/PBR -2.73
Beta1 ADRB1 24.31
Beta3 ADRB3 30.43
Alpha2C ADRA2C 9.82

BAY-440


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
D4 DRD4 7.18
D5 DRD5 -9.93
H4 HRH4 -2.29
KOR OPRK1 33.68
MOR OPRM1 14.08
NET SLC6A2 -29.45
5-HT2C HTR2C 0.02
5-HT3 HTR3A 35.60
5-HT5A HTR5A 23.63
Beta2 ADRB2 12.63
D1 DRD1 22.96
DOR OPRD1 2.06
H1 HRH1 26.36
H2 HRH2 32.65
H3 HRH3 4.68
M1 CHRM1 32.14
M2 CHRM2 35.14
M3 CHRM3 23.90
M4 CHRM4 4.83
M5 CHRM5 12.40
SERT SLC6A4 9.90
Alpha1A ADRA1A 12.84
Alpha1B ADRA1B 4.51
Alpha1D ADRA1D 20.82
Alpha2A ADRA2A 15.74
Alpha2B ADRA2B -2.22
Sigma 1 SIGMAR1 13.90
Sigma 2 TMEM97 68.09 2194.58 average (n=2) 5.66
5-HT1A HTR1A 13.90
5-HT1B HTR1B 6.15
5-HT1D HTR1D 19.46
5-HT1E HTR1E 29.28
5-HT2A HTR2A -4.19
5-HT2B HTR2B 38.98
5-HT6 HTR6 12.38
5-HT7A HTR7 13.42
D2 DRD2 10.62
D3 DRD3 30.11
DAT SLC6A3 -19.00
Beta1 ADRB1 -6.20
Beta3 ADRB3 4.42
GABAA/BZP -22.23
GABA/PBR 13.87
Alpha2C ADRA2C 7.09
GABAA 13.96

Jump to PDSP top

Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
View assay details

Jump to control KinomeScan data

BAY-985


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 60.0 100
ABL1 ABL1-phosphorylated 85.0 100
ABL2 ABL2 100.0 100
ACVR1 ACVR1 100.0 100
ACVR1B ACVR1B 94.0 100
ACVR2A ACVR2A 100.0 100
ACVR2B ACVR2B 81.0 100
ACVRL1 ACVRL1 100.0 100
COQ8A ADCK3 100.0 100
COQ8B ADCK4 79.0 100
AKT1 AKT1 100.0 100
AKT2 AKT2 100.0 100
AKT3 AKT3 100.0 100
ALK ALK(L1196M) 100.0 100
PRKAA1 AMPK-alpha1 100.0 100
PRKAA2 AMPK-alpha2 100.0 100
ANKK1 ANKK1 99.0 100
NUAK1 ARK5 93.0 100
MAP3K5 ASK1 100.0 100
MAP3K6 ASK2 100.0 100
AURKA AURKA 100.0 100
AURKB AURKB 100.0 100
AURKC AURKC 100.0 100
AXL AXL 100.0 100
BMP2K BIKE 100.0 100
BLK BLK 79.0 100
BMPR1A BMPR1A 97.0 100
BMPR1B BMPR1B 86.0 100
BMPR2 BMPR2 100.0 100
BMX BMX 100.0 100
BRAF BRAF(V600E) 100.0 100
PTK6 BRK 85.0 100
BRSK1 BRSK1 100.0 100
BRSK2 BRSK2 100.0 100
BTK BTK 100.0 100
BUB1 BUB1 95.0 100
CAMK1 CAMK1 88.0 100
PNCK CAMK1B 100.0 100
CAMK1D CAMK1D 95.0 100
CAMK1G CAMK1G 76.0 100
CAMK2A CAMK2A 99.0 100
CAMK2B CAMK2B 92.0 100
CAMK2D CAMK2D 70.0 100
CAMK2G CAMK2G 77.0 100
CAMK4 CAMK4 100.0 100
CAMKK1 CAMKK1 89.0 100
CAMKK2 CAMKK2 77.0 100
CASK CASK 100.0 100
CDK11B CDC2L1 100.0 100
CDK11A CDC2L2 84.0 100
CDK13 CDC2L5 100.0 100
CDK19 CDK11 93.0 100
CDK2 CDK2 100.0 100
CDK3 CDK3 100.0 100
CDK4 CDK4-cyclinD3 89.0 100
CDK5 CDK5 86.0 100
CDK7 CDK7 93.0 100
CDK8 CDK8 96.0 100
CDK9 CDK9 100.0 100
CDKL1 CDKL1 100.0 100
