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Selectivity data for probe MRL-SYKi and control MRL-SYKi-NC


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MRL-SYKi


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A -0.08
5-HT1B HTR1B 11.61
5-HT1D HTR1D 2.65
5-HT1E HTR1E 11.39
5-HT2A HTR2A -4.23
5-HT2B HTR2B 6.38
5-HT2C HTR2C 3.02
5-HT3 HTR3A -3.84
5-HT5A HTR5A 10.01
5-HT6 HTR6 -12.22
5-HT7A HTR7 -15.24
D1 DRD1 -7.40
D2 DRD2 -3.52
D3 DRD3 -5.53
D4 DRD4 -6.05
D5 DRD5 8.85
SERT SLC6A4 3.34
NET SLC6A2 -24.32 7713.00 5.10
DAT SLC6A3 39.29
MOR OPRM1 17.30
DOR OPRD1 12.82
KOR OPRK1 30.61
GABAA -2.68
H1 HRH1 7.85
H2 HRH2 3.06
H3 HRH3 50.40 > 10000.00 < 5.00
H4 HRH4 7.61
Alpha1A ADRA1A -16.93
Alpha1B ADRA1B 3.23
Alpha2A ADRA2A -2.14
Alpha2B ADRA2B -7.14
Alpha2C ADRA2C -3.94
Beta1 ADRB1 -9.08
Beta2 ADRB2 5.53
M1 CHRM1 -13.70
M2 CHRM2 8.60
M3 CHRM3 17.37
M4 CHRM4 16.71
M5 CHRM5 0.94
Beta3 ADRB3 3.43
GABAA/BZP 25.89
GABA/PBR 3.63
Alpha1D ADRA1D -4.92
Sigma 2 TMEM97 33.55
Sigma 1 SIGMAR1 -22.93

MRL-SYKi-NC


Compound concentration: 10 µM
Receptor HGNC target name Inhibition [%] (Primary experimental value) Ki [nM] (Secondary experimental value) pKi
5-HT1A HTR1A 17.48
5-HT1B HTR1B 20.16
5-HT1D HTR1D 16.51
5-HT1E HTR1E -12.05
5-HT2A HTR2A 11.18
5-HT2B HTR2B 77.94 1058.00 5.98
5-HT2C HTR2C 4.21
5-HT3 HTR3A -1.96
5-HT5A HTR5A -4.56
5-HT6 HTR6 6.66
5-HT7A HTR7 -16.39
D1 DRD1 6.27
D2 DRD2 -5.34
D3 DRD3 -8.44
D4 DRD4 -9.54
D5 DRD5 18.60
SERT SLC6A4 15.65
NET SLC6A2 -19.65
DAT SLC6A3 70.97 > 10000.00 < 5.00
MOR OPRM1 8.33
DOR OPRD1 25.12
KOR OPRK1 -5.83
GABAA 20.31
H1 HRH1 9.09
H2 HRH2 8.65
H3 HRH3 46.35
H4 HRH4 8.06
Alpha1A ADRA1A -13.66
Alpha1B ADRA1B 7.90
Alpha2A ADRA2A 34.45
Alpha2B ADRA2B 27.01
Alpha2C ADRA2C 11.85
Beta1 ADRB1 10.28
Beta2 ADRB2 1.60
M1 CHRM1 -6.43
M2 CHRM2 22.96
M3 CHRM3 6.69
M4 CHRM4 19.97
M5 CHRM5 -4.28
Beta3 ADRB3 -6.54
GABAA/BZP 19.02
GABA/PBR 71.83 774.00 6.11
Alpha1D ADRA1D -2.32
Sigma 2 TMEM97 27.38
Sigma 1 SIGMAR1 -11.39

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Primary results are shown as '% Ctrl', i.e. the negative control (DMSO) is equal 100% control and the positive control (control compound) is equal 0% control. For compounds showing less than 50% of control in the primary screening assay, a Kd will be determined. Note: It cannot be excluded that 0 % control values are due to assay artefacts.
