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Selectivity data for probe BI 665915 and control BI-0153


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BI 665915


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A 6.78
5-HT1B HTR1B -3.77
5-HT1D HTR1D -5.95
5-HT1E HTR1E -14.02
5-HT2A HTR2A -11.89
5-HT2B HTR2B -5.40
5-HT2C HTR2C 0.50
5-HT3 HTR3A -2.76
5-HT5A HTR5A -4.97
5-HT6 HTR6 -10.08
5-HT7A HTR7 -27.71
D1 DRD1 4.55
D2 DRD2 13.58
D3 DRD3 -5.98
D4 DRD4 1.48
D5 DRD5 9.24
SERT SLC6A4 6.28
NET SLC6A2 18.94
DAT SLC6A3 60.66
MOR OPRM1 4.55
DOR OPRD1 -7.13
KOR OPRK1 33.86
GABAA -11.09
H1 HRH1 7.66
H2 HRH2 -8.40
H3 HRH3 10.97
H4 HRH4 55.22
Alpha1A ADRA1A 4.68
Alpha1B ADRA1B 2.84
Alpha2A ADRA2A -3.33
Alpha2B ADRA2B -19.24
Alpha2C ADRA2C -10.46
Beta1 ADRB1 -12.83
Beta2 ADRB2 0.50
M1 CHRM1 -4.93
M2 CHRM2 -7.52
M3 CHRM3 7.43
M4 CHRM4 10.33
M5 CHRM5 5.21
Beta3 ADRB3 9.54
GABAA/BZP 25.51
GABA/PBR 1.51
Alpha1D ADRA1D -3.06
Sigma 2 TMEM97 10.05
Sigma 1 SIGMAR1 -25.20

BI-0153


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A 31.48
5-HT1B HTR1B -13.92
5-HT1D HTR1D -3.06
5-HT1E HTR1E -7.33
5-HT2A HTR2A -18.13
5-HT2B HTR2B -11.59
5-HT2C HTR2C 9.74
5-HT3 HTR3A -8.52
5-HT5A HTR5A 0.23
5-HT6 HTR6 -7.48
5-HT7A HTR7 -27.29
D1 DRD1 -6.69
D2 DRD2 16.09
D3 DRD3 -2.44
D4 DRD4 1.18
D5 DRD5 22.80
SERT SLC6A4 5.35
NET SLC6A2 8.33
DAT SLC6A3 52.36 855.00 6.10
MOR OPRM1 12.62
DOR OPRD1 -5.53
KOR OPRK1 16.22
GABAA 6.54
H1 HRH1 8.78
H2 HRH2 -9.18
H3 HRH3 3.45
H4 HRH4 36.60
Alpha1A ADRA1A 13.89
Alpha1B ADRA1B 5.11
Alpha2A ADRA2A 22.38
Alpha2B ADRA2B -3.57
Alpha2C ADRA2C 4.10
Beta1 ADRB1 7.58
Beta2 ADRB2 3.55
M1 CHRM1 -14.40
M2 CHRM2 -0.31
M3 CHRM3 -11.20
M4 CHRM4 5.81
M5 CHRM5 -1.63
Beta3 ADRB3 3.05
GABAA/BZP 19.36
GABA/PBR 7.97
Alpha1D ADRA1D -15.43
Sigma 2 TMEM97 25.01
Sigma 1 SIGMAR1 -4.19

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
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BI 665915