CDKL2 CDKL2 100.0 100
CDKL3 CDKL3 86.0 100
CDKL5 CDKL5 100.0 100
CHEK1 CHEK1 87.0 100
CHEK2 CHEK2 84.0 100
CIT CIT 78.0 100
CLK1 CLK1 90.0 100
CLK2 CLK2 65.0 100
CLK3 CLK3 100.0 100
CLK4 CLK4 82.0 100
CSF1R CSF1R-autoinhibited 90.0 100
CSK CSK 100.0 100
CSNK1A1 CSNK1A1 100.0 100
CSNK1A1L CSNK1A1L 94.0 100
CSNK1D CSNK1D 89.0 100
CSNK1E CSNK1E 100.0 100
CSNK1G1 CSNK1G1 100.0 100
CSNK1G2 CSNK1G2 96.0 100
CSNK1G3 CSNK1G3 100.0 100
CSNK2A1 CSNK2A1 100.0 100
CSNK2A2 CSNK2A2 100.0 100
MATK CTK 95.0 100
DAPK1 DAPK1 93.0 100
DAPK2 DAPK2 74.0 100
DAPK3 DAPK3 90.0 100
DCLK1 DCAMKL1 96.0 100
DCLK2 DCAMKL2 85.0 100
DCLK3 DCAMKL3 100.0 100
DDR1 DDR1 100.0 100
DDR2 DDR2 100.0 100
MAP3K12 DLK 100.0 100
DMPK DMPK 100.0 100
CDC42BPG DMPK2 79.0 100
STK17A DRAK1 40.0 100
STK17B DRAK2 100.0 100
DYRK1A DYRK1A 98.0 100
DYRK1B DYRK1B 84.0 100
DYRK2 DYRK2 87.0 100
EGFR EGFR(T790M) 100.0 100
EIF2AK1 EIF2AK1 100.0 100
EPHA1 EPHA1 99.0 100
EPHA2 EPHA2 100.0 100
EPHA3 EPHA3 100.0 100
EPHA4 EPHA4 98.0 100
EPHA5 EPHA5 81.0 100
EPHA6 EPHA6 93.0 100
EPHA7 EPHA7 100.0 100
EPHA8 EPHA8 100.0 100
EPHB1 EPHB1 98.0 100
EPHB2 EPHB2 93.0 100
EPHB3 EPHB3 93.0 100
EPHB4 EPHB4 100.0 100
EPHB6 EPHB6 100.0 100
ERBB2 ERBB2 100.0 100
ERBB3 ERBB3 88.0 100
ERBB4 ERBB4 96.0 100
MAPK3 ERK1 89.0 100
MAPK1 ERK2 78.0 100
MAPK6 ERK3 86.0 100
MAPK4 ERK4 100.0 100
MAPK7 ERK5 100.0 100
MAPK15 ERK8 100.0 100
ERN1 ERN1 86.0 100
PTK2 FAK 100.0 100
FER FER 100.0 100
FES FES 75.0 100
FGFR1 FGFR1 100.0 100
FGFR2 FGFR2 100.0 100
FGFR3 FGFR3(G697C) 100.0 100
FGFR4 FGFR4 98.0 100
FGR FGR 85.0 100
FLT1 FLT1 100.0 100
FLT3 FLT3-autoinhibited 95.0 100
FLT4 FLT4 92.0 100
FRK FRK 92.0 100
FYN FYN 79.0 100
GAK GAK 95.0 100
EIF2AK4 GCN2(Kin.Dom.2,S808G) 58.0 100
GRK1 GRK1 90.0 100
GRK2 GRK2 100.0 100
GRK3 GRK3 100.0 100
GRK4 GRK4 100.0 100
GRK7 GRK7 89.0 100
GSK3A GSK3A 100.0 100
GSK3B GSK3B 100.0 100
HASPIN HASPIN 100.0 100
HCK HCK 91.0 100
HIPK1 HIPK1 95.0 100
HIPK2 HIPK2 100.0 100
HIPK3 HIPK3 100.0 100
HIPK4 HIPK4 100.0 100
MAP4K1 HPK1 51.0 100
HUNK HUNK 95.0 100
CILK1 ICK 88.0 100
IGF1R IGF1R 98.0 100
CHUK IKK-alpha 95.0 100
IKBKB IKK-beta 99.0 100
IKBKE IKK-epsilon 9.9 100
INSR INSR 100.0 100
INSRR INSRR 100.0 100
IRAK1 IRAK1 100.0 100
IRAK3 IRAK3 76.0 100
IRAK4 IRAK4 100.0 100
ITK ITK 100.0 100
JAK1 JAK1(JH2domain-pseudokinase) 100.0 100
JAK2 JAK2(JH1domain-catalytic) 100.0 100
JAK3 JAK3(JH1domain-catalytic) 83.0 100
MAPK8 JNK1 98.0 100
MAPK9 JNK2 89.0 100