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MRL-SYKi


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 100.0 100
ABL1 ABL1-phosphorylated 63.3 100
ABL2 ABL2 85.8 100
ACVR1 ACVR1 59.3 100
ACVR1B ACVR1B 92.7 100
ACVR2A ACVR2A 85.6 100
ACVR2B ACVR2B 82.8 100
ACVRL1 ACVRL1 66.5 100
COQ8A ADCK3 100.0 100
COQ8B ADCK4 99.4 100
AKT1 AKT1 100.0 100
AKT2 AKT2 100.0 100
AKT3 AKT3 100.0 100
ALK ALK(L1196M) 100.0 100
PRKAA1 AMPK-alpha1 100.0 100
PRKAA2 AMPK-alpha2 100.0 100
ANKK1 ANKK1 100.0 100
NUAK1 ARK5 100.0 100
MAP3K5 ASK1 83.3 100
MAP3K6 ASK2 69.5 100
AURKA AURKA 100.0 100
AURKB AURKB 89.0 100
AURKC AURKC 100.0 100
AXL AXL 100.0 100
BMP2K BIKE 100.0 100
BLK BLK 74.6 100
BMPR1A BMPR1A 90.5 100
BMPR1B BMPR1B 100.0 100
BMPR2 BMPR2 100.0 100
BMX BMX 95.1 100
BRAF BRAF(V600E) 100.0 100
PTK6 BRK 100.0 100
BRSK1 BRSK1 100.0 100
BRSK2 BRSK2 100.0 100
BTK BTK 81.5 100
BUB1 BUB1 100.0 100
CAMK1 CAMK1 99.3 100
PNCK CAMK1B 78.1 100
CAMK1D CAMK1D 97.1 100
CAMK1G CAMK1G 100.0 100
CAMK2A CAMK2A 100.0 100
CAMK2B CAMK2B 100.0 100
CAMK2D CAMK2D 84.6 100
CAMK2G CAMK2G 95.2 100
CAMK4 CAMK4 92.3 100
CAMKK1 CAMKK1 66.6 100
CAMKK2 CAMKK2 69.7 100
CASK CASK 64.9 100
CDK11B CDC2L1 93.3 100
CDK11A CDC2L2 86.1 100
CDK13 CDC2L5 89.5 100
CDK19 CDK11 85.0 100
CDK2 CDK2 94.7 100
CDK3 CDK3 100.0 100
CDK4 CDK4-cyclinD3 100.0 100
CDK5 CDK5 87.6 100
CDK7 CDK7 100.0 100
CDK8 CDK8 100.0 100
CDK9 CDK9 100.0 100
CDKL1 CDKL1 78.8 100
CDKL2 CDKL2 89.6 100
CDKL3 CDKL3 100.0 100
CDKL5 CDKL5 96.1 100
CHEK1 CHEK1 100.0 100
CHEK2 CHEK2 100.0 100
CIT CIT 100.0 100
CLK1 CLK1 97.9 100
CLK2 CLK2 98.0 100
CLK3 CLK3 100.0 100
CLK4 CLK4 90.9 100
CSF1R CSF1R-autoinhibited 85.6 100
CSK CSK 100.0 100
CSNK1A1 CSNK1A1 61.6 100
CSNK1A1L CSNK1A1L 100.0 100
CSNK1D CSNK1D 100.0 100
CSNK1E CSNK1E 100.0 100
CSNK1G1 CSNK1G1 100.0 100
CSNK1G2 CSNK1G2 94.5 100
CSNK1G3 CSNK1G3 99.9 100
CSNK2A1 CSNK2A1 100.0 100
CSNK2A2 CSNK2A2 100.0 100
MATK CTK 100.0 100
DAPK1 DAPK1 100.0 100
DAPK2 DAPK2 100.0 100
DAPK3 DAPK3 100.0 100
DCLK1 DCAMKL1 64.1 100
DCLK2 DCAMKL2 90.1 100
DCLK3 DCAMKL3 97.3 100
DDR1 DDR1 84.5 100
DDR2 DDR2 100.0 100
MAP3K12 DLK 66.9 100
DMPK DMPK 99.8 100
CDC42BPG DMPK2 93.6 100
STK17A DRAK1 99.6 100
STK17B DRAK2 100.0 100
DYRK1A DYRK1A 100.0 100
DYRK1B DYRK1B 69.4 100
DYRK2 DYRK2 100.0 100
EGFR EGFR(T790M) 91.6 100
EIF2AK1 EIF2AK1 100.0 100
EPHA1 EPHA1 100.0 100
EPHA2 EPHA2 100.0 100
EPHA3 EPHA3 100.0 100
EPHA4 EPHA4 78.6 100
EPHA5 EPHA5 94.0 100
EPHA6 EPHA6 95.8 100
EPHA7 EPHA7 81.3 100
EPHA8 EPHA8 100.0 100
EPHB1 EPHB1 100.0 100
EPHB2 EPHB2 100.0 100