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 92.0 1000
ABL2 ABL2 100.0 1000
ACVR1 ACVR1 84.0 1000
ACVR1B ACVR1B 89.0 1000
ACVR2A ACVR2A 81.0 1000
ACVR2B ACVR2B 81.0 1000
ACVRL1 ACVRL1 84.0 1000
COQ8A ADCK3 100.0 1000
COQ8B ADCK4 92.0 1000
AKT1 AKT1 94.0 1000
AKT2 AKT2 84.0 1000
AKT3 AKT3 100.0 1000
ALK ALK(L1196M) 90.0 1000
PRKAA1 AMPK-alpha1 95.0 1000
PRKAA2 AMPK-alpha2 100.0 1000
ANKK1 ANKK1 81.0 1000
NUAK1 ARK5 100.0 1000
MAP3K5 ASK1 99.0 1000
MAP3K6 ASK2 90.0 1000
AURKA AURKA 73.0 1000
AURKB AURKB 96.0 1000
AURKC AURKC 100.0 1000
AXL AXL 98.0 1000
BMP2K BIKE 100.0 1000
BLK BLK 98.0 1000
BMPR1A BMPR1A 100.0 1000
BMPR1B BMPR1B 76.0 1000
BMPR2 BMPR2 94.0 1000
BMX BMX 93.0 1000
BRAF BRAF(V600E) 89.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 98.0 1000
BRSK2 BRSK2 100.0 1000
BTK BTK 73.0 1000
BUB1 BUB1 75.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 88.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 96.0 1000
CAMK2B CAMK2B 96.0 1000
CAMK2D CAMK2D 100.0 1000
CAMK2G CAMK2G 100.0 1000
CAMK4 CAMK4 83.0 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 100.0 1000
CASK CASK 82.0 1000
CDK11B CDC2L1 79.0 1000
CDK11A CDC2L2 100.0 1000
CDK13 CDC2L5 83.0 1000
CDK19 CDK11 100.0 1000
CDK2 CDK2 96.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 94.0 1000
CDK5 CDK5 100.0 1000
CDK7 CDK7 59.0 1000
CDK8 CDK8 89.0 1000
CDK9 CDK9 96.0 1000
CDKL1 CDKL1 92.0 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 94.0 1000
CDKL5 CDKL5 89.0 1000
CHEK1 CHEK1 85.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 84.0 1000
CLK1 CLK1 93.0 1000
CLK2 CLK2 96.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 99.0 1000
CSF1R CSF1R-autoinhibited 96.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 100.0 1000
CSNK1A1L CSNK1A1L 100.0 1000
CSNK1D CSNK1D 96.0 1000
CSNK1E CSNK1E 97.0 1000
CSNK1G1 CSNK1G1 100.0 1000
CSNK1G2 CSNK1G2 100.0 1000
CSNK1G3 CSNK1G3 95.0 1000
CSNK2A1 CSNK2A1 88.0 1000
CSNK2A2 CSNK2A2 90.0 1000
MATK CTK 77.0 1000
DAPK1 DAPK1 82.0 1000
DAPK2 DAPK2 100.0 1000
DAPK3 DAPK3 92.0 1000
DCLK1 DCAMKL1 71.0 1000
DCLK2 DCAMKL2 91.0 1000
DCLK3 DCAMKL3 96.0 1000
DDR1 DDR1 90.0 1000
DDR2 DDR2 89.0 1000
MAP3K12 DLK 80.0 1000
DMPK DMPK 100.0 1000
CDC42BPG DMPK2 87.0 1000
STK17A DRAK1 100.0 1000
STK17B DRAK2 88.0 1000
DYRK1A DYRK1A 73.0 1000
DYRK1B DYRK1B 98.0 1000
DYRK2 DYRK2 89.0 1000
EGFR EGFR(T790M) 100.0 1000
EIF2AK1 EIF2AK1 96.0 1000
EPHA1 EPHA1 97.0 1000
EPHA2 EPHA2 100.0 1000
EPHA3 EPHA3 100.0 1000
EPHA4 EPHA4 100.0 1000
EPHA5 EPHA5 100.0 1000
EPHA6 EPHA6 100.0 1000
EPHA7 EPHA7 98.0 1000
EPHA8 EPHA8 100.0 1000
EPHB1 EPHB1 100.0 1000
EPHB2 EPHB2 87.0 1000
EPHB3 EPHB3 100.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 76.0 1000
ERBB2 ERBB2 100.0 1000
ERBB3 ERBB3 95.0 1000
ERBB4 ERBB4 100.0 1000
MAPK3 ERK1 100.0 1000
MAPK1 ERK2 100.0 1000
MAPK6 ERK3 91.0 1000
MAPK4 ERK4 88.0 1000
MAPK7 ERK5 90.0 1000
MAPK15 ERK8 91.0 1000
ERN1 ERN1 86.0 1000
PTK2 FAK 100.0 1000
FER FER 94.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 95.0 1000
FGFR2 FGFR2 85.0 1000
FGFR3 FGFR3(G697C) 89.0 1000
FGFR4 FGFR4 88.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 100.0 1000
FLT3 FLT3-autoinhibited 82.0 1000
FLT4 FLT4 88.0 1000
FRK FRK 90.0 1000
FYN FYN 86.0 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 1000
GRK1 GRK1 100.0 1000
GRK2 GRK2 78.0 1000
GRK3 GRK3 86.0 1000
GRK4 GRK4 86.0 1000
GRK7 GRK7 0.0 1000
GSK3A GSK3A 100.0 1000
GSK3B GSK3B 100.0 1000
HASPIN HASPIN 100.0 1000
HCK HCK 79.0 1000
HIPK1 HIPK1 96.0 1000
HIPK2 HIPK2 87.0 1000
HIPK3 HIPK3 97.0 1000
HIPK4 HIPK4 70.0 1000
MAP4K1 HPK1 100.0 1000
HUNK HUNK 100.0 1000
CILK1 ICK 100.0 1000
IGF1R IGF1R 100.0 1000
CHUK IKK-alpha 0.0 1000
IKBKB IKK-beta 100.0 1000
IKBKE IKK-epsilon 86.0 1000
INSR INSR 89.0 1000
INSRR INSRR 99.0 1000
IRAK1 IRAK1 85.0 1000
IRAK3 IRAK3 100.0 1000
IRAK4 IRAK4 85.0 1000
ITK ITK 99.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 33.0 1000
JAK2 JAK2(JH1domain-catalytic) 73.0 1000
JAK3 JAK3(JH1domain-catalytic) 95.0 1000
MAPK8 JNK1 51.0 1000
MAPK9 JNK2 75.0 1000
MAPK10 JNK3 94.0 1000
KIT KIT-autoinhibited 86.0 1000
LATS1 LATS1 93.0 1000
LATS2 LATS2 74.0 1000
LCK LCK 86.0 1000
LIMK1 LIMK1 81.0 1000
LIMK2 LIMK2 85.0 1000
STK11 LKB1 77.0 1000
STK10 LOK 89.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 89.0 1000
LYN LYN 87.0 1000
MAP3K13 LZK 92.0 1000
MAK MAK 100.0 1000
MAP3K1 MAP3K1 90.0 1000
MAP3K15 MAP3K15 99.0 1000
MAP3K2 MAP3K2 94.0 1000
MAP3K3 MAP3K3 86.0 1000
MAP3K4 MAP3K4 91.0 1000
MAP4K2 MAP4K2 100.0 1000
MAP4K3 MAP4K3 100.0 1000
MAP4K4 MAP4K4 90.0 1000
MAP4K5 MAP4K5 86.0 1000
MAPKAPK2 MAPKAPK2 92.0 1000
MAPKAPK5 MAPKAPK5 94.0 1000
MARK1 MARK1 92.0 1000
MARK2 MARK2 100.0 1000
MARK3 MARK3 99.0 1000
MARK4 MARK4 95.0 1000
MAST1 MAST1 97.0 1000
MAP2K1 MEK1 89.0 1000
MAP2K2 MEK2 86.0 1000
MAP2K3 MEK3 83.0 1000
MAP2K4 MEK4 100.0 1000
MAP2K5 MEK5 62.0 1000
MAP2K6 MEK6 100.0 1000
MELK MELK 87.0 1000
MERTK MERTK 100.0 1000
MET MET(Y1235D) 96.0 1000
MINK1 MINK 85.0 1000
MAP2K7 MKK7 94.0 1000
MKNK1 MKNK1 85.0 1000
MKNK2 MKNK2 88.0 1000
MYLK3 MLCK 100.0 1000
MAP3K9 MLK1 100.0 1000
MAP3K10 MLK2 83.0 1000
MAP3K11 MLK3 77.0 1000
CDC42BPA MRCKA 100.0 1000
CDC42BPB MRCKB 99.0 1000
STK4 MST1 90.0 1000
MST1R MST1R 79.0 1000
STK3 MST2 100.0 1000
STK24 MST3 100.0 1000
STK26 MST4 97.0 1000
MTOR MTOR 100.0 1000
MUSK MUSK 100.0 1000
MYLK MYLK 84.0 1000
MYLK2 MYLK2 100.0 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 70.0 1000
STK38 NDR1 80.0 1000
STK38L NDR2 91.0 1000
NEK1 NEK1 100.0 1000
NEK10 NEK10 97.0 1000
NEK11 NEK11 100.0 1000
NEK2 NEK2 97.0 1000
NEK3 NEK3 87.0 1000
NEK4 NEK4 88.0 1000
NEK5 NEK5 89.0 1000
NEK6 NEK6 100.0 1000
NEK7 NEK7 90.0 1000
NEK9 NEK9 95.0 1000
MAP3K14 NIK 92.0 1000
NIM1K NIM1 86.0 1000
NLK NLK 95.0 1000
OXSR1 OSR1 86.0 1000
MAPK14 p38-alpha 90.0 1000
MAPK11 p38-beta 97.0 1000
MAPK13 p38-delta 93.0 1000
MAPK12 p38-gamma 94.0 1000
PAK1 PAK1 100.0 1000
PAK2 PAK2 90.0 1000
PAK3 PAK3 87.0 1000
PAK4 PAK4 96.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 100.0 1000
CDK16 PCTK1 86.0 1000
CDK17 PCTK2 96.0 1000
CDK18 PCTK3 100.0 1000
PDGFRA PDGFRA 100.0 1000
PDGFRB PDGFRB 82.0 1000
PDPK1 PDPK1 99.0 1000
CDPK1 PFCDPK1(P.falciparum) 58.0 1000
PK5 PFPK5(P.falciparum) 0.0 1000
CDK15 PFTAIRE2 94.0 1000
CDK14 PFTK1 99.0 1000
PHKG1 PHKG1 77.0 1000
PHKG2 PHKG2 80.0 1000
PIK3C2B PIK3C2B 96.0 1000
PIK3C2G PIK3C2G 66.0 1000
PIK3CA PIK3CA(Q546K) 95.0 1000
PIK3CB PIK3CB 100.0 1000
PIK3CD PIK3CD 93.0 1000
PIK3CG PIK3CG 72.0 1000
PI4KB PIK4CB 92.0 1000
PIKFYVE PIKFYVE 68.0 1000
PIM1 PIM1 100.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 96.0 1000
PIP5K1A PIP5K1A 90.0 1000
PIP5K1C PIP5K1C 100.0 1000
PIP4K2B PIP5K2B 100.0 1000
PIP4K2C PIP5K2C 100.0 1000
PRKACA PKAC-alpha 87.0 1000
PRKACB PKAC-beta 100.0 1000
PKMYT1 PKMYT1 88.0 1000
PKN1 PKN1 99.0 1000
PKN2 PKN2 100.0 1000
PKNB PKNB(M.tuberculosis) 100.0 1000
PLK1 PLK1 77.0 1000
PLK2 PLK2 56.0 1000
PLK3 PLK3 89.0 1000
PLK4 PLK4 74.0 1000
PRKCD PRKCD 98.0 1000
PRKCE PRKCE 44.0 1000
PRKCH PRKCH 100.0 1000
PRKCI PRKCI 93.0 1000
PRKCQ PRKCQ 92.0 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 100.0 1000
PRKD3 PRKD3 100.0 1000
PRKG1 PRKG1 100.0 1000
PRKG2 PRKG2 85.0 1000
EIF2AK2 PRKR 100.0 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 86.0 1000
PTK2B PYK2 87.0 1000
SIK3 QSK 70.0 1000
RAF1 RAF1 100.0 1000
RET RET(V804M) 97.0 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 87.0 1000
RIOK3 RIOK3 100.0 1000
RIPK1 RIPK1 82.0 1000
RIPK2 RIPK2 87.0 1000
RIPK4 RIPK4 93.0 1000
DSTYK RIPK5 57.0 1000
ROCK1 ROCK1 97.0 1000
ROCK2 ROCK2 100.0 1000
ROS1 ROS1 88.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 72.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 92.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 99.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KB1 S6K1 83.0 1000
SBK1 SBK1 87.0 1000
SGK1 SGK 91.0 1000
SBK3 SgK110 71.0 1000
SGK2 SGK2 83.0 1000
SGK3 SGK3 76.0 1000
SIK1 SIK 52.0 1000
SIK2 SIK2 93.0 1000
SLK SLK 94.0 1000
NUAK2 SNARK 83.0 1000
SNRK SNRK 89.0 1000
SRC SRC 90.0 1000
SRMS SRMS 93.0 1000
SRPK1 SRPK1 100.0 1000
SRPK2 SRPK2 100.0 1000
SRPK3 SRPK3 85.0 1000
STK16 STK16 100.0 1000
STK33 STK33 100.0 1000
STK35 STK35 88.0 1000
STK36 STK36 79.0 1000
STK39 STK39 81.0 1000
SYK SYK 73.0 1000
MAP3K7 TAK1 50.0 1000
TAOK1 TAOK1 75.0 1000
TAOK2 TAOK2 81.0 1000
TAOK3 TAOK3 89.0 1000
TBK1 TBK1 85.0 1000
TEC TEC 93.0 1000
TESK1 TESK1 90.0 1000
TGFBR1 TGFBR1 100.0 1000
TGFBR2 TGFBR2 88.0 1000
TIE1 TIE1 90.0 1000
TEK TIE2 100.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 100.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 100.0 1000
TNK2 TNK2 91.0 1000
TNNI3K TNNI3K 92.0 1000
NTRK1 TRKA 70.0 1000
NTRK2 TRKB 81.0 1000
NTRK3 TRKC 92.0 1000
TRPM6 TRPM6 78.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 68.0 1000
TTK TTK 100.0 1000
TXK TXK 96.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 65.0 1000
TYRO3 TYRO3 100.0 1000
ULK1 ULK1 77.0 1000
ULK2 ULK2 100.0 1000
ULK3 ULK3 86.0 1000
KDR VEGFR2 87.0 1000
PIK3C3 VPS34 89.0 1000
VRK2 VRK2 92.0 1000
WEE1 WEE1 94.0 1000
WEE2 WEE2 100.0 1000
WNK1 WNK1 94.0 1000
WNK2 WNK2 100.0 1000
WNK3 WNK3 76.0 1000
WNK4 WNK4 93.0 1000
STK32A YANK1 83.0 1000
STK32B YANK2 100.0 1000
STK32C YANK3 88.0 1000
YES1 YES 94.0 1000
STK25 YSK1 100.0 1000
MAP3K19 YSK4 61.0 1000
MAP3K20 ZAK 80.0 1000
ZAP70 ZAP70 100.0 1000