MAPK10 JNK3 81.0 100
KIT KIT-autoinhibited 100.0 100
LATS1 LATS1 100.0 100
LATS2 LATS2 80.0 100
LCK LCK 100.0 100
LIMK1 LIMK1 100.0 100
LIMK2 LIMK2 88.0 100
STK11 LKB1 100.0 100
STK10 LOK 86.0 100
LRRK2 LRRK2(G2019S) 100.0 100
LTK LTK 100.0 100
LYN LYN 97.0 100
MAP3K13 LZK 100.0 100
MAK MAK 100.0 100
MAP3K1 MAP3K1 100.0 100
MAP3K15 MAP3K15 96.0 100
MAP3K2 MAP3K2 100.0 100
MAP3K3 MAP3K3 100.0 100
MAP3K4 MAP3K4 96.0 100
MAP4K2 MAP4K2 100.0 100
MAP4K3 MAP4K3 100.0 100
MAP4K4 MAP4K4 91.0 100
MAP4K5 MAP4K5 96.0 100
MAPKAPK2 MAPKAPK2 100.0 100
MAPKAPK5 MAPKAPK5 86.0 100
MARK1 MARK1 100.0 100
MARK2 MARK2 100.0 100
MARK3 MARK3 100.0 100
MARK4 MARK4 100.0 100
MAST1 MAST1 100.0 100
MAP2K1 MEK1 99.0 100
MAP2K2 MEK2 100.0 100
MAP2K3 MEK3 97.0 100
MAP2K4 MEK4 100.0 100
MAP2K5 MEK5 8.5 100
MAP2K6 MEK6 96.0 100
MELK MELK 100.0 100
MERTK MERTK 97.0 100
MET MET(Y1235D) 100.0 100
MINK1 MINK 94.0 100
MAP2K7 MKK7 92.0 100
MKNK1 MKNK1 92.0 100
MKNK2 MKNK2 86.0 100
MYLK3 MLCK 100.0 100
MAP3K9 MLK1 100.0 100
MAP3K10 MLK2 100.0 100
MAP3K11 MLK3 92.0 100
CDC42BPA MRCKA 99.0 100
CDC42BPB MRCKB 100.0 100
STK4 MST1 100.0 100
MST1R MST1R 80.0 100
STK3 MST2 93.0 100
STK24 MST3 64.0 100
STK26 MST4 100.0 100
MTOR MTOR 75.0 100
MUSK MUSK 97.0 100
MYLK MYLK 100.0 100
MYLK2 MYLK2 92.0 100
MYLK4 MYLK4 100.0 100
MYO3A MYO3A 100.0 100
MYO3B MYO3B 100.0 100
STK38 NDR1 100.0 100
STK38L NDR2 65.0 100
NEK1 NEK1 93.0 100
NEK10 NEK10 100.0 100
NEK11 NEK11 96.0 100
NEK2 NEK2 100.0 100
NEK3 NEK3 100.0 100
NEK4 NEK4 100.0 100
NEK5 NEK5 100.0 100
NEK6 NEK6 83.0 100
NEK7 NEK7 100.0 100
NEK9 NEK9 100.0 100
MAP3K14 NIK 100.0 100
NIM1K NIM1 100.0 100
NLK NLK 88.0 100
OXSR1 OSR1 100.0 100
MAPK14 p38-alpha 100.0 100
MAPK11 p38-beta 89.0 100
MAPK13 p38-delta 80.0 100
MAPK12 p38-gamma 95.0 100
PAK1 PAK1 77.0 100
PAK2 PAK2 68.0 100
PAK3 PAK3 100.0 100
PAK4 PAK4 81.0 100
PAK6 PAK6 100.0 100
PAK5 PAK7 100.0 100
CDK16 PCTK1 100.0 100
CDK17 PCTK2 100.0 100
CDK18 PCTK3 89.0 100
PDGFRA PDGFRA 99.0 100
PDGFRB PDGFRB 82.0 100
PDPK1 PDPK1 76.0 100
CDPK1 PFCDPK1(P.falciparum) 100.0 100
PK5 PFPK5(P.falciparum) 100.0 100
CDK15 PFTAIRE2 100.0 100
CDK14 PFTK1 100.0 100
PHKG1 PHKG1 100.0 100
PHKG2 PHKG2 81.0 100
PIK3C2B PIK3C2B 97.0 100
PIK3C2G PIK3C2G 94.0 100
PIK3CA PIK3CA(Q546K) 45.0 100
PIK3CB PIK3CB 100.0 100
PIK3CD PIK3CD 100.0 100
PIK3CG PIK3CG 100.0 100
PI4KB PIK4CB 100.0 100
PIKFYVE PIKFYVE 100.0 100
PIM1 PIM1 79.0 100
PIM2 PIM2 100.0 100
PIM3 PIM3 87.0 100