EPHB3 EPHB3 100.0 100
EPHB4 EPHB4 100.0 100
EPHB6 EPHB6 34.7 100
ERBB2 ERBB2 89.6 100
ERBB3 ERBB3 66.6 100
ERBB4 ERBB4 81.9 100
MAPK3 ERK1 98.9 100
MAPK1 ERK2 100.0 100
MAPK6 ERK3 97.9 100
MAPK4 ERK4 100.0 100
MAPK7 ERK5 83.6 100
MAPK15 ERK8 100.0 100
ERN1 ERN1 90.2 100
PTK2 FAK 99.9 100
FER FER 100.0 100
FES FES 100.0 100
FGFR1 FGFR1 82.0 100
FGFR2 FGFR2 67.3 100
FGFR3 FGFR3(G697C) 100.0 100
FGFR4 FGFR4 100.0 100
FGR FGR 100.0 100
FLT1 FLT1 100.0 100
FLT3 FLT3-autoinhibited 100.0 100
FLT4 FLT4 91.3 100
FRK FRK 100.0 100
FYN FYN 36.1 100
GAK GAK 100.0 100
EIF2AK4 GCN2(Kin.Dom.2,S808G) 56.2 100
GRK1 GRK1 71.7 100
GRK2 GRK2 97.5 100
GRK3 GRK3 73.7 100
GRK4 GRK4 100.0 100
GRK7 GRK7 100.0 100
GSK3A GSK3A 100.0 100
GSK3B GSK3B 100.0 100
HASPIN HASPIN 90.8 100
HCK HCK 83.3 100
HIPK1 HIPK1 52.3 100
HIPK2 HIPK2 83.5 100
HIPK3 HIPK3 87.3 100
HIPK4 HIPK4 75.6 100
MAP4K1 HPK1 100.0 100
HUNK HUNK 100.0 100
CILK1 ICK 65.4 100
IGF1R IGF1R 100.0 100
CHUK IKK-alpha 100.0 100
IKBKB IKK-beta 100.0 100
IKBKE IKK-epsilon 100.0 100
INSR INSR 100.0 100
INSRR INSRR 100.0 100
IRAK1 IRAK1 80.7 100
IRAK3 IRAK3 44.7 100
IRAK4 IRAK4 100.0 100
ITK ITK 81.0 100
JAK1 JAK1(JH2domain-pseudokinase) 31.8 100
JAK2 JAK2(JH1domain-catalytic) 45.5 100
JAK3 JAK3(JH1domain-catalytic) 60.9 100
MAPK8 JNK1 46.6 100
MAPK9 JNK2 100.0 100
MAPK10 JNK3 67.7 100
KIT KIT-autoinhibited 71.7 100
LATS1 LATS1 100.0 100
LATS2 LATS2 100.0 100
LCK LCK 73.0 100
LIMK1 LIMK1 93.1 100
LIMK2 LIMK2 87.2 100
STK11 LKB1 100.0 100
STK10 LOK 100.0 100
LRRK2 LRRK2(G2019S) 92.3 100
LTK LTK 100.0 100
LYN LYN 100.0 100
MAP3K13 LZK 100.0 100
MAK MAK 73.8 100
MAP3K1 MAP3K1 100.0 100
MAP3K15 MAP3K15 80.5 100
MAP3K2 MAP3K2 100.0 100
MAP3K3 MAP3K3 100.0 100
MAP3K4 MAP3K4 67.4 100
MAP4K2 MAP4K2 100.0 100
MAP4K3 MAP4K3 100.0 100
MAP4K4 MAP4K4 100.0 100
MAP4K5 MAP4K5 95.4 100
MAPKAPK2 MAPKAPK2 100.0 100
MAPKAPK5 MAPKAPK5 100.0 100
MARK1 MARK1 95.3 100
MARK2 MARK2 100.0 100
MARK3 MARK3 100.0 100
MARK4 MARK4 100.0 100
MAST1 MAST1 100.0 100
MAP2K1 MEK1 100.0 100
MAP2K2 MEK2 89.4 100
MAP2K3 MEK3 29.5 100
MAP2K4 MEK4 100.0 100
MAP2K5 MEK5 25.2 100
MAP2K6 MEK6 100.0 100
MELK MELK 88.0 100
MERTK MERTK 81.5 100
MET MET(Y1235D) 89.9 100
MINK1 MINK 80.7 100
MAP2K7 MKK7 90.3 100
MKNK1 MKNK1 94.8 100
MKNK2 MKNK2 74.7 100
MYLK3 MLCK 100.0 100
MAP3K9 MLK1 90.4 100
MAP3K10 MLK2 95.1 100
MAP3K11 MLK3 92.6 100
CDC42BPA MRCKA 86.2 100
CDC42BPB MRCKB 100.0 100
STK4 MST1 100.0 100
MST1R MST1R 65.9 100
STK3 MST2 100.0 100
STK24 MST3 83.5 100
STK26 MST4 100.0 100
MTOR MTOR 77.7 100