BI-0153


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 1000
ABL1 ABL1-phosphorylated 100.0 1000
ABL2 ABL2 84.0 1000
ACVR1 ACVR1 95.0 1000
ACVR1B ACVR1B 84.0 1000
ACVR2A ACVR2A 84.0 1000
ACVR2B ACVR2B 96.0 1000
ACVRL1 ACVRL1 86.0 1000
COQ8A ADCK3 99.0 1000
COQ8B ADCK4 100.0 1000
AKT1 AKT1 97.0 1000
AKT2 AKT2 100.0 1000
AKT3 AKT3 87.0 1000
ALK ALK(L1196M) 92.0 1000
PRKAA1 AMPK-alpha1 98.0 1000
PRKAA2 AMPK-alpha2 86.0 1000
ANKK1 ANKK1 81.0 1000
NUAK1 ARK5 82.0 1000
MAP3K5 ASK1 91.0 1000
MAP3K6 ASK2 78.0 1000
AURKA AURKA 82.0 1000
AURKB AURKB 41.0 1000
AURKC AURKC 100.0 1000
AXL AXL 93.0 1000
BMP2K BIKE 99.0 1000
BLK BLK 83.0 1000
BMPR1A BMPR1A 87.0 1000
BMPR1B BMPR1B 99.0 1000
BMPR2 BMPR2 93.0 1000
BMX BMX 88.0 1000
BRAF BRAF(V600E) 87.0 1000
PTK6 BRK 100.0 1000
BRSK1 BRSK1 93.0 1000
BRSK2 BRSK2 77.0 1000
BTK BTK 82.0 1000
BUB1 BUB1 75.0 1000
CAMK1 CAMK1 100.0 1000
PNCK CAMK1B 77.0 1000
CAMK1D CAMK1D 100.0 1000
CAMK1G CAMK1G 100.0 1000
CAMK2A CAMK2A 100.0 1000
CAMK2B CAMK2B 94.0 1000
CAMK2D CAMK2D 99.0 1000
CAMK2G CAMK2G 98.0 1000
CAMK4 CAMK4 100.0 1000
CAMKK1 CAMKK1 100.0 1000
CAMKK2 CAMKK2 100.0 1000
CASK CASK 76.0 1000
CDK11B CDC2L1 96.0 1000
CDK11A CDC2L2 89.0 1000
CDK13 CDC2L5 91.0 1000
CDK19 CDK11 93.0 1000
CDK2 CDK2 100.0 1000
CDK3 CDK3 100.0 1000
CDK4 CDK4-cyclinD3 100.0 1000
CDK5 CDK5 100.0 1000
CDK7 CDK7 72.0 1000
CDK8 CDK8 100.0 1000
CDK9 CDK9 100.0 1000
CDKL1 CDKL1 100.0 1000
CDKL2 CDKL2 100.0 1000
CDKL3 CDKL3 80.0 1000
CDKL5 CDKL5 82.0 1000
CHEK1 CHEK1 100.0 1000
CHEK2 CHEK2 100.0 1000
CIT CIT 86.0 1000
CLK1 CLK1 100.0 1000
CLK2 CLK2 94.0 1000
CLK3 CLK3 100.0 1000
CLK4 CLK4 89.0 1000
CSF1R CSF1R-autoinhibited 84.0 1000
CSK CSK 100.0 1000
CSNK1A1 CSNK1A1 62.0 1000
CSNK1A1L CSNK1A1L 98.0 1000
CSNK1D CSNK1D 100.0 1000
CSNK1E CSNK1E 100.0 1000
CSNK1G1 CSNK1G1 90.0 1000
CSNK1G2 CSNK1G2 82.0 1000
CSNK1G3 CSNK1G3 100.0 1000
CSNK2A1 CSNK2A1 73.0 1000
CSNK2A2 CSNK2A2 100.0 1000
MATK CTK 77.0 1000
DAPK1 DAPK1 100.0 1000
DAPK2 DAPK2 86.0 1000
DAPK3 DAPK3 92.0 1000
DCLK1 DCAMKL1 88.0 1000
DCLK2 DCAMKL2 96.0 1000
DCLK3 DCAMKL3 100.0 1000
DDR1 DDR1 86.0 1000
DDR2 DDR2 100.0 1000
MAP3K12 DLK 100.0 1000
DMPK DMPK 82.0 1000
CDC42BPG DMPK2 82.0 1000
STK17A DRAK1 100.0 1000
STK17B DRAK2 100.0 1000
DYRK1A DYRK1A 66.0 1000
DYRK1B DYRK1B 66.0 1000
DYRK2 DYRK2 81.0 1000
EGFR EGFR(T790M) 80.0 1000
EIF2AK1 EIF2AK1 88.0 1000
EPHA1 EPHA1 100.0 1000
EPHA2 EPHA2 89.0 1000
EPHA3 EPHA3 89.0 1000
EPHA4 EPHA4 100.0 1000
EPHA5 EPHA5 41.0 1000
EPHA6 EPHA6 99.0 1000
EPHA7 EPHA7 92.0 1000
EPHA8 EPHA8 87.0 1000
EPHB1 EPHB1 100.0 1000
EPHB2 EPHB2 70.0 1000
EPHB3 EPHB3 95.0 1000
EPHB4 EPHB4 100.0 1000
EPHB6 EPHB6 93.0 1000
ERBB2 ERBB2 80.0 1000
ERBB3 ERBB3 87.0 1000
ERBB4 ERBB4 100.0 1000
MAPK3 ERK1 79.0 1000
MAPK1 ERK2 81.0 1000
MAPK6 ERK3 91.0 1000
MAPK4 ERK4 100.0 1000
MAPK7 ERK5 97.0 1000
MAPK15 ERK8 96.0 1000
ERN1 ERN1 69.0 1000
PTK2 FAK 100.0 1000
FER FER 79.0 1000
FES FES 100.0 1000
FGFR1 FGFR1 72.0 1000
FGFR2 FGFR2 100.0 1000
FGFR3 FGFR3(G697C) 100.0 1000
FGFR4 FGFR4 100.0 1000
FGR FGR 100.0 1000
FLT1 FLT1 100.0 1000
FLT3 FLT3-autoinhibited 81.0 1000
FLT4 FLT4 95.0 1000
FRK FRK 100.0 1000
FYN FYN 100.0 1000
GAK GAK 100.0 1000
EIF2AK4 GCN2(Kin.Dom.2,S808G) 83.0 1000
GRK1 GRK1 74.0 1000
GRK2 GRK2 67.0 1000
GRK3 GRK3 69.0 1000
GRK4 GRK4 100.0 1000
GRK7 GRK7 84.0 1000
GSK3A GSK3A 100.0 1000
GSK3B GSK3B 81.0 1000
HASPIN HASPIN 74.0 1000
HCK HCK 100.0 1000
HIPK1 HIPK1 63.0 1000
HIPK2 HIPK2 94.0 1000
HIPK3 HIPK3 71.0 1000
HIPK4 HIPK4 100.0 1000
MAP4K1 HPK1 81.0 1000
HUNK HUNK 96.0 1000
CILK1 ICK 76.0 1000
IGF1R IGF1R 85.0 1000
CHUK IKK-alpha 100.0 1000
IKBKB IKK-beta 90.0 1000
IKBKE IKK-epsilon 57.0 1000
INSR INSR 90.0 1000
INSRR INSRR 100.0 1000
IRAK1 IRAK1 77.0 1000
IRAK3 IRAK3 96.0 1000
IRAK4 IRAK4 84.0 1000
ITK ITK 92.0 1000
JAK1 JAK1(JH2domain-pseudokinase) 100.0 1000
JAK2 JAK2(JH1domain-catalytic) 65.0 1000
JAK3 JAK3(JH1domain-catalytic) 80.0 1000
MAPK8 JNK1 78.0 1000
MAPK9 JNK2 81.0 1000
MAPK10 JNK3 93.0 1000
KIT KIT-autoinhibited 77.0 1000
RIPK1 RIPK1 89.0 1000
LATS1 LATS1 100.0 1000
LATS2 LATS2 46.0 1000
LCK LCK 83.0 1000
LIMK1 LIMK1 100.0 1000
LIMK2 LIMK2 85.0 1000
STK11 LKB1 100.0 1000
STK10 LOK 100.0 1000
LRRK2 LRRK2(G2019S) 100.0 1000
LTK LTK 90.0 1000
LYN LYN 79.0 1000
MAP3K13 LZK 100.0 1000
MAK MAK 87.0 1000
MAP3K1 MAP3K1 77.0 1000
MAP3K15 MAP3K15 100.0 1000
MAP3K2 MAP3K2 93.0 1000
MAP3K3 MAP3K3 81.0 1000
MAP3K4 MAP3K4 92.0 1000
MAP4K2 MAP4K2 89.0 1000
MAP4K3 MAP4K3 89.0 1000
MAP4K4 MAP4K4 66.0 1000
MAP4K5 MAP4K5 89.0 1000
MAPKAPK2 MAPKAPK2 99.0 1000
MAPKAPK5 MAPKAPK5 92.0 1000
MARK1 MARK1 100.0 1000