PIP5K1A PIP5K1A 100.0 100
PIP5K1C PIP5K1C 89.0 100
PIP4K2B PIP5K2B 75.0 100
PIP4K2C PIP5K2C 96.0 100
PRKACA PKAC-alpha 100.0 100
PRKACB PKAC-beta 100.0 100
PKMYT1 PKMYT1 83.0 100
PKN1 PKN1 100.0 100
PKN2 PKN2 95.0 100
PKNB PKNB(M.tuberculosis) 91.0 100
PLK1 PLK1 100.0 100
PLK2 PLK2 100.0 100
PLK3 PLK3 100.0 100
PLK4 PLK4 96.0 100
PRKCD PRKCD 100.0 100
PRKCE PRKCE 96.0 100
PRKCH PRKCH 84.0 100
PRKCI PRKCI 100.0 100
PRKCQ PRKCQ 100.0 100
PRKD1 PRKD1 100.0 100
PRKD2 PRKD2 100.0 100
PRKD3 PRKD3 100.0 100
PRKG1 PRKG1 100.0 100
PRKG2 PRKG2 94.0 100
EIF2AK2 PRKR 100.0 100
PRKX PRKX 99.0 100
PRPF4B PRP4 80.0 100
PTK2B PYK2 91.0 100
SIK3 QSK 100.0 100
RAF1 RAF1 97.0 100
RET RET(V804M) 76.0 100
RIOK1 RIOK1 100.0 100
RIOK2 RIOK2 100.0 100
RIOK3 RIOK3 97.0 100
RIPK1 RIPK1 95.0 100
RIPK2 RIPK2 71.0 100
RIPK4 RIPK4 100.0 100
DSTYK RIPK5 100.0 100
ROCK1 ROCK1 100.0 100
ROCK2 ROCK2 100.0 100
ROS1 ROS1 100.0 100
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 94.0 100
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 61.0 100
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 82.0 100
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 89.0 100
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 56.0 100
RPS6KB1 S6K1 100.0 100
SBK1 SBK1 85.0 100
SGK1 SGK 94.0 100
SBK3 SgK110 100.0 100
SGK2 SGK2 100.0 100
SGK3 SGK3 100.0 100
SIK1 SIK 96.0 100
SIK2 SIK2 79.0 100
SLK SLK 99.0 100
NUAK2 SNARK 95.0 100
SNRK SNRK 100.0 100
SRC SRC 100.0 100
SRMS SRMS 97.0 100
SRPK1 SRPK1 85.0 100
SRPK2 SRPK2 100.0 100
SRPK3 SRPK3 100.0 100
STK16 STK16 86.0 100
STK33 STK33 100.0 100
STK35 STK35 100.0 100
STK36 STK36 97.0 100
STK39 STK39 100.0 100
SYK SYK 31.0 100
MAP3K7 TAK1 85.0 100
TAOK1 TAOK1 100.0 100
TAOK2 TAOK2 100.0 100
TAOK3 TAOK3 41.0 100
TBK1 TBK1 2.4 100
TEC TEC 100.0 100
TESK1 TESK1 98.0 100
TGFBR1 TGFBR1 85.0 100
TGFBR2 TGFBR2 98.0 100
TIE1 TIE1 85.0 100
TEK TIE2 99.0 100
TLK1 TLK1 76.0 100
TLK2 TLK2 99.0 100
TNIK TNIK 96.0 100
TNK1 TNK1 100.0 100
TNK2 TNK2 100.0 100
TNNI3K TNNI3K 59.0 100
NTRK1 TRKA 79.0 100
NTRK2 TRKB 100.0 100
NTRK3 TRKC 100.0 100
TRPM6 TRPM6 100.0 100
TSSK1B TSSK1B 100.0 100
TSSK3 TSSK3 74.0 100
TTK TTK 82.0 100
TXK TXK 96.0 100
TYK2 TYK2(JH2domain-pseudokinase) 100.0 100
TYRO3 TYRO3 96.0 100
ULK1 ULK1 95.0 100
ULK2 ULK2 100.0 100
ULK3 ULK3 90.0 100
KDR VEGFR2 100.0 100
PIK3C3 VPS34 100.0 100
VRK2 VRK2 94.0 100
WEE1 WEE1 96.0 100
WEE2 WEE2 98.0 100
WNK1 WNK1 100.0 100