MUSK MUSK 100.0 100
MYLK MYLK 92.9 100
MYLK2 MYLK2 100.0 100
MYLK4 MYLK4 100.0 100
MYO3A MYO3A 100.0 100
MYO3B MYO3B 76.1 100
STK38 NDR1 80.6 100
STK38L NDR2 100.0 100
NEK1 NEK1 100.0 100
NEK10 NEK10 53.1 100
NEK11 NEK11 61.2 100
NEK2 NEK2 100.0 100
NEK3 NEK3 50.7 100
NEK4 NEK4 96.6 100
NEK5 NEK5 74.2 100
NEK6 NEK6 100.0 100
NEK7 NEK7 92.9 100
NEK9 NEK9 92.8 100
MAP3K14 NIK 89.0 100
NIM1K NIM1 100.0 100
NLK NLK 73.0 100
OXSR1 OSR1 79.9 100
MAPK14 p38-alpha 100.0 100
MAPK11 p38-beta 100.0 100
MAPK13 p38-delta 97.9 100
MAPK12 p38-gamma 31.2 100
PAK1 PAK1 100.0 100
PAK2 PAK2 100.0 100
PAK3 PAK3 100.0 100
PAK4 PAK4 89.8 100
PAK6 PAK6 100.0 100
PAK5 PAK7 100.0 100
CDK16 PCTK1 100.0 100
CDK17 PCTK2 73.2 100
CDK18 PCTK3 100.0 100
PDGFRA PDGFRA 100.0 100
PDGFRB PDGFRB 100.0 100
PDPK1 PDPK1 86.5 100
CDPK1 PFCDPK1(P.falciparum) 100.0 100
PK5 PFPK5(P.falciparum) 100.0 100
CDK15 PFTAIRE2 100.0 100
CDK14 PFTK1 100.0 100
PHKG1 PHKG1 100.0 100
PHKG2 PHKG2 100.0 100
PIK3C2B PIK3C2B 100.0 100
PIK3C2G PIK3C2G 95.9 100
PIK3CA PIK3CA(Q546K) 81.6 100
PIK3CB PIK3CB 100.0 100
PIK3CD PIK3CD 100.0 100
PIK3CG PIK3CG 100.0 100
PI4KB PIK4CB 88.6 100
PIKFYVE PIKFYVE 98.7 100
PIM1 PIM1 91.7 100
PIM2 PIM2 100.0 100
PIM3 PIM3 100.0 100
PIP5K1A PIP5K1A 100.0 100
PIP5K1C PIP5K1C 92.4 100
PIP4K2B PIP5K2B 79.6 100
PIP4K2C PIP5K2C 91.9 100
PRKACA PKAC-alpha 100.0 100
PRKACB PKAC-beta 100.0 100
PKMYT1 PKMYT1 100.0 100
PKN1 PKN1 96.9 100
PKN2 PKN2 100.0 100
PKNB PKNB(M.tuberculosis) 100.0 100
PLK1 PLK1 100.0 100
PLK2 PLK2 100.0 100
PLK3 PLK3 74.6 100
PLK4 PLK4 100.0 100
PRKCD PRKCD 83.7 100
PRKCE PRKCE 100.0 100
PRKCH PRKCH 97.5 100
PRKCI PRKCI 77.3 100
PRKCQ PRKCQ 39.9 100
PRKD1 PRKD1 100.0 100
PRKD2 PRKD2 96.1 100
PRKD3 PRKD3 100.0 100
PRKG1 PRKG1 100.0 100
PRKG2 PRKG2 100.0 100
EIF2AK2 PRKR 77.4 100
PRKX PRKX 100.0 100
PRPF4B PRP4 90.3 100
PTK2B PYK2 100.0 100
SIK3 QSK 100.0 100
RAF1 RAF1 100.0 100
RET RET(V804M) 81.3 100
RIOK1 RIOK1 100.0 100
RIOK2 RIOK2 83.9 100
RIOK3 RIOK3 77.2 100
RIPK1 RIPK1 87.1 100
RIPK2 RIPK2 83.8 100
RIPK4 RIPK4 91.9 100
DSTYK RIPK5 100.0 100
ROCK1 ROCK1 70.7 100
ROCK2 ROCK2 85.9 100
ROS1 ROS1 97.0 100
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 83.4 100
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 86.0 100
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 77.2 100
RPS6KB1 S6K1 78.2 100
SBK1 SBK1 100.0 100
SGK1 SGK 100.0 100
SBK3 SgK110 100.0 100
SGK2 SGK2 100.0 100
SGK3 SGK3 100.0 100
SIK1 SIK 94.3 100
SIK2 SIK2 95.7 100
SLK SLK 96.4 100
NUAK2 SNARK 100.0 100
SNRK SNRK 100.0 100
SRC SRC 53.7 100