MARK2 MARK2 92.0 1000
MARK3 MARK3 100.0 1000
MARK4 MARK4 96.0 1000
MAST1 MAST1 100.0 1000
MAP2K1 MEK1 82.0 1000
MAP2K2 MEK2 80.0 1000
MAP2K3 MEK3 71.0 1000
MAP2K4 MEK4 93.0 1000
MAP2K5 MEK5 72.0 1000
MAP2K6 MEK6 100.0 1000
MELK MELK 92.0 1000
MERTK MERTK 88.0 1000
MET MET(Y1235D) 98.0 1000
MINK1 MINK 91.0 1000
MAP2K7 MKK7 87.0 1000
MKNK1 MKNK1 85.0 1000
MKNK2 MKNK2 94.0 1000
MYLK3 MLCK 100.0 1000
MAP3K9 MLK1 91.0 1000
MAP3K10 MLK2 62.0 1000
MAP3K11 MLK3 87.0 1000
CDC42BPA MRCKA 100.0 1000
CDC42BPB MRCKB 85.0 1000
STK4 MST1 90.0 1000
MST1R MST1R 95.0 1000
STK3 MST2 100.0 1000
STK24 MST3 100.0 1000
STK26 MST4 89.0 1000
MTOR MTOR 91.0 1000
MUSK MUSK 100.0 1000
MYLK MYLK 72.0 1000
MYLK2 MYLK2 90.0 1000
MYLK4 MYLK4 100.0 1000
MYO3A MYO3A 100.0 1000
MYO3B MYO3B 100.0 1000
STK38 NDR1 84.0 1000
STK38L NDR2 81.0 1000
NEK1 NEK1 100.0 1000
NEK10 NEK10 99.0 1000
NEK11 NEK11 90.0 1000
NEK2 NEK2 100.0 1000
NEK3 NEK3 57.0 1000
NEK4 NEK4 95.0 1000
NEK5 NEK5 89.0 1000
NEK6 NEK6 81.0 1000
NEK7 NEK7 100.0 1000
NEK9 NEK9 100.0 1000
MAP3K14 NIK 83.0 1000
NIM1K NIM1 83.0 1000
NLK NLK 94.0 1000
OXSR1 OSR1 82.0 1000
MAPK14 p38-alpha 100.0 1000
MAPK11 p38-beta 86.0 1000
MAPK13 p38-delta 91.0 1000
MAPK12 p38-gamma 62.0 1000
PAK1 PAK1 100.0 1000
PAK2 PAK2 100.0 1000
PAK3 PAK3 82.0 1000
PAK4 PAK4 100.0 1000
PAK6 PAK6 100.0 1000
PAK5 PAK7 88.0 1000
CDK16 PCTK1 80.0 1000
CDK17 PCTK2 100.0 1000
CDK18 PCTK3 83.0 1000
PDGFRA PDGFRA 83.0 1000
PDGFRB PDGFRB 94.0 1000
PDPK1 PDPK1 82.0 1000
CDPK1 PFCDPK1(P.falciparum) 82.0 1000
PK5 PFPK5(P.falciparum) 100.0 1000
CDK15 PFTAIRE2 100.0 1000
CDK14 PFTK1 100.0 1000
PHKG1 PHKG1 97.0 1000
PHKG2 PHKG2 91.0 1000
PIK3C2B PIK3C2B 100.0 1000
PIK3C2G PIK3C2G 76.0 1000
PIK3CA PIK3CA(Q546K) 100.0 1000
PIK3CB PIK3CB 96.0 1000
PIK3CD PIK3CD 100.0 1000
PIK3CG PIK3CG 85.0 1000
PI4KB PIK4CB 70.0 1000
PIKFYVE PIKFYVE 98.0 1000
PIM1 PIM1 100.0 1000
PIM2 PIM2 100.0 1000
PIM3 PIM3 100.0 1000
PIP5K1A PIP5K1A 95.0 1000
PIP5K1C PIP5K1C 96.0 1000
PIP4K2B PIP5K2B 71.0 1000
PIP4K2C PIP5K2C 100.0 1000
PRKACA PKAC-alpha 91.0 1000
PRKACB PKAC-beta 86.0 1000
PKMYT1 PKMYT1 90.0 1000
PKN1 PKN1 84.0 1000
PKN2 PKN2 77.0 1000
PKNB PKNB(M.tuberculosis) 85.0 1000
PLK1 PLK1 82.0 1000
PLK2 PLK2 93.0 1000
PLK3 PLK3 89.0 1000
PLK4 PLK4 100.0 1000
PRKCD PRKCD 67.0 1000
PRKCE PRKCE 90.0 1000
PRKCH PRKCH 91.0 1000
PRKCI PRKCI 100.0 1000
PRKCQ PRKCQ 89.0 1000
PRKD1 PRKD1 100.0 1000
PRKD2 PRKD2 89.0 1000
PRKD3 PRKD3 92.0 1000
PRKG1 PRKG1 89.0 1000
PRKG2 PRKG2 100.0 1000
EIF2AK2 PRKR 100.0 1000
PRKX PRKX 100.0 1000
PRPF4B PRP4 87.0 1000
PTK2B PYK2 90.0 1000
SIK3 QSK 100.0 1000
RAF1 RAF1 100.0 1000
RET RET(V804M) 100.0 1000
RIOK1 RIOK1 100.0 1000
RIOK2 RIOK2 76.0 1000
RIOK3 RIOK3 89.0 1000
RIPK2 RIPK2 100.0 1000
RIPK4 RIPK4 70.0 1000
DSTYK RIPK5 94.0 1000
ROCK1 ROCK1 83.0 1000
ROCK2 ROCK2 89.0 1000
ROS1 ROS1 87.0 1000
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 86.0 1000
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 67.0 1000
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 85.0 1000
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 1000
RPS6KB1 S6K1 91.0 1000
SBK1 SBK1 83.0 1000
SGK1 SGK 96.0 1000
SBK3 SgK110 99.0 1000
SGK2 SGK2 100.0 1000
SGK3 SGK3 75.0 1000
SIK1 SIK 86.0 1000
SIK2 SIK2 100.0 1000
SLK SLK 77.0 1000
NUAK2 SNARK 87.0 1000
SNRK SNRK 100.0 1000
SRC SRC 84.0 1000
SRMS SRMS 73.0 1000
SRPK1 SRPK1 93.0 1000
SRPK2 SRPK2 91.0 1000
SRPK3 SRPK3 100.0 1000
STK16 STK16 100.0 1000
STK33 STK33 99.0 1000
STK35 STK35 94.0 1000
STK36 STK36 75.0 1000
STK39 STK39 100.0 1000
SYK SYK 77.0 1000
MAP3K7 TAK1 72.0 1000
TAOK1 TAOK1 86.0 1000
TAOK2 TAOK2 100.0 1000
TAOK3 TAOK3 67.0 1000
TBK1 TBK1 87.0 1000
TEC TEC 93.0 1000
TESK1 TESK1 94.0 1000
TGFBR1 TGFBR1 97.0 1000
TGFBR2 TGFBR2 100.0 1000
TIE1 TIE1 98.0 1000
TEK TIE2 88.0 1000
TLK1 TLK1 100.0 1000
TLK2 TLK2 100.0 1000
TNIK TNIK 100.0 1000
TNK1 TNK1 96.0 1000
TNK2 TNK2 96.0 1000
TNNI3K TNNI3K 100.0 1000
NTRK1 TRKA 100.0 1000
NTRK2 TRKB 100.0 1000
NTRK3 TRKC 97.0 1000
TRPM6 TRPM6 86.0 1000
TSSK1B TSSK1B 100.0 1000
TSSK3 TSSK3 97.0 1000
TTK TTK 100.0 1000
TXK TXK 98.0 1000
TYK2 TYK2(JH2domain-pseudokinase) 90.0 1000
TYRO3 TYRO3 83.0 1000
ULK1 ULK1 75.0 1000
ULK2 ULK2 78.0 1000
ULK3 ULK3 68.0 1000
KDR VEGFR2 70.0 1000
PIK3C3 VPS34 96.0 1000
VRK2 VRK2 90.0 1000
WEE1 WEE1 87.0 1000
WEE2 WEE2 99.0 1000
WNK1 WNK1 97.0 1000
WNK2 WNK2 67.0 1000
WNK3 WNK3 87.0 1000
WNK4 WNK4 80.0 1000
STK32A YANK1 97.0 1000
STK32B YANK2 100.0 1000
STK32C YANK3 100.0 1000
YES1 YES 87.0 1000
STK25 YSK1 100.0 1000
MAP3K19 YSK4 73.0 1000
MAP3K20 ZAK 92.0 1000
ZAP70 ZAP70 94.0 1000