WNK2 WNK2 92.0 100
WNK3 WNK3 100.0 100
WNK4 WNK4 80.0 100
STK32A YANK1 100.0 100
STK32B YANK2 100.0 100
STK32C YANK3 100.0 100
YES1 YES 92.0 100
STK25 YSK1 100.0 100
MAP3K19 YSK4 10.0 100
MAP3K20 ZAK 98.0 100
ZAP70 ZAP70 100.0 100

BAY-440


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
CIT CIT 100.0 1000
AAK1 AAK1 85.0 1000
ABL1 ABL1-phosphorylated 51.0 1000
ABL2 ABL2 71.0 1000
ACVR1 ACVR1 88.0 1000
ACVR1B ACVR1B 91.0 1000
ACVR2A ACVR2A 90.0 1000
ACVR2B ACVR2B 100.0 1000
ACVRL1 ACVRL1 94.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 90.0 1000
AKT1 AKT1 100.0 1000
AKT2 AKT2 95.0 1000
AKT3 AKT3 96.0 1000
ALK ALK(L1196M) 79.0 1000
PRKAA1 AMPK-alpha1 100.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 57.0 1000
NUAK1 ARK5 100.0 1000
MAP3K5 ASK1 100.0 1000
MAP3K6 ASK2 87.0 1000
AURKA AURKA 84.0 1000
AURKB AURKB 85.0 1000
AURKC AURKC 100.0 1000
AXL AXL 57.0 1000
BMP2K BIKE 100.0 1000
BLK BLK 82.0 1000
BMPR1A BMPR1A 95.0 1000
BMPR1B BMPR1B 59.0 1000
BMPR2 BMPR2 61.0 1000
BMX BMX 100.0 1000
BRAF BRAF(V600E) 84.0 1000
PTK6 BRK 86.0 1000
BRSK1 BRSK1 100.0 1000
BRSK2 BRSK2 100.0 1000
BTK BTK 80.0 1000
BUB1 BUB1 94.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 72.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 100.0 1000
CAMK2B CAMK2B 100.0 1000
CAMK2D CAMK2D 90.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 89.0 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 88.0 1000
CASK CASK 89.0 1000
CDK11B CDC2L1 100.0 1000
CDK11A CDC2L2 100.0 1000
CDK13 CDC2L5 84.0 1000
CDK19 CDK11 75.0 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 86.0 1000
CDK4 CDK4-cyclinD3 70.0 1000
CDK5 CDK5 100.0 1000
CDK7 CDK7 80.0 1000
CDK8 CDK8 90.0 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 96.0 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 86.0 1000
CDKL5 CDKL5 66.0 1000
CHEK1 CHEK1 97.0 1000
CHEK2 CHEK2 100.0 1000
CLK1 CLK1 71.0 1000
CLK2 CLK2 90.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 99.0 1000
CSF1R CSF1R-autoinhibited 50.0 1000
CSK CSK 84.0 1000
CSNK1A1 CSNK1A1 89.0 1000
CSNK1A1L CSNK1A1L 94.0 1000
CSNK1D CSNK1D 83.0 1000
CSNK1E CSNK1E 100.0 1000
CSNK1G1 CSNK1G1 76.0 1000
CSNK1G2 CSNK1G2 100.0 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 80.0 1000
CSNK2A2 CSNK2A2 78.0 1000
MATK CTK 69.0 1000
DAPK1 DAPK1 100.0 1000
DAPK2 DAPK2 100.0 1000
DAPK3 DAPK3 99.0 1000
DCLK1 DCAMKL1 92.0 1000
DCLK2 DCAMKL2 100.0 1000
DCLK3 DCAMKL3 92.0 1000