SRMS SRMS 81.2 100
SRPK1 SRPK1 97.7 100
SRPK2 SRPK2 100.0 100
SRPK3 SRPK3 100.0 100
STK16 STK16 100.0 100
STK33 STK33 64.4 100
STK35 STK35 100.0 100
STK36 STK36 94.5 100
STK39 STK39 81.8 100
SYK SYK 0.9 100 = 1.8
MAP3K7 TAK1 100.0 100
TAOK1 TAOK1 100.0 100
TAOK2 TAOK2 97.5 100
TAOK3 TAOK3 100.0 100
TBK1 TBK1 55.5 100
TEC TEC 75.2 100
TESK1 TESK1 100.0 100
TGFBR1 TGFBR1 68.4 100
TGFBR2 TGFBR2 49.5 100
TIE1 TIE1 68.1 100
TEK TIE2 99.0 100
TLK1 TLK1 100.0 100
TLK2 TLK2 100.0 100
TNIK TNIK 100.0 100
TNK1 TNK1 100.0 100
TNK2 TNK2 100.0 100
TNNI3K TNNI3K 100.0 100
NTRK1 TRKA 30.2 100
NTRK2 TRKB 60.3 100
NTRK3 TRKC 82.6 100
TRPM6 TRPM6 94.8 100
TSSK1B TSSK1B 100.0 100
TSSK3 TSSK3 100.0 100
TTK TTK 74.8 100
TXK TXK 64.0 100
TYK2 TYK2(JH2domain-pseudokinase) 100.0 100
TYRO3 TYRO3 60.2 100
ULK1 ULK1 100.0 100
ULK2 ULK2 100.0 100
ULK3 ULK3 56.1 100
KDR VEGFR2 100.0 100
PIK3C3 VPS34 99.6 100
VRK2 VRK2 100.0 100
WEE1 WEE1 93.1 100
WEE2 WEE2 100.0 100
WNK1 WNK1 100.0 100
WNK2 WNK2 81.2 100
WNK3 WNK3 100.0 100
WNK4 WNK4 100.0 100
STK32A YANK1 100.0 100
STK32B YANK2 100.0 100
STK32C YANK3 85.9 100
YES1 YES 100.0 100
STK25 YSK1 100.0 100
MAP3K19 YSK4 100.0 100
MAP3K20 ZAK 92.5 100
ZAP70 ZAP70 44.9 100

MRL-SYKi-NC


HGNC target name DiscoverX gene symbol of kinase % Control Compound Concentration [nM] Kd [nM]
AAK1 AAK1 85.7 100
ABL1 ABL1-phosphorylated 100.0 100
ABL2 ABL2 98.3 100
ACVR1 ACVR1 100.0 100
ACVR1B ACVR1B 100.0 100
ACVR2A ACVR2A 96.9 100
ACVR2B ACVR2B 100.0 100
ACVRL1 ACVRL1 100.0 100
COQ8A ADCK3 100.0 100
COQ8B ADCK4 98.7 100
AKT1 AKT1 92.3 100
AKT2 AKT2 100.0 100
AKT3 AKT3 82.8 100
ALK ALK(L1196M) 100.0 100
PRKAA1 AMPK-alpha1 77.6 100
PRKAA2 AMPK-alpha2 94.7 100
ANKK1 ANKK1 93.5 100
NUAK1 ARK5 100.0 100
MAP3K5 ASK1 100.0 100
MAP3K6 ASK2 100.0 100
AURKA AURKA 60.2 100
AURKB AURKB 93.1 100
AURKC AURKC 100.0 100
AXL AXL 100.0 100
BMP2K BIKE 100.0 100
BLK BLK 100.0 100
BMPR1A BMPR1A 100.0 100
BMPR1B BMPR1B 92.3 100
BMPR2 BMPR2 54.9 100
BMX BMX 100.0 100
BRAF BRAF(V600E) 100.0 100
PTK6 BRK 100.0 100
BRSK1 BRSK1 100.0 100
BRSK2 BRSK2 60.7 100
BTK BTK 86.1 100
BUB1 BUB1 100.0 100
CAMK1 CAMK1 75.3 100
PNCK CAMK1B 95.9 100
CAMK1D CAMK1D 89.6 100
CAMK1G CAMK1G 90.7 100
CAMK2A CAMK2A 90.8 100
CAMK2B CAMK2B 95.3 100
CAMK2D CAMK2D 87.2 100
CAMK2G CAMK2G 88.2 100
CAMK4 CAMK4 100.0 100
CAMKK1 CAMKK1 84.1 100
CAMKK2 CAMKK2 91.5 100
CASK CASK 100.0 100
CDK11B CDC2L1 95.4 100
CDK11A CDC2L2 100.0 100
CDK13 CDC2L5 45.7 100
CDK19 CDK11 95.3 100
CDK2 CDK2 98.8 100
CDK3 CDK3 92.9 100
CDK4 CDK4-cyclinD3 93.4 100