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BI 665915

Conclusion: Closest hits at 20 µM are FLT-1 with 64 % inhibition and ABL1 with 67 % inhibition.

Target protein HGNC name Species Cmp. conc. % Control Assay ID
ACHE/H ACHE Homo sapiens 20 µM 98.0 Old_Cerep_64
ALPHA1AH_ANTAG ADRA1A Homo sapiens 20 µM 99.0 Cerep_2338
5HT1A/H HTR1A Homo sapiens 20 µM 77.0 Cerep_131
5HT1B/R HTR1B Rattus norvegicus 20 µM 141.0 Cerep_132
5HT1D/H AG HTR1D Homo sapiens 20 µM 102.0 Old_Cerep_48
5HT2AH_AGON HTR2A Homo sapiens 20 µM 102.0 Cerep_471
5HT2B/H AG HTR2B Homo sapiens 20 µM 103.0 Cerep_1333
5HT2CH_AGON HTR2C Homo sapiens 20 µM 90.0 Cerep_1003
5HT3/H HTR3A Homo sapiens 20 µM 100.0 Cerep_411
5HT4EH_ANTAG HTR4 Homo sapiens 20 µM 111.0 Cerep_501
5HT6/H HTR6 Homo sapiens 20 µM 95.0 Cerep_142
5HT7/H HTR7 Homo sapiens 20 µM 104.0 Cerep_144
5HTTRANS/H SLC6A4 Homo sapiens 20 µM 103.0 Old_Cerep_439
A1H_AGON ADORA1 Homo sapiens 20 µM 81.0 Cerep_442
A2A/H ADORA2A Homo sapiens 20 µM 97.0 Cerep_4
A2B/H ADORA2B Homo sapiens 20 µM 83.0 Cerep_5
A3/H ADORA3 Homo sapiens 20 µM 64.0 Cerep_6
ABL_CE ABL1 Homo sapiens 20 µM 33.0 Old_Cerep_57
ACE(HU) ACE Homo sapiens 20 µM 127.0 Cerep_3441
ACE-2(HU) ACE2 Homo sapiens 20 µM 132.0 Cerep_1954
ALPHA1B/HU ADRA1B Homo sapiens 20 µM 120.0 Cerep_1633
ALPHA2A/HU ADRA2A Homo sapiens 20 µM 101.0 Cerep_13
ALPHA2BH_ANTAG ADRA2B Homo sapiens 20 µM 100.0 Cerep_1344
ALPHA2CH_ANTAG ADRA2C Homo sapiens 20 µM 103.0 Cerep_16
AMPA/R Rattus norvegicus 20 µM 105.0 Cerep_64
ANDROGEN/H AR Homo sapiens 20 µM 102.0 Cerep_933
APJH_AGON APLNR Homo sapiens 20 µM 101.0 Cerep_2154
AT1/H AGTR1 Homo sapiens 20 µM 108.0 Cerep_24
AT2/H AGTR2 Homo sapiens 20 µM 98.0 Cerep_26
ATPASE(NA/K) Sus scrofa 20 µM 99.0 Cerep_2009
B2/HUM BDKRB2 Homo sapiens 20 µM 102.0 Cerep_33
BACE-1 BACE1 Homo sapiens 20 µM 102.0 Cerep_701
BB3H_AGON BRS3 Homo sapiens 20 µM 108.0 Cerep_472
BETA1/HUM ADRB1 Homo sapiens 20 µM 100.0 Cerep_18
BETA2/HUM ADRB2 Homo sapiens 20 µM 98.0 Cerep_20
BETA3/HU ADRB3 Homo sapiens 20 µM 86.0 Old_Cerep_3963
BLT1/H LTB4R Homo sapiens 20 µM 100.0 Old_Cerep_49
BZD/CENTR/R Rattus norvegicus 20 µM 117.0 Cerep_28
CA+/DHPSI/R Rattus norvegicus 20 µM 85.0 Old_Cerep_161
CA+/DILSI/R Rattus norvegicus 20 µM 119.0 Cerep_161
CA+/N/R CACNA1B Rattus norvegicus 20 µM 96.0 Cerep_164
CA+/VERSI/R Rattus norvegicus 20 µM 90.0 Cerep_163
CAMK2ALPHA(H) CAMK2A Homo sapiens 20 µM 111.0 Cerep_14-962KP10
CASPASE-3 CASP3 Homo sapiens 20 µM 98.0 Cerep_774
CATOMETHTRAN COMT Sus scrofa 20 µM 99.0 Cerep_457
CB1/CENTR/H CNR1 Homo sapiens 20 µM 88.0 Old_Cerep_67
CB2/PERIPH/H CNR2 Homo sapiens 20 µM 93.0 Cerep_37
CCKA/H CCKAR Homo sapiens 20 µM 113.0 Old_Cerep_39
CCKB/H CCKBR Homo sapiens 20 µM 119.0 Cerep_41
CCR2/H AG CCR2 Homo sapiens 20 µM 109.0 Cerep_362
CDK2(CYCA)_CE CDK2 Homo sapiens 20 µM 118.0 Old_Cerep_58
CHT1/H SLC5A7 Homo sapiens 20 µM 101.0 Cerep_1552
CL-CHANNEL/R Rattus norvegicus 20 µM 88.0 Old_Cerep_16
COX1_HU PTGS1 Homo sapiens 20 µM 62.0 Cerep_4173
COX2_HU PTGS2 Homo sapiens 20 µM 64.0 Cerep_4186
CRF1/H CRHR1 Homo sapiens 20 µM 148.0 Cerep_1467
D1/H DRD1 Homo sapiens 20 µM 98.0 Cerep_44
D2SH_AGON DRD2 Homo sapiens 20 µM 95.0 Cerep_1322
D3/H SLC6A3 Homo sapiens 20 µM 100.0 Old_Cerep_52
DELTA2/H OPRD1 Homo sapiens 20 µM 100.0 Cerep_114
EP2(H) PTGER2 Homo sapiens 20 µM 97.0 Cerep_1955
ERK2(P42MAPK)_CE MAPK1 Homo sapiens 20 µM 114.0 Old_Cerep_53
ER_ALPHA_AGON ESR1 Homo sapiens 20 µM 96.0 Old_Cerep_5484
ETA/H EDNRA Homo sapiens 20 µM 102.0 Cerep_54
ETB/H EDNRB Homo sapiens 20 µM 109.0 Cerep_56
FLT-1(VEGFR1)_CE FLT1 Homo sapiens 20 µM 36.0 Old_Cerep_59
FPH_AGON PTGFR Homo sapiens 20 µM 84.0 Cerep_1979
GABAA1(H) GABRA1
 GABRB2
 GABRG2
 		Homo sapiens 20 µM 105.0 Cerep_4518
GABAB1BH_ANTAG GABRB1 Homo sapiens 20 µM 101.0 Old_Cerep_69
GABATRANS/R Rattus norvegicus 20 µM 96.0 Cerep_60
GCORTICOID/H NR3C1 Homo sapiens 20 µM 96.0 Old_Cerep_469
GLUCAGONH_AGON GCGR Homo sapiens 20 µM 107.0 Cerep_1407
GLYSTRYANTAG Rattus norvegicus 20 µM 118.0 Old_Cerep_70
GUACYCBASAL GUCY1A1 Homo sapiens 20 µM 95.0 Cerep_3004
H1/PYRIL/HS HRH1 Homo sapiens 20 µM 89.0 Cerep_870
H2/APT/HS HRH2 Homo sapiens 20 µM 96.0 Cerep_1208
H3/NAMEH_H HRH3 Homo sapiens 20 µM 108.0 Cerep_1332
H4/H AG HRH4 Homo sapiens 20 µM 109.0 Cerep_1384
HIV-1/H HIV-1 protease Human immunodeficiency virus 1 20 µM 100.0 Cerep_346
INDUC_NOS NOS2 Mus musculus 20 µM 79.0 Cerep_3185
IRK(INSR)_CE INSR Homo sapiens 20 µM 94.0 Cerep_2898
K+/CA+/R Rattus norvegicus 20 µM 88.0 Cerep_167
KAINATE/RA Rattus norvegicus 20 µM 82.0 Cerep_65
KAPPA/R OPRK1 Rattus norvegicus 20 µM 91.0 Cerep_1971
LTD4/H CYSLTR1 Homo sapiens 20 µM 101.0 Cerep_86
LXR_BETAH_AGON Homo sapiens 20 µM 118.0 Cerep_4468
LYNAKINASE(H) LYN Homo sapiens 20 µM 87.0 Old_Cerep_60
M1/H CHRM1 Homo sapiens 20 µM 99.0 Cerep_91
M2/H CHRM2 Homo sapiens 20 µM 98.0 Cerep_93
M3/H CHRM3 Homo sapiens 20 µM 83.0 Cerep_95
M4/H CHRM4 Homo sapiens 20 µM 103.0 Cerep_96
MAO-A_ANTAG MAOA Rattus norvegicus 20 µM 91.0 Cerep_443
MC1_AGON MC1R Mus musculus 20 µM 101.0 Cerep_644
MC3H_AGON MC3R Homo sapiens 20 µM 94.0 Cerep_447
MC4/HU MC4R Homo sapiens 20 µM 109.0 Cerep_420
MCH1H_AGON MCHR1 Homo sapiens 20 µM 116.0 Cerep_1115
ML2(MT3) NQO2 Cricetinae 20 µM 70.0 Cerep_88
MMP-2 (H) MMP2 Homo sapiens 20 µM 96.0 Cerep_5529
MMP-9 (H) MMP9 Homo sapiens 20 µM 83.0 Old_Cerep_41
MMP1 (H) MMP1 Homo sapiens 20 µM 97.0 Cerep_510
MOTILINH_AGON MLNR Homo sapiens 20 µM 109.0 Cerep_470
MT1 (ML1A) MTNR1A Homo sapiens 20 µM 91.0 Cerep_1538
MU/H OPRM1 Homo sapiens 20 µM 103.0 Cerep_118
NA+/SITE2/R Rattus norvegicus 20 µM 107.0 Old_Cerep_169
NEUP/H SLC6A2 Homo sapiens 20 µM 94.0 Cerep_355
NK1/HUM TACR1 Homo sapiens 20 µM 95.0 Cerep_100
NK2/H TACR2 Homo sapiens 20 µM 102.0 Cerep_102
NMDA/R Rattus norvegicus 20 µM 90.0 Cerep_66
NMUSCLEH_ANTAG Homo sapiens 20 µM 120.0 Cerep_936
N_ENDOPEP MME Homo sapiens 20 µM 108.0 Old_Cerep_54
N_NEURO_A4B2 CHRNA4
 CHRNB2
 		Homo sapiens 20 µM 113.0 Cerep_3029
ORL1/H OPRL1 Homo sapiens 20 µM 91.0 Cerep_358
P38ALPHA_CE MAPK14 Homo sapiens 20 µM 113.0 Old_Cerep_61
PAF PTAFR Homo sapiens 20 µM 65.0 Cerep_4569
PCP/R Rattus norvegicus 20 µM 100.0 Old_Cerep_32
PDE2A1 PDE2A Homo sapiens 20 µM 97.0 Old_Cerep_4071
PDE3B PDE3B Homo sapiens 20 µM 95.0 Old_Cerep_4073
PDE4D2 PDE4D Homo sapiens 20 µM 82.0 Old_Cerep_4077
PDE5 Homo sapiens 20 µM 89.0 Cerep_204
PDE6_CE Bos taurus 20 µM 101.0 Cerep_478
PGI2/H PTGIR Homo sapiens 20 µM 94.0 Cerep_2230
PPARG/H AG PPARG Homo sapiens 20 µM 93.0 Cerep_641
PROTKINP55 FYN Bos taurus 20 µM 98.0 Old_Cerep_62
SIGMA/NS Homo sapiens 20 µM 99.0 Cerep_3500
SST1H_AGON SSTR1 Homo sapiens 20 µM 96.0 Cerep_1940
SST4_HU SSTR4 Homo sapiens 20 µM 146.0 Cerep_482
SUPOXXANOXID Bos taurus 20 µM 85.0 Cerep_276
TNFALPHA/H TNFRSF1A Homo sapiens 20 µM 87.0 Cerep_76
TRTH_AGON Rattus norvegicus 20 µM 129.0 Old_Cerep_55
UT1/H AG UTS2R Homo sapiens 20 µM 99.0 Cerep_1386
V1A/HUM AVPR1A Homo sapiens 20 µM 50.0 Cerep_159
V2/H AVPR2 Homo sapiens 20 µM 102.0 Cerep_497
VIP1/VPAC1/H VIPR1 Homo sapiens 20 µM 109.0 Cerep_157
Y1/HUM NPY1R Homo sapiens 20 µM 104.0 Cerep_106
ZAP70_CE ZAP70 Homo sapiens 20 µM 92.0 Old_Cerep_63
 