DDR1 DDR1 75.0 1000
DDR2 DDR2 71.0 1000
MAP3K12 DLK 64.0 1000
DMPK DMPK 91.0 1000
CDC42BPG DMPK2 100.0 1000
STK17A DRAK1 34.0 1000
STK17B DRAK2 52.0 1000
DYRK1A DYRK1A 77.0 1000
DYRK1B DYRK1B 100.0 1000
DYRK2 DYRK2 81.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 54.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 63.0 1000
EPHA4 EPHA4 92.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 100.0 1000
EPHA8 EPHA8 100.0 1000
EPHB1 EPHB1 97.0 1000
EPHB2 EPHB2 100.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 69.0 1000
ERBB2 ERBB2 87.0 1000
ERBB3 ERBB3 63.0 1000
ERBB4 ERBB4 99.0 1000
MAPK3 ERK1 100.0 1000
MAPK1 ERK2 100.0 1000
MAPK6 ERK3 100.0 1000
MAPK4 ERK4 100.0 1000
MAPK7 ERK5 91.0 1000
MAPK15 ERK8 73.0 1000
ERN1 ERN1 62.0 1000
PTK2 FAK 100.0 1000
FER FER 100.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 100.0 1000
FGFR2 FGFR2 100.0 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 92.0 1000
FGR FGR 98.0 1000
FLT1 FLT1 100.0 1000
FLT3 FLT3-autoinhibited 71.0 1000
FLT4 FLT4 63.0 1000
FRK FRK 85.0 1000
FYN FYN 68.0 1000
GAK GAK 82.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 1000
GRK1 GRK1 90.0 1000
GRK2 GRK2 57.0 1000
GRK3 GRK3 78.0 1000
GRK4 GRK4 100.0 1000
GRK7 GRK7 90.0 1000
GSK3A GSK3A 75.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 80.0 1000
HIPK1 HIPK1 74.0 1000
HIPK2 HIPK2 86.0 1000
HIPK3 HIPK3 100.0 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 91.0 1000
HUNK HUNK 80.0 1000
CILK1 ICK 100.0 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 69.0 1000
IKBKB IKK-beta 80.0 1000
IKBKE IKK-epsilon 13.0 1000
INSR INSR 100.0 1000
INSRR INSRR 95.0 1000
IRAK1 IRAK1 44.0 1000
IRAK3 IRAK3 97.0 1000
IRAK4 IRAK4 39.0 1000
ITK ITK 100.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 68.0 1000
JAK2 JAK2(JH1domain-catalytic) 44.0 1000
JAK3 JAK3(JH1domain-catalytic) 71.0 1000
MAPK8 JNK1 63.0 1000
MAPK9 JNK2 47.0 1000
MAPK10 JNK3 51.0 1000
KIT KIT-autoinhibited 96.0 1000
LATS1 LATS1 95.0 1000
LATS2 LATS2 53.0 1000
LCK LCK 100.0 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 100.0 1000
STK11 LKB1 99.0 1000
STK10 LOK 54.0 1000
LRRK2 LRRK2(G2019S) 69.0 1000
LTK LTK 88.0 1000
LYN LYN 94.0 1000
MAP3K13 LZK 86.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 100.0 1000
MAP3K15 MAP3K15 75.0 1000
MAP3K2 MAP3K2 78.0 1000
MAP3K3 MAP3K3 50.0 1000
MAP3K4 MAP3K4 100.0 1000
MAP4K2 MAP4K2 69.0 1000
MAP4K3 MAP4K3 74.0 1000
MAP4K4 MAP4K4 100.0 1000