CDK5 CDK5 100.0 100
CDK7 CDK7 86.2 100
CDK8 CDK8 78.7 100
CDK9 CDK9 100.0 100
CDKL1 CDKL1 75.6 100
CDKL2 CDKL2 94.3 100
CDKL3 CDKL3 100.0 100
CDKL5 CDKL5 100.0 100
CHEK1 CHEK1 100.0 100
CHEK2 CHEK2 100.0 100
CIT CIT 90.9 100
CLK1 CLK1 83.8 100
CLK2 CLK2 100.0 100
CLK3 CLK3 76.0 100
CLK4 CLK4 65.2 100
CSF1R CSF1R-autoinhibited 84.0 100
CSK CSK 82.3 100
CSNK1A1 CSNK1A1 94.0 100
CSNK1A1L CSNK1A1L 91.9 100
CSNK1D CSNK1D 92.5 100
CSNK1E CSNK1E 87.6 100
CSNK1G1 CSNK1G1 91.8 100
CSNK1G2 CSNK1G2 100.0 100
CSNK1G3 CSNK1G3 89.1 100
CSNK2A1 CSNK2A1 100.0 100
CSNK2A2 CSNK2A2 59.8 100
MATK CTK 74.6 100
DAPK1 DAPK1 100.0 100
DAPK2 DAPK2 84.8 100
DAPK3 DAPK3 92.7 100
DCLK1 DCAMKL1 91.3 100
DCLK2 DCAMKL2 100.0 100
DCLK3 DCAMKL3 76.2 100
DDR1 DDR1 100.0 100
DDR2 DDR2 100.0 100
MAP3K12 DLK 99.3 100
DMPK DMPK 93.7 100
CDC42BPG DMPK2 100.0 100
STK17A DRAK1 96.7 100
STK17B DRAK2 94.6 100
DYRK1A DYRK1A 81.4 100
DYRK1B DYRK1B 97.4 100
DYRK2 DYRK2 82.4 100
EGFR EGFR(T790M) 77.8 100
EIF2AK1 EIF2AK1 83.4 100
EPHA1 EPHA1 100.0 100
EPHA2 EPHA2 100.0 100
EPHA3 EPHA3 93.7 100
EPHA4 EPHA4 100.0 100
EPHA5 EPHA5 100.0 100
EPHA6 EPHA6 100.0 100
EPHA7 EPHA7 94.2 100
EPHA8 EPHA8 88.9 100
EPHB1 EPHB1 98.7 100
EPHB2 EPHB2 100.0 100
EPHB3 EPHB3 100.0 100
EPHB4 EPHB4 100.0 100
EPHB6 EPHB6 78.6 100
ERBB2 ERBB2 100.0 100
ERBB3 ERBB3 100.0 100
ERBB4 ERBB4 81.2 100
MAPK3 ERK1 100.0 100
MAPK1 ERK2 100.0 100
MAPK6 ERK3 100.0 100
MAPK4 ERK4 100.0 100
MAPK7 ERK5 100.0 100
MAPK15 ERK8 80.3 100
ERN1 ERN1 68.6 100
PTK2 FAK 90.2 100
FER FER 95.4 100
FES FES 100.0 100
FGFR1 FGFR1 92.4 100
FGFR2 FGFR2 100.0 100
FGFR3 FGFR3(G697C) 100.0 100
FGFR4 FGFR4 100.0 100
FGR FGR 100.0 100
FLT1 FLT1 97.7 100
FLT3 FLT3-autoinhibited 100.0 100
FLT4 FLT4 100.0 100
FRK FRK 100.0 100
FYN FYN 100.0 100
GAK GAK 100.0 100
EIF2AK4 GCN2(Kin.Dom.2,S808G) 100.0 100
GRK1 GRK1 82.1 100
GRK2 GRK2 100.0 100
GRK3 GRK3 98.3 100
GRK4 GRK4 100.0 100
GRK7 GRK7 75.4 100
GSK3A GSK3A 86.8 100
GSK3B GSK3B 95.6 100
HASPIN HASPIN 47.0 100
HCK HCK 71.9 100
HIPK1 HIPK1 84.8 100
HIPK2 HIPK2 73.5 100
HIPK3 HIPK3 88.3 100
HIPK4 HIPK4 97.7 100
MAP4K1 HPK1 100.0 100
HUNK HUNK 96.2 100
CILK1 ICK 91.7 100
IGF1R IGF1R 100.0 100
CHUK IKK-alpha 69.7 100
IKBKB IKK-beta 43.1 100
IKBKE IKK-epsilon 73.8 100
INSR INSR 78.7 100
INSRR INSRR 86.1 100
IRAK1 IRAK1 49.8 100
IRAK3 IRAK3 93.0 100
IRAK4 IRAK4 48.8 100
ITK ITK 94.7 100
JAK1 JAK1(JH2domain-pseudokinase) 92.6 100
JAK2 JAK2(JH1domain-catalytic) 96.6 100
JAK3 JAK3(JH1domain-catalytic) 42.0 100
MAPK8 JNK1 63.7 100
MAPK9 JNK2 45.3 100
MAPK10 JNK3 37.5 100