BI 665915

Conclusion: Clean panel at 10 µM.

Target protein HGNC name Species % control at 10 µM Mode of action Assay
5HT1A/HU HTR1A Homo sapiens 127.0 Radioactive Assay
5HT2B/HU HTR2B Homo sapiens 97.0 Radioactive Assay
5HT3/HU HTR3A Homo sapiens 102.0 Others
5HTTRANS/HU SLC6A4 Homo sapiens 106.0 Radioactive Assay
A1/HU ADORA1 Homo sapiens 75.0 Radioactive Assay
A2A/HU ADORA2A Homo sapiens 105.0
A3/H ADORA3 Homo sapiens 88.0
ALPHA1A/R ADRA1A Rattus norvegicus 100.0 Others
ALPHA1B/R ADRA1B Rattus norvegicus 96.0 Radioactive Assay
ALPHA1D/H ADRA1D Homo sapiens 107.0 Others
ALPHA2A/H ADRA2A Homo sapiens 105.0 Radioactive Assay
B1/H BDKRB1 Homo sapiens 112.0 Radioactive Assay
B2/H BDKRB2 Homo sapiens 123.0 antagonist Radioligand Binding
BETA1/HU ADRB1 Homo sapiens 103.0 Radioactive Assay
BETA2/HU ADRB2 Homo sapiens 101.0 Radioactive Assay
CA+/DHPSI/RA CACNA1C Rattus norvegicus 98.0 Radioactive Assay
CA+/DILSI/RA CACNA1C Rattus norvegicus 73.0 Radioactive Assay
CA+/N/RA CACNA1B Rattus norvegicus 95.0 Radioactive Assay
CB1 CNR1 Homo sapiens 91.0 Radioligand Binding
CYSLT1_HS CYSLTR1 Homo sapiens 100.0 Radioactive Assay
D1/HU DRD1 Homo sapiens 108.0 Radioactive Assay
D2S/HU DRD2 Homo sapiens 94.0 Radioligand Binding
D3/HU DRD3 Homo sapiens 97.0 Radioactive Assay
D4.2/H DRD4 Homo sapiens 98.0 Radioactive Assay
DATRANS/H SLC6A3 Homo sapiens 95.0 inhibitor Radioactive Assay
DELTA/HU OPRD1 Homo sapiens 96.0 Radioactive Assay
EGF/HU EGFR Homo sapiens 103.0 Radioactive Assay
ERALPHA/H ESR1 Homo sapiens 85.0 Radioactive Assay
ETA/HU EDNRA Homo sapiens 98.0 Radioactive Assay
ETB/HUM EDNRB Homo sapiens 98.0 Radioactive Assay
GABAA MUSCIMOL CENT GABRA1 Rattus norvegicus 100.0 Scintillation counting
GABAACENTR GABRA1 Rattus norvegicus 115.0 Radioactive Assay
GABATRANS/RA SLC6A1 Rattus norvegicus 82.0 Radioactive Assay
GABA_B1A GABRB1 Homo sapiens 113.0 Radioactive Assay
GLUCOCORTICO NR3C1 Homo sapiens 111.0 Radioactive Assay
H1/H HRH1 Homo sapiens 103.0 Radioactive Assay
H2/H HRH2 Homo sapiens 98.0 Radioactive Assay
H3/H HRH3 Homo sapiens 123.0 Radioactive Assay
I2/CENTR/R GNAI2 Rattus norvegicus 92.0 Radioactive Assay
IL-1 IL1B Mus musculus 99.0 Radioligand Binding
K+/HERG KCNH2 Homo sapiens 90.0 Radioactive Assay
K+/KATP/HA KCNJ1 Mullus auratus 97.0 Radioactive Assay
KAINATE/R GRIK1 Rattus norvegicus 90.0 Radioactive Assay
KAPPA/HU OPRK1 Homo sapiens 102.0 Radioactive Assay
M1/HU CHRM1 Homo sapiens 90.0 Radioactive Assay
M2/HU CHRM2 Homo sapiens 98.0 Radioactive Assay
M3/HU CHRM3 Homo sapiens 105.0 Radioactive Assay
MT1/H MTNR1A Homo sapiens 96.0 Radioactive Assay
MU/HU OPRM1 Homo sapiens 112.0 Radioactive Assay
NA+/SITE2/RA SCN1B Rattus norvegicus 84.0 Radioactive Assay
NACH/H CHRNA1 Homo sapiens 97.0 Radioligand Binding
NACH_BS_N/H CHRNA1
 CHRNB1
 		Homo sapiens 99.0 Radioactive Assay
NETRANS/H SLC6A2 Homo sapiens 103.0 Radioactive Assay
NK1/HU TACR1 Homo sapiens 104.0 Radioligand Binding
NMDAAGSI/RA Rattus norvegicus 102.0 agonist Radioactive Assay
NMDAGLSI/RA GRIN1 Rattus norvegicus 90.0 inhibitor Scintillation counting
NMDAPHSI/R GRIN2A Rattus norvegicus 111.0 Radioactive Assay
P2X/RB P2RX1 Oryctolagus cuniculus 111.0 Radioactive Assay
P2Y/RAT P2RY1 Rattus norvegicus 95.0 Radioactive Assay
PAF/H PTAFR Homo sapiens 71.0 Radioactive Assay
PEP4_HU PTGER4 Homo sapiens 92.0 Radioligand Binding
PHORBOLE/M PRKCA Mus musculus 104.0 inhibitor Radioactive Assay
SIGMA1/HU SIGMAR1 Homo sapiens 108.0 Radioactive Assay
TESTOST/RA AR Rattus norvegicus 99.0 Others
THYROID HORM THRA Rattus norvegicus 80.0 Radioactive Assay
Y1/HU NPY1R Homo sapiens 109.0 Radioactive Assay
Y2/HU NPY2R Homo sapiens 97.0 Radioactive Assay
 

BI 665915

Conclusion: Clean panel at 3 µM.