MAP4K5 MAP4K5 100.0 1000
MAPKAPK2 MAPKAPK2 100.0 1000
MAPKAPK5 MAPKAPK5 96.0 1000
MARK1 MARK1 100.0 1000
MARK2 MARK2 68.0 1000
MARK3 MARK3 100.0 1000
MARK4 MARK4 100.0 1000
MAST1 MAST1 86.0 1000
MAP2K1 MEK1 78.0 1000
MAP2K2 MEK2 74.0 1000
MAP2K3 MEK3 73.0 1000
MAP2K4 MEK4 92.0 1000
MAP2K5 MEK5 1.8 1000
MAP2K6 MEK6 92.0 1000
MELK MELK 95.0 1000
MERTK MERTK 87.0 1000
MET MET(Y1235D) 68.0 1000
MINK1 MINK 57.0 1000
MAP2K7 MKK7 100.0 1000
MKNK1 MKNK1 62.0 1000
MKNK2 MKNK2 37.0 1000
MYLK3 MLCK 90.0 1000
MAP3K9 MLK1 90.0 1000
MAP3K10 MLK2 100.0 1000
MAP3K11 MLK3 100.0 1000
CDC42BPA MRCKA 100.0 1000
CDC42BPB MRCKB 96.0 1000
STK4 MST1 95.0 1000
MST1R MST1R 98.0 1000
STK3 MST2 100.0 1000
STK24 MST3 90.0 1000
STK26 MST4 91.0 1000
MTOR MTOR 100.0 1000
MUSK MUSK 100.0 1000
MYLK MYLK 68.0 1000
MYLK2 MYLK2 100.0 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 100.0 1000
STK38 NDR1 80.0 1000
STK38L NDR2 74.0 1000
NEK1 NEK1 88.0 1000
NEK10 NEK10 72.0 1000
NEK11 NEK11 55.0 1000
NEK2 NEK2 86.0 1000
NEK3 NEK3 69.0 1000
NEK4 NEK4 84.0 1000
NEK5 NEK5 100.0 1000
NEK6 NEK6 98.0 1000
NEK7 NEK7 100.0 1000
NEK9 NEK9 100.0 1000
MAP3K14 NIK 62.0 1000
NIM1K NIM1 61.0 1000
NLK NLK 88.0 1000
OXSR1 OSR1 94.0 1000
MAPK14 p38-alpha 100.0 1000
MAPK11 p38-beta 97.0 1000
MAPK13 p38-delta 100.0 1000
MAPK12 p38-gamma 68.0 1000
PAK1 PAK1 100.0 1000
PAK2 PAK2 100.0 1000
PAK3 PAK3 81.0 1000
PAK4 PAK4 100.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 85.0 1000
CDK16 PCTK1 74.0 1000
CDK17 PCTK2 100.0 1000
CDK18 PCTK3 100.0 1000
PDGFRA PDGFRA 61.0 1000
PDGFRB PDGFRB 100.0 1000
PDPK1 PDPK1 100.0 1000
CDPK1 PFCDPK1(P.falciparum) 100.0 1000
PK5 PFPK5(P.falciparum) 85.0 1000
CDK15 PFTAIRE2 100.0 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 96.0 1000
PHKG2 PHKG2 100.0 1000
PIK3C2B PIK3C2B 100.0 1000
PIK3C2G PIK3C2G 83.0 1000
PIK3CA PIK3CA(Q546K) 30.0 1000
PIK3CB PIK3CB 82.0 1000
PIK3CD PIK3CD 67.0 1000
PIK3CG PIK3CG 100.0 1000
PI4KB PIK4CB 100.0 1000
PIKFYVE PIKFYVE 81.0 1000
PIM1 PIM1 100.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 96.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 52.0 1000
PIP4K2C PIP5K2C 95.0 1000
PRKACA PKAC-alpha 100.0 1000
PRKACB PKAC-beta 76.0 1000
PKMYT1 PKMYT1 75.0 1000
PKN1 PKN1 100.0 1000
PKN2 PKN2 85.0 1000
PKNB PKNB(M.tuberculosis) 100.0 1000
PLK1 PLK1 59.0 1000
PLK2 PLK2 100.0 1000
PLK3 PLK3 100.0 1000
PLK4 PLK4 76.0 1000
PRKCD PRKCD 100.0 1000
PRKCE PRKCE 100.0 1000