KIT KIT-autoinhibited 100.0 100
LATS1 LATS1 100.0 100
LATS2 LATS2 90.6 100
LCK LCK 100.0 100
LIMK1 LIMK1 100.0 100 > 10000.0
LIMK2 LIMK2 100.0 100
STK11 LKB1 70.8 100
STK10 LOK 74.5 100
LRRK2 LRRK2(G2019S) 64.9 100
LTK LTK 75.8 100
LYN LYN 100.0 100
MAP3K13 LZK 100.0 100
MAK MAK 93.9 100
MAP3K1 MAP3K1 96.0 100
MAP3K15 MAP3K15 85.0 100
MAP3K2 MAP3K2 100.0 100
MAP3K3 MAP3K3 82.5 100
MAP3K4 MAP3K4 100.0 100
MAP4K2 MAP4K2 100.0 100
MAP4K3 MAP4K3 100.0 100
MAP4K4 MAP4K4 100.0 100
MAP4K5 MAP4K5 95.4 100
MAPKAPK2 MAPKAPK2 97.9 100
MAPKAPK5 MAPKAPK5 97.7 100
MARK1 MARK1 62.8 100
MARK2 MARK2 100.0 100
MARK3 MARK3 100.0 100
MARK4 MARK4 71.5 100
MAST1 MAST1 100.0 100
MAP2K1 MEK1 95.0 100
MAP2K2 MEK2 87.0 100
MAP2K3 MEK3 90.0 100
MAP2K4 MEK4 81.2 100
MAP2K5 MEK5 85.2 100
MAP2K6 MEK6 89.3 100
MELK MELK 100.0 100
MERTK MERTK 100.0 100
MET MET(Y1235D) 77.3 100
MINK1 MINK 100.0 100
MAP2K7 MKK7 77.8 100
MKNK1 MKNK1 75.0 100
MKNK2 MKNK2 100.0 100
MYLK3 MLCK 90.9 100
MAP3K9 MLK1 100.0 100
MAP3K10 MLK2 69.4 100
MAP3K11 MLK3 100.0 100
CDC42BPA MRCKA 100.0 100
CDC42BPB MRCKB 91.6 100
STK4 MST1 69.1 100
MST1R MST1R 100.0 100
STK3 MST2 98.1 100
STK24 MST3 100.0 100
STK26 MST4 100.0 100
MTOR MTOR 84.6 100
MUSK MUSK 93.6 100
MYLK MYLK 86.6 100
MYLK2 MYLK2 90.9 100
MYLK4 MYLK4 100.0 100
MYO3A MYO3A 70.1 100
MYO3B MYO3B 100.0 100
STK38 NDR1 87.9 100
STK38L NDR2 100.0 100
NEK1 NEK1 67.1 100
NEK10 NEK10 97.3 100
NEK11 NEK11 93.0 100
NEK2 NEK2 100.0 100
NEK3 NEK3 82.8 100
NEK4 NEK4 84.0 100
NEK5 NEK5 100.0 100
NEK6 NEK6 89.7 100
NEK7 NEK7 75.7 100
NEK9 NEK9 80.3 100
MAP3K14 NIK 100.0 100
NIM1K NIM1 100.0 100
NLK NLK 100.0 100
OXSR1 OSR1 69.9 100
MAPK14 p38-alpha 97.0 100
MAPK11 p38-beta 98.7 100
MAPK13 p38-delta 100.0 100
MAPK12 p38-gamma 98.8 100
PAK1 PAK1 94.5 100
PAK2 PAK2 89.5 100
PAK3 PAK3 76.3 100
PAK4 PAK4 100.0 100
PAK6 PAK6 70.5 100
PAK5 PAK7 96.0 100
CDK16 PCTK1 93.0 100
CDK17 PCTK2 100.0 100
CDK18 PCTK3 100.0 100
PDGFRA PDGFRA 92.6 100
PDGFRB PDGFRB 100.0 100
PDPK1 PDPK1 95.5 100
CDPK1 PFCDPK1(P.falciparum) 90.1 100
PK5 PFPK5(P.falciparum) 33.0 100
CDK15 PFTAIRE2 89.7 100
CDK14 PFTK1 100.0 100
PHKG1 PHKG1 100.0 100
PHKG2 PHKG2 100.0 100
PIK3C2B PIK3C2B 69.2 100
PIK3C2G PIK3C2G 59.6 100
PIK3CA PIK3CA(Q546K) 100.0 100
PIK3CB PIK3CB 77.1 100
PIK3CD PIK3CD 98.8 100
PIK3CG PIK3CG 85.4 100
PI4KB PIK4CB 81.2 100
PIKFYVE PIKFYVE 89.4 100
PIM1 PIM1 100.0 100
PIM2 PIM2 87.9 100
PIM3 PIM3 89.2 100
PIP5K1A PIP5K1A 93.0 100
PIP5K1C PIP5K1C 100.0 100
PIP4K2B PIP5K2B 61.3 100
PIP4K2C PIP5K2C 97.5 100
PRKACA PKAC-alpha 100.0 100