Target protein HGNC name Species % control at 3 µM Mode of action Assay
ABL1 ABL1 Homo sapiens 84.0
ABL1 E255K ABL1 Homo sapiens 82.0
ABL1 G250E ABL1 Homo sapiens 80.0
ABL1 T315I ABL1 Homo sapiens 83.0
ABL1 Y253F ABL1 Homo sapiens 80.0
ABL2 ABL2 Homo sapiens 79.5
ACVR1 ACVR1 Homo sapiens 79.0 LanthaScreen
ACVR1B ACVR1B Homo sapiens 104.0
ACVR2B ACVR2B Homo sapiens 97.0 LanthaScreen
ADRBK1 GRK2 Homo sapiens 98.5
ADRBK2 GRK3 Homo sapiens 100.5
AKT1 AKT1 Homo sapiens 99.0
AKT2 AKT2 Homo sapiens 98.0
AKT3 AKT3 Homo sapiens 101.5
ALK ALK Homo sapiens 97.0
AMPK A1B1G1 PRKAA1
 PRKAB1
 PRKAG1
 		Homo sapiens 104.0
AMPK A2B1G1 PRKAA2
 PRKAB1
 PRKAG2
 		Homo sapiens 100.0
AURKB AURKB Homo sapiens 92.0
AURKC AURKC Homo sapiens 93.0
AXL AXL Homo sapiens 95.5
BLK BLK Homo sapiens 88.5
BMPR1A(ALK3) BMPR1A Homo sapiens 87.0 LanthaScreen
BMX BMX Homo sapiens 95.0
BRAF BRAF Homo sapiens 95.0 LanthaScreen
BRAF V599E BRAF Homo sapiens 97.0 LanthaScreen
BRSK1 BRSK1 Homo sapiens 90.5
BTK BTK Homo sapiens 89.5
CAMK1D CAMK1D Homo sapiens 96.0 Z´-LYTE
CAMK1_A CAMK1 Homo sapiens 102.5 Adapta
CAMK2A CAMK2A Homo sapiens 103.0
CAMK2B CAMK2B Homo sapiens 95.0
CAMK2D CAMK2D Homo sapiens 94.5
CAMK4 CAMK4 Homo sapiens 86.0
CAMKK1 CAMKK1 Homo sapiens 102.0 LanthaScreen
CAMKK2 CAMKK2 Homo sapiens 98.0 LanthaScreen
CDC42 BPA CDC42BPA Homo sapiens 102.0
CDC42 BPB CDC42BPB Homo sapiens 94.0
CDK1/CYCLINB CDK1 Homo sapiens 99.0
CDK2/CYCLINA CDK2 Homo sapiens 100.5
CDK5/P25 CDK5 Homo sapiens 100.0
CDK5/P35 CDK5 Homo sapiens 100.5
CDK7CYCLIN CDK7 Homo sapiens 100.0 Adapta
CDK8_CYCLINC CDK8 Homo sapiens 94.0 LanthaScreen
CDK9CYCLIN CDK9 Homo sapiens 102.5 Adapta
CDK9_CYCLINK CDK9 Homo sapiens 96.0 LanthaScreen
CHEK1 CHEK1 Homo sapiens 96.0
CHEK2 CHEK2 Homo sapiens 99.0
CHUK_IKKA CHUK Homo sapiens 99.5 Adapta
CLK1 CLK1 Homo sapiens 96.5
CLK2 CLK2 Homo sapiens 95.5
CLK3 CLK3 Homo sapiens 95.5
CLK4 CLK4 Homo sapiens 95.0 LanthaScreen
CSF1R CSF1R Homo sapiens 73.0
CSK CSK Homo sapiens 95.0
CSNK1A1 CSNK1A1 Homo sapiens 96.0
CSNK1D CSNK1D Homo sapiens 97.0
CSNK1E CSNK1E Homo sapiens 95.0
CSNK1G1 CSNK1G1 Homo sapiens 97.5
CSNK1G2 CSNK1G2 Homo sapiens 98.5
CSNK1G3 CSNK1G3 Homo sapiens 99.0
CSNK2A1 CSNK2A1 Homo sapiens 97.0
CSNK2A2 CSNK2A2 Homo sapiens 94.5
DAPK1 DAPK1 Homo sapiens 99.5 Adapta
DAPK3 DAPK3 Homo sapiens 99.0
DCAMKL2 DCLK2 Homo sapiens 97.0
DDR1 DDR1 Homo sapiens 99.0 LanthaScreen
DDR2 DDR2 Homo sapiens 96.0 LanthaScreen
DMPK DMPK Homo sapiens 100.0 LanthaScreen
DNA-PK PRKDC Homo sapiens 91.0 Z´-LYTE
DYRK1A DYRK1A Homo sapiens 100.5
DYRK1B DYRK1B Homo sapiens 104.0
DYRK3 DYRK3 Homo sapiens 101.5
DYRK4 DYRK4 Homo sapiens 99.5
EEF2K EEF2K Homo sapiens 93.5
EGFR EGFR Homo sapiens 103.5
EGFR L858R EGFR Homo sapiens 96.0
EGFR L861Q EGFR Homo sapiens 98.0
EGFR T790M EGFR Homo sapiens 104.0
EGFRT790L858 EGFR Homo sapiens 101.0
EPHA1 EPHA1 Homo sapiens 89.0
EPHA2 EPHA2 Homo sapiens 99.0
EPHA3 EPHA3 Homo sapiens 92.0 LanthaScreen
EPHA4 EPHA4 Homo sapiens 95.0
EPHA5 EPHA5 Homo sapiens 92.0
EPHA7 EPHA7 Homo sapiens 78.0 LanthaScreen
EPHA8 EPHA8 Homo sapiens 98.5
EPHB1 EPHB1 Homo sapiens 93.0
EPHB2 EPHB2 Homo sapiens 93.5
EPHB3 EPHB3 Homo sapiens 97.0
EPHB4 EPHB4 Homo sapiens 101.0
ERBB2 ERBB2 Homo sapiens 108.0
ERBB4 ERBB4 Homo sapiens 98.5
FER FER Homo sapiens 98.5
FES FES Homo sapiens 94.5
FGFR1 FGFR1 Homo sapiens 100.5
FGFR2 FGFR2 Homo sapiens 89.0
FGFR3 FGFR3 Homo sapiens 95.5
FGFR3 K650E FGFR3 Homo sapiens 91.0
FGFR4 FGFR4 Homo sapiens 96.5
FGR FGR Homo sapiens 90.5
FLT1 FLT1 Homo sapiens 92.0
FLT3 FLT3 Homo sapiens 89.0
FLT3 D835Y FLT3 Homo sapiens 79.0
FLT4 FLT4 Homo sapiens 69.5
FRAP1 (MTOR) MTOR Homo sapiens 104.5
FRK FRK Homo sapiens 94.5
FYN FYN Homo sapiens 96.5
GRK4 GRK4 Homo sapiens 101.5
GRK5 GRK5 Homo sapiens 100.0
GRK6 GRK6 Homo sapiens 101.5
GRK7 GRK7 Homo sapiens 101.0
GSG2 HASPIN Homo sapiens 100.0 Adapta
GSK3A GSK3A Homo sapiens 96.0
GSK3B GSK3B Homo sapiens 95.5
HCK HCK Homo sapiens 85.0
HIPK1 HIPK1 Homo sapiens 97.0
HIPK2 HIPK2 Homo sapiens 96.0
HIPK3 HIPK3 Homo sapiens 99.0 Z´-LYTE
HIPK4 HIPK4 Homo sapiens 98.5
IGF1R IGF1R Homo sapiens 99.5
IKBKB IKBKB Homo sapiens 96.5
IKBKE IKBKE Homo sapiens 99.5
INSR INSR Homo sapiens 100.0
INSRR INSRR Homo sapiens 96.0
IRAK1 IRAK1 Homo sapiens 100.0 Adapta
IRAK4 IRAK4 Homo sapiens 102.5
ITK ITK Homo sapiens 94.0
JAK1 JAK1 Homo sapiens 100.0
JAK2 JAK2 Homo sapiens 91.0
JAK2 JH1 JH2 JAK2 Homo sapiens 92.0
JAK2 V617F JAK2 Homo sapiens 96.0
JAK3 JAK3 Homo sapiens 96.5
KDR KDR Homo sapiens 90.5
KIT KIT Homo sapiens 85.0
KIT T670I KIT Homo sapiens 93.0
KIT_V654A KIT Homo sapiens 95.0 LanthaScreen
LCK LCK Homo sapiens 91.5
LIMK1 LIMK1 Homo sapiens 96.0 LanthaScreen
LIMK2 LIMK2 Homo sapiens 89.0 LanthaScreen
LRRK2 LRRK2 Homo sapiens 96.0 Adapta
LRRK2_G2019S LRRK2 Homo sapiens 89.0 Adapta
LTK LTK Homo sapiens 96.5
LYN A LYN Homo sapiens 93.0 inhibitor FI - fluorescence intensity
LYN B LYN Homo sapiens 89.0
MAP2K1 MAP2K1 Homo sapiens 98.0 LanthaScreen
MAP2K1_S_D MAP2K1 Homo sapiens 92.0 LanthaScreen
MAP2K2 MAP2K2 Homo sapiens 96.0 LanthaScreen
MAP2K3 MAP2K3 Homo sapiens 101.0 LanthaScreen
MAP2K6 MAP2K6 Homo sapiens 103.0 LanthaScreen
MAP2K6_S_T_E MAP2K6 Homo sapiens 100.0 LanthaScreen
MAP3K10 MAP3K10 Homo sapiens 88.0 LanthaScreen
MAP3K11 MAP3K11 Homo sapiens 96.0 LanthaScreen
MAP3K14 MAP3K14 Homo sapiens 98.0 LanthaScreen
MAP3K2 MAP3K2 Homo sapiens 97.0 LanthaScreen
MAP3K3 MAP3K3 Homo sapiens 101.0 LanthaScreen
MAP3K5 MAP3K5 Homo sapiens 99.0 LanthaScreen
MAP3K7_K7IP1 MAP3K7 Homo sapiens 87.0 inhibitor LanthaScreen
MAP3K8 MAP3K8 Homo sapiens 93.5
MAP3K9 MAP3K9 Homo sapiens 91.0
MAP4K2 MAP4K2 Homo sapiens 99.5
MAP4K4 MAP4K4 Homo sapiens 96.5
MAP4K5 MAP4K5 Homo sapiens 93.0
MAPK1 MAPK1 Homo sapiens 100.0
MAPK10 MAPK10 Homo sapiens 96.0 LanthaScreen
MAPK11 MAPK11 Homo sapiens 93.0
MAPK12 MAPK12 Homo sapiens 91.5
MAPK13 MAPK13 Homo sapiens 96.5
MAPK14 MAPK14 Homo sapiens 107.0
MAPK14P38A MAPK14 Homo sapiens 100.0
MAPK3 MAPK3 Homo sapiens 97.0
MAPK8 MAPK8 Homo sapiens 93.0 LanthaScreen
MAPK9 MAPK9 Homo sapiens 101.0 LanthaScreen
MAPKAPK2 MAPKAPK2 Homo sapiens 96.5
MAPKAPK3 MAPKAPK3 Homo sapiens 98.5
MAPKAPK5 MAPKAPK5 Homo sapiens 98.5
MARK1 MARK1 Homo sapiens 98.0
MARK2 MARK2 Homo sapiens 98.5
MARK4 MARK4 Homo sapiens 103.5
MATK MATK Homo sapiens 97.5
MELK MELK Homo sapiens 94.0
MERTK MERTK Homo sapiens 94.0
MET MET Homo sapiens 97.0
MET M1250T MET Homo sapiens 105.0
MINK1 MINK1 Homo sapiens 93.0
MKNK1 MKNK1 Homo sapiens 99.0 Z´-LYTE
MKNK2 (MNK2) MKNK2 Homo sapiens 99.0 LanthaScreen
MLCK Homo sapiens 98.0 LanthaScreen
MST1R MST1R Homo sapiens 95.0
MST4 STK26 Homo sapiens 99.0
MUSK MUSK Homo sapiens 97.5
MYLK MYLK Homo sapiens 100.0 LanthaScreen
MYLK2 MYLK2 Homo sapiens 89.5
NEK1 NEK1 Homo sapiens 104.5
NEK2 NEK2 Homo sapiens 88.0
NEK4 NEK4 Homo sapiens 97.0
NEK6 NEK6 Homo sapiens 96.0
NEK7 NEK7 Homo sapiens 99.0
NEK9 NEK9 Homo sapiens 106.0
NLK NLK Homo sapiens 93.0 LanthaScreen
NTRK1 NTRK1 Homo sapiens 95.5
NTRK2 NTRK2 Homo sapiens 94.5
NTRK3 NTRK3 Homo sapiens 93.0
NUAK1 NUAK1 Homo sapiens 96.0 Adapta
PAK1 PAK1 Homo sapiens 96.0 Z´-LYTE
PAK2 PAK2 Homo sapiens 100.5
PAK3 PAK3 Homo sapiens 94.5
PAK4 PAK4 Homo sapiens 93.5
PAK6 PAK6 Homo sapiens 93.5
PAK7 PAK5 Homo sapiens 97.0
PASK PASK Homo sapiens 100.5
PDGFRA PDGFRA Homo sapiens 86.0
PDGFRA D842V PDGFRA Homo sapiens 95.0
PDGFRA T674I PDGFRA Homo sapiens 87.0
PDGFRA V561D PDGFRA Homo sapiens 85.0
PDGFRB PDGFRB Homo sapiens 94.5
PDK1 PDK1 Homo sapiens 92.0
PDK1DIRECT PDK1 Homo sapiens 97.0 Z´-LYTE
PHKG1 PHKG1 Homo sapiens 97.5
PHKG2 PHKG2 Homo sapiens 97.5
PI4KA PI4KA Homo sapiens 106.0 Adapta
PI4KB PI4KB Homo sapiens 95.0 Adapta
PIK3C2A PIK3C2A Homo sapiens 103.5 Adapta
PIK3C2B PIK3C2B Homo sapiens 108.0 Adapta
PIK3C3 PIK3C3 Homo sapiens 94.5 Adapta
PIK3CAPIK3R1 PIK3CA
 PIK3R1
 		Homo sapiens 104.0 Adapta
PIK3CDPIK3R1 PIK3CD
 PIK3R1
 		Homo sapiens 99.5 inhibitor Adapta
PIK3CG PIK3CG Homo sapiens 104.0 Adapta
PIM1 PIM1 Homo sapiens 97.5
PIM2 PIM2 Homo sapiens 101.0
PKN1 PKN1 Homo sapiens 98.5
PLK1 PLK1 Homo sapiens 97.0
PLK2 PLK2 Homo sapiens 90.0
PLK3 PLK3 Homo sapiens 98.0
PRKACA PRKACA Homo sapiens 103.5
PRKCA PRKCA Homo sapiens 101.5
PRKCB1 PRKCB Homo sapiens 98.5
PRKCB2 PRKCB Homo sapiens 100.0
PRKCD PRKCD Homo sapiens 103.0
PRKCE PRKCE Homo sapiens 86.5
PRKCG PRKCG Homo sapiens 100.5
PRKCH PRKCH Homo sapiens 86.0
PRKCI PRKCI Homo sapiens 97.0
PRKCN PRKD3 Homo sapiens 94.5
PRKCQ PRKCQ Homo sapiens 93.5
PRKCZ PRKCZ Homo sapiens 100.0
PRKD1 PRKD1 Homo sapiens 92.0
PRKD2 PRKD2 Homo sapiens 95.0
PRKG1 PRKG1 Homo sapiens 101.5
PRKG2 PRKG2 Homo sapiens 92.5
PRKX PRKX Homo sapiens 101.5
PTK2 PTK2 Homo sapiens 87.5
PTK2B PTK2B Homo sapiens 86.0
PTK6 PTK6 Homo sapiens 99.5
RAF1 RAF1 Homo sapiens 97.0 Z´-LYTE
RAF1_Y_D RAF1 Homo sapiens 98.0 LanthaScreen
RET RET Homo sapiens 56.0
RET V804L RET Homo sapiens 72.0
RET Y791F RET Homo sapiens 60.0
RIPK2 RIPK2 Homo sapiens 91.0 LanthaScreen
ROCK1 ROCK1 Homo sapiens 99.5
ROCK2 ROCK2 Homo sapiens 102.0
ROS1 ROS1 Homo sapiens 97.5
RPS6KA1 RPS6KA1 Homo sapiens 96.0
RPS6KA2 RPS6KA2 Homo sapiens 100.0
RPS6KA3 RPS6KA3 Homo sapiens 105.0
RPS6KA4 RPS6KA4 Homo sapiens 103.0
RPS6KA5 RPS6KA5 Homo sapiens 97.5
RPS6KA6 RPS6KA6 Homo sapiens 105.0
RPS6KB1 RPS6KB1 Homo sapiens 97.5
SGK SGK1 Homo sapiens 99.0
SGK2 SGK2 Homo sapiens 97.0
SGKL SGK3 Homo sapiens 101.0
SLK SLK Homo sapiens 99.0 LanthaScreen
SNF1LK2 SIK2 Homo sapiens 97.5 inhibitor Z´-LYTE
SPHK1 SPHK1 Homo sapiens 95.5 Adapta
SPHK2 SPHK2 Homo sapiens 97.0 Adapta
SRC SRC Homo sapiens 90.5
SRC N1 SRC Homo sapiens 85.0
SRMS SRMS Homo sapiens 98.5
SRPK1 SRPK1 Homo sapiens 97.5
SRPK2 SRPK2 Homo sapiens 98.0
STK16 STK16 Homo sapiens 98.0 LanthaScreen
STK17A STK17A Homo sapiens 96.0 LanthaScreen
STK22B TSSK2 Homo sapiens 93.0
STK22D TSSK3 Homo sapiens 96.5
STK23 SRPK3 Homo sapiens 96.5
STK24 STK24 Homo sapiens 100.5
STK25 STK25 Homo sapiens 106.0
STK3 STK3 Homo sapiens 104.0
STK33 STK33 Homo sapiens 101.0 LanthaScreen
STK4 STK4 Homo sapiens 99.0
STK6 AURKA Homo sapiens 75.5 Z´-LYTE
SYK SYK Homo sapiens 90.0
TAOK2 TAOK2 Homo sapiens 100.5
TAOK3 TAOK3 Homo sapiens 104.0 LanthaScreen
TBK1 TBK1 Homo sapiens 92.0
TEC TEC Homo sapiens 103.0 LanthaScreen
TEK TEK Homo sapiens 97.0
TGFBR1 TGFBR1 Homo sapiens 96.0 LanthaScreen
TNK2 TNK2 Homo sapiens 99.0 LanthaScreen
TTK TTK Homo sapiens 98.0 LanthaScreen
TXK TXK Homo sapiens 95.0 Z´-LYTE
TYK2 TYK2 Homo sapiens 97.5
TYRO3 TYRO3 Homo sapiens 96.5
WEE1 WEE1 Homo sapiens 100.0 LanthaScreen
WNK2 WNK2 Homo sapiens 96.0 LanthaScreen
YES1 YES1 Homo sapiens 88.5
ZAK MAP3K20 Homo sapiens 97.0 LanthaScreen
ZAP70 ZAP70 Homo sapiens 96.0
MARK3 MARK3 Homo sapiens 98.0 Z´-LYTE