PRKCH PRKCH 100.0 1000
PRKCI PRKCI 79.0 1000
PRKCQ PRKCQ 100.0 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 84.0 1000
PRKD3 PRKD3 88.0 1000
PRKG1 PRKG1 94.0 1000
PRKG2 PRKG2 40.0 1000
EIF2AK2 PRKR 100.0 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 100.0 1000
PTK2B PYK2 85.0 1000
SIK3 QSK 83.0 1000
RAF1 RAF1 100.0 1000
RET RET(V804M) 93.0 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 81.0 1000
RIOK3 RIOK3 92.0 1000
RIPK1 RIPK1 93.0 1000
RIPK2 RIPK2 37.0 1000
RIPK4 RIPK4 100.0 1000
DSTYK RIPK5 95.0 1000
ROCK1 ROCK1 100.0 1000
ROCK2 ROCK2 91.0 1000
ROS1 ROS1 100.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 73.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 85.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 98.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 87.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 81.0 1000
RPS6KB1 S6K1 92.0 1000
SBK1 SBK1 71.0 1000
SGK1 SGK 37.0 1000
SBK3 SgK110 100.0 1000
SGK2 SGK2 43.0 1000
SGK3 SGK3 72.0 1000
SIK1 SIK 94.0 1000
SIK2 SIK2 59.0 1000
SLK SLK 100.0 1000
NUAK2 SNARK 66.0 1000
SNRK SNRK 100.0 1000
SRC SRC 100.0 1000
SRMS SRMS 88.0 1000
SRPK1 SRPK1 47.0 1000
SRPK2 SRPK2 76.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 100.0 1000
STK35 STK35 83.0 1000
STK36 STK36 98.0 1000
STK39 STK39 69.0 1000
SYK SYK 96.0 1000
MAP3K7 TAK1 74.0 1000
TAOK1 TAOK1 77.0 1000
TAOK2 TAOK2 80.0 1000
TAOK3 TAOK3 33.0 1000
TBK1 TBK1 24.0 1000
TEC TEC 100.0 1000
TESK1 TESK1 78.0 1000
TGFBR1 TGFBR1 100.0 1000
TGFBR2 TGFBR2 85.0 1000
TIE1 TIE1 66.0 1000
TEK TIE2 87.0 1000
TLK1 TLK1 89.0 1000
TLK2 TLK2 100.0 1000
TNIK TNIK 53.0 1000
TNK1 TNK1 96.0 1000
TNK2 TNK2 96.0 1000
TNNI3K TNNI3K 50.0 1000
NTRK1 TRKA 38.0 1000
NTRK2 TRKB 63.0 1000
NTRK3 TRKC 61.0 1000
TRPM6 TRPM6 100.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 62.0 1000
TTK TTK 100.0 1000
TXK TXK 95.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 77.0 1000
TYRO3 TYRO3 100.0 1000
ULK1 ULK1 75.0 1000
ULK2 ULK2 64.0 1000
ULK3 ULK3 61.0 1000
KDR VEGFR2 74.0 1000
PIK3C3 VPS34 100.0 1000
VRK2 VRK2 88.0 1000
WEE1 WEE1 100.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 86.0 1000
WNK2 WNK2 59.0 1000
WNK3 WNK3 85.0 1000
WNK4 WNK4 53.0 1000
STK32A YANK1 85.0 1000
STK32B YANK2 100.0 1000
STK32C YANK3 100.0 1000
YES1 YES 76.0 1000
STK25 YSK1 100.0 1000
MAP3K19 YSK4 15.0 1000
MAP3K20 ZAK 65.0 1000
ZAP70 ZAP70 100.0 1000

Jump to DiscoverX top