PRKACB PKAC-beta 71.5 100
PKMYT1 PKMYT1 93.1 100
PKN1 PKN1 100.0 100
PKN2 PKN2 96.3 100
PKNB PKNB(M.tuberculosis) 86.7 100
PLK1 PLK1 20.2 100
PLK2 PLK2 100.0 100
PLK3 PLK3 100.0 100
PLK4 PLK4 56.5 100
PRKCD PRKCD 89.0 100
PRKCE PRKCE 100.0 100
PRKCH PRKCH 74.6 100
PRKCI PRKCI 96.2 100
PRKCQ PRKCQ 100.0 100
PRKD1 PRKD1 90.1 100
PRKD2 PRKD2 100.0 100
PRKD3 PRKD3 100.0 100
PRKG1 PRKG1 77.5 100
PRKG2 PRKG2 69.9 100
EIF2AK2 PRKR 75.8 100
PRKX PRKX 97.2 100
PRPF4B PRP4 82.6 100
PTK2B PYK2 72.5 100
SIK3 QSK 100.0 100
RAF1 RAF1 100.0 100
RET RET(V804M) 100.0 100
RIOK1 RIOK1 100.0 100
RIOK2 RIOK2 100.0 100
RIOK3 RIOK3 100.0 100
RIPK1 RIPK1 95.9 100
RIPK2 RIPK2 96.8 100
RIPK4 RIPK4 92.8 100
DSTYK RIPK5 100.0 100
ROCK1 ROCK1 100.0 100
ROCK2 ROCK2 85.3 100
ROS1 ROS1 91.5 100
RPS6KA4 RPS6KA4(Kin.Dom.2-C-terminal) 95.1 100
RPS6KA5 RPS6KA5(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA1 RSK1(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA3 RSK2(Kin.Dom.2-C-terminal) 73.8 100
RPS6KA2 RSK3(Kin.Dom.2-C-terminal) 100.0 100
RPS6KA6 RSK4(Kin.Dom.2-C-terminal) 100.0 100
RPS6KB1 S6K1 85.9 100
SBK1 SBK1 51.1 100
SGK1 SGK 64.9 100
SBK3 SgK110 100.0 100
SGK2 SGK2 57.3 100
SGK3 SGK3 100.0 100
SIK1 SIK 100.0 100
SIK2 SIK2 88.9 100
SLK SLK 93.6 100
NUAK2 SNARK 93.1 100
SNRK SNRK 90.1 100
SRC SRC 100.0 100
SRMS SRMS 100.0 100
SRPK1 SRPK1 89.7 100
SRPK2 SRPK2 91.9 100
SRPK3 SRPK3 100.0 100
STK16 STK16 78.0 100
STK33 STK33 100.0 100
STK35 STK35 97.3 100
STK36 STK36 95.5 100
STK39 STK39 100.0 100
SYK SYK 90.0 100
MAP3K7 TAK1 92.6 100
TAOK1 TAOK1 89.5 100
TAOK2 TAOK2 84.7 100
TAOK3 TAOK3 98.6 100
TBK1 TBK1 86.4 100
TEC TEC 91.2 100
TESK1 TESK1 95.2 100
TGFBR1 TGFBR1 83.0 100
TGFBR2 TGFBR2 100.0 100
TIE1 TIE1 86.8 100
TEK TIE2 95.2 100
TLK1 TLK1 100.0 100
TLK2 TLK2 89.9 100
TNIK TNIK 75.8 100
TNK1 TNK1 100.0 100
TNK2 TNK2 100.0 100
TNNI3K TNNI3K 100.0 100
NTRK1 TRKA 64.5 100
NTRK2 TRKB 67.2 100
NTRK3 TRKC 80.0 100
TRPM6 TRPM6 77.1 100
TSSK1B TSSK1B 100.0 100
TSSK3 TSSK3 100.0 100
TTK TTK 78.8 100
TXK TXK 88.4 100
TYK2 TYK2(JH2domain-pseudokinase) 100.0 100
TYRO3 TYRO3 100.0 100
ULK1 ULK1 73.1 100
ULK2 ULK2 76.0 100
ULK3 ULK3 68.1 100
KDR VEGFR2 100.0 100
PIK3C3 VPS34 67.2 100
VRK2 VRK2 100.0 100
WEE1 WEE1 81.4 100
WEE2 WEE2 89.5 100
WNK1 WNK1 100.0 100
WNK2 WNK2 98.6 100
WNK3 WNK3 0.0 100
WNK4 WNK4 31.8 100
STK32A YANK1 89.7 100
STK32B YANK2 63.9 100
STK32C YANK3 100.0 100
YES1 YES 100.0 100
STK25 YSK1 72.5 100
MAP3K19 YSK4 100.0 100
MAP3K20 ZAK 96.9 100
ZAP70 ZAP70 88.5 100